Abstract: A method for producing a protein encoded by a target gene, comprising the step of expressing the target gene in a bacterium of the genus Burkholderia, wherein the bacterium lacks one or more genes selected from the group consisting of BSFP_068740, BSFP_068730, and BSFP_068720, or has inhibited expression of the genes or proteins encoded by the genes.

Abstract: A pillar-shaped honeycomb structure including an outer peripheral side wall, and a plurality of partition walls disposed on an inner peripheral side of the outer peripheral side wall, the plurality of partition walls partitioning a plurality of cells forming flow paths from a first end surface to a second end surface, wherein an average pore diameter of the partition walls measured by a mercury porosimeter is 10 ?m or less, and when a cross section of the plurality of partition walls is observed with an X-ray microscope and porosities (%) of each partition wall is measured in a thickness direction from one surface to the other surface of each partition wall, an average porosity of each partition wall is 40 to 70%, and a difference between a maximum value and a minimum value of the porosity of each partition wall is 11% or less.

Abstract: A pillar-shaped honeycomb structure includes an outer peripheral side wall, and a plurality of partition walls partitioning a plurality of cells, wherein an average pore diameter of the partition walls measured by a mercury intrusion method specified in JIS R1655: 2003 is 3 to 10 ?m, and when a cross-section of the plurality of partition walls is observed with an X-ray microscope and a porosity (%) is measured in a thickness direction from one surface to the other surface of each partition wall, assuming PAVE is an average porosity of each partition wall, P1 MIN is a minimum porosity from the one surface to a thickness of 5% of the partition wall, and P2MIN is a minimum porosity from the other surface to a thickness of 5% of the partition wall, 40% PAVE ?70%, and {(P1 MIN+P2MIN)/2} /PAVE ?0.9 are satisfied.

Abstract: Provided are proteins having NF-?B activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-?B. Using plasmid pNF ?B-Luc, cDNA encoding a protein capable of activating NF-?B has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-?B activation.

Abstract: Provided are proteins having NF-?B activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-?B. Using plasmid pNF?B-Luc, cDNA encoding a protein capable of activating NF-?B has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-?B activation.

Abstract: Provided are proteins having NF-?B activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-?B. Using plasmid pNF?B-Luc, cDNA encoding a protein capable of activating NF-?B has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transforrnant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-?B activation.

Abstract: Provided are proteins having NF-&kgr;B activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-&kgr;B. Using plasmid pNF&kgr;B-Luc, cDNA encoding a protein capable of activating NF-&kgr;B has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-&kgr;B activation.

Abstract: Provided are proteins having NF-&kgr; B activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-&kgr; B. Using plasmid pNF&kgr; B-Luc, cDNA encoding a protein capable of activating NF-&kgr; B has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-&kgr; B activation.

Abstract: Provided are proteins having NF-&kgr;B activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-&kgr;B. Using plasmid pNF&kgr;B-Luc, cDNA encoding a protein capable of activating NF-&kgr;B has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-&kgr;B activation.

Abstract: Provided are proteins having NF-kB activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-kB. Using plasmid pNFkB-Luc, cDNA encoding a protein capable of activating NF-kB has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-kB activation.

Abstract: Proteins having activity that promotes STAT6 activation, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of STAT6 are provided. Using a STAT6 response reporter plasmid, cDNA encoding a protein capable of promoting STAT6 activation was cloned from the cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence are determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting STAT6 activation.