Abstract: An image processing device (2A) comprises: an input means for inputting a brightfield image representing cell morphology in a tissue section, and a fluorescence image representing, by fluorescent bright spots, the expression of a specific protein in the same range of the tissue section; a first generation means for generating a cell image obtained by extracting a specific site of a cell from the brightfield image; a second generation means for generating an image obtained by extracting bright spot regions from the fluorescence image, creating a brightness profile for each bright spot region, and generating a fluorescent particle image obtained by extracting the fluorescent particles in the bright spot regions on the basis of the fluorescence profile for one fluorescent particle, which serves as a fluorescence bright spot source; and a calculation means for superimposing the cell image and the fluorescent particle image on one another.

Abstract: An image processing apparatus contains an input unit to input a fluorescent image and a morphological image of a tissue. A biological substance expressed at a first structure of a cell in the tissue is stained by a fluorescent substance. The fluorescent image illustrates a fluorescent bright point which represents expression of the biological substance. The morphological image illustrates a morphology of a second structure of a cell in the tissue and contains the same range of the tissue as the fluorescent image. The apparatus further contains a feature amount extraction unit to extract a feature amount of the second structure from the morphological image, a bright point extraction unit to extract the fluorescent bright point from the fluorescent image, and a region of interest determination unit to determine a region of interest based on the feature amount of the second structure and a distribution of the fluorescent bright point.

Abstract: An image processing device (2A) comprises: an input means for inputting a brightfield image representing cell morphology in a tissue section, and a fluorescence image representing, by fluorescent bright spots, the expression of a specific protein in the same range of the tissue section; a first generation means for generating a cell image obtained by extracting a specific site of a cell from the brightfield image; a second generation means for generating an image obtained by extracting bright spot regions from the fluorescence image, creating a brightness profile for each bright spot region, and generating a fluorescent particle image obtained by extracting the fluorescent particles in the bright spot regions on the basis of the fluorescence profile for one fluorescent particle, which serves as a fluorescence bright spot source; and a calculation means for superimposing the cell image and the fluorescent particle image on one another.

Abstract: An image processing device (2A) comprises: an input means for inputting a brightfield image representing cell morphology in a tissue section, and a fluorescence image representing, by fluorescent bright spots, the expression of a specific protein in the same range of the tissue section; a first generation means for generating a cell image obtained by extracting a specific site of a cell from the brightfield image; a second generation means for generating an image obtained by extracting bright spot regions from the fluorescence image, creating a brightness profile for each bright spot region, and generating a fluorescent particle image obtained by extracting the fluorescent particles in the bright spot regions on the basis of the fluorescence profile for one fluorescent particle, which serves as a fluorescence bright spot source; and a calculation means for superimposing the cell image and the fluorescent particle image on one another.

Abstract: An image processing device prepares an interest image from an image obtained by photographing a cell in a sample and includes a cell image inputting unit, a setting unit, a preparation unit, and a display. The image is input to the image inputting unit. The setting unit sets one or more target images in the image. The preparation unit prepares plural candidate images by performing image processing of each of the one or more target images using one or more prescribed parameters. The display displays the plural candidate images prepared by the preparation unit.

Abstract: An image processing device (2A) comprises: an input means for inputting a brightfield image representing cell morphology in a tissue section, and a fluorescence image representing, by fluorescent bright spots, the expression of a specific protein in the same range of the tissue section; a first generation means for generating a cell image obtained by extracting a specific site of a cell from the brightfield image; a second generation means for generating an image obtained by extracting bright spot regions from the fluorescence image, creating a brightness profile for each bright spot region, and generating a fluorescent particle image obtained by extracting the fluorescent particles in the bright spot regions on the basis of the fluorescence profile for one fluorescent particle, which serves as a fluorescence bright spot source; and a calculation means for superimposing the cell image and the fluorescent particle image on one another.

Abstract: An image processing device (2A) comprises: an input means for inputting a brightfield image representing cell morphology in a tissue section, and a fluorescence image representing, by fluorescent bright spots, the expression of a specific protein in the same range of the tissue section; a first generation means for generating a cell image obtained by extracting a specific site of a cell from the brightfield image; a second generation means for generating an image obtained by extracting bright spot regions from the fluorescence image, creating a brightness profile for each bright spot region, and generating a fluorescent particle image obtained by extracting the fluorescent particles in the bright spot regions on the basis of the fluorescence profile for one fluorescent particle, which serves as a fluorescence bright spot source; and a calculation means for superimposing the cell image and the fluorescent particle image on one another.

Abstract: An image processing device (2A) comprises: an input means for inputting a brightfield image representing cell morphology in a tissue section, and a fluorescence image representing, by fluorescent bright spots, the expression of a specific protein in the same range of the tissue section; a first generation means for generating a cell image obtained by extracting a specific site of a cell from the brightfield image; a second generation means for generating an image obtained by extracting bright spot regions from the fluorescence image, creating a brightness profile for each bright spot region, and generating a fluorescent particle image obtained by extracting the fluorescent particles in the bright spot regions on the basis of the fluorescence profile for one fluorescent particle, which serves as a fluorescence bright spot source; and a calculation means for superimposing the cell image and the fluorescent particle image on one another.

Abstract: An image processing device prepares an interest image from an image obtained by photographing a cell in a sample and includes a cell image inputting unit, a setting unit, a preparation unit, and a display. The image is input to the image inputting unit. The setting unit sets one or more target images in the image. The preparation unit prepares plural candidate images by performing image processing of each of the one or more target images using one or more prescribed parameters. The display displays the plural candidate images prepared by the preparation unit.

Abstract: An image processing apparatus contains an input unit to input a fluorescent image and a morphological image of a tissue. A biological substance expressed at a first structure of a cell in the tissue is stained by a fluorescent substance. The fluorescent image illustrates a fluorescent bright point which represents expression of the biological substance. The morphological image illustrates a morphology of a second structure of a cell in the tissue and contains the same range of the tissue as the fluorescent image. The apparatus further contains a feature amount extraction unit to extract a feature amount of the second structure from the morphological image, a bright point extraction unit to extract the fluorescent bright point from the fluorescent image, and a region of interest determination unit to determine a region of interest based on the feature amount of the second structure and a distribution of the fluorescent bright point.

Abstract: An image processing device inputs a bright field linage of a tissue slice in which a cell nucleus is stained and a fluorescent image of the tissue slice in which a specific biological substance is stained with a fluorescent staining reagent (S10), extracts a cell nucleus from the image of the cell nucleus (S20), extracts a fluorescent bright point from the fluorescent image (S30), specifies a cell nucleus to which the fluorescent bright point is assigned on the basis of the distance between the cell nucleus and the fluorescent bright point, and assigns the fluorescent bright point with the cell nucleus (S40).

Abstract: An image processing device inputs a bright field linage of a tissue slice in which a cell nucleus is stained and a fluorescent image of the tissue slice in which a specific biological substance is stained with a fluorescent staining reagent (S10), extracts a cell nucleus from the image of the cell nucleus (S20), extracts a fluorescent bright point from the fluorescent image (S30), specifies a cell nucleus to which the fluorescent bright point is assigned on the basis of the distance between the cell nucleus and the fluorescent bright point, and assigns the fluorescent bright point with the cell nucleus (S40).

Abstract: An image input device capable of obtaining a luminance signal and a chromaticity signal appropriately even when photographing at nighttime is provided. Further, an image processing device capable of forming an image in which an object can be confirmed visually even under a low luminance environment is provided. Since a color space converting unit assigns weights to the visible light component and the infrared light component based on positional information acquired by the positional information acquiring unit, and converts the original image data into color space including the luminance signal and the chromaticity signal, it is possible to obtain the color space appropriately according to a height of the object and a distance to the object.

Abstract: Deformability of blood cells is quantified in a short time. A blood fluidity measurement apparatus is provided with a TV camera which photographs a stream of blood in either two areas of the internal area, entrance area, and exit area of a gate, an image processing part which calculates the velocity of the blood cells contained in the blood from the image taken by the TV camera, and a deformability calculation means which calculates the deformability of the blood cells a blood fluidity from the velocity.

Abstract: To quantify the aggregation ability of various types of blood cells respectively within a short period of time. An apparatus for achieving the above-described object, which includes: a TV camera for taking an image of blood flow; an image processing section for identifying the types of blood cells contained in a blood cell retention part, in which blood cells are retained, from a blood flow image taken by the TV camera; and an aggregation ability calculation device for calculating at least one of the area, cell count and position of blood cells of each type as the aggregation ability of blood.

Abstract: An image input device capable of obtaining a luminance signal and a chromaticity signal appropriately even when photographing at nighttime is provided. Further, an image processing device capable of forming an image in which an object can be confirmed visually even under a low luminance environment is provided. Since a color space converting unit assigns weights to the visible light component and the infrared light component based on positional information acquired by the positional information acquiring unit, and converts the original image data into color space including the luminance signal and the chromaticity signal, it is possible to obtain the color space appropriately according to a height of the object and a distance to the object.

Abstract: An image processing method for forming a color conversion table to convert plural input colors into output colors, the method including the steps of: extracting color values of plural gray scales wherein in input and output characteristic data, a signal value of one color is variable and signal values of other colors are fixed; creating a model with which difference values between input and output color values are outputted by inputting the extracted color values; and estimating the output color values corresponding to the input color values to create the color conversion table to convert plural input colors into output colors, after shifting the color values by adding or subtracting the difference values which are obtained by inputting the color values into the model with respect to every output color values.

Abstract: To quantify the aggregation ability of various types of blood cells respectively within a short period of time. An apparatus for achieving the above-described object, which includes: a TV camera for taking an image of blood flow; an image processing section for identifying the types of blood cells contained in a blood cell retention part, in which blood cells are retained, from a blood flow image taken by the TV camera; and an aggregation ability calculation device for calculating at least one of the area, cell count and position of blood cells of each type as the aggregation ability of blood.

Abstract: Blood fluidity is measured in a short time. A blood fluidity measurement system, which measures blood fluidity by flowing blood into a channel, is equipped with a TV camera which photographs the blood stream in the channel and an image processing part which detects the state of the blood stream in the channel as blood fluidity from the image taken by the TV camera.

Abstract: Deformability of blood cells is quantified in a short time. A blood fluidity measurement apparatus is provided with a TV camera which photographs a stream of blood in either two areas of the internal area, entrance area, and exit area of a gate, an image processing part which calculates the velocity of the blood cells contained in the blood from the image taken by the TV camera, and a deformability calculation means which calculates the deformability of the blood cells a blood fluidity from the velocity.