Patents by Inventor Shuji Yonezawa
Shuji Yonezawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10513513Abstract: Crystals of a quinazoline derivative are provided. The present invention relates to an acid addition salt of a compound represented by Formula (I): a pharmaceutical composition containing it, and the like.Type: GrantFiled: May 2, 2019Date of Patent: December 24, 2019Assignee: SHIONOGI & CO., LTD.Inventors: Yukio Tada, Yuusuke Tamura, Shuji Yonezawa
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Publication number: 20190256506Abstract: Crystals of a quinazoline derivative are provided. The present invention relates to an acid addition salt of a compound represented by Formula (I): a pharmaceutical composition containing it, and the like.Type: ApplicationFiled: May 2, 2019Publication date: August 22, 2019Applicant: Shionogi & Co., Ltd.Inventors: Yukio TADA, Yuusuke TAMURA, Shuji YONEZAWA, Kenichi ISHIBASHI, Yuki MURAKAMI
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Patent number: 10329285Abstract: Crystals of a quinazoline derivative are provided. The present invention relates to an acid addition salt of a compound represented by Formula (I): a pharmaceutical composition containing it, and the like.Type: GrantFiled: July 28, 2016Date of Patent: June 25, 2019Assignee: SHIONOGI & CO., LTD.Inventors: Yukio Tada, Yuusuke Tamura, Shuji Yonezawa, Kenichi Ishibashi
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Publication number: 20180215744Abstract: Crystals of a quinazoline derivative are provided. The present invention relates to an acid addition salt of a compound represented by Formula (I): a pharmaceutical composition containing it, and the like.Type: ApplicationFiled: July 28, 2016Publication date: August 2, 2018Applicant: Shionogi & Co., Ltd.Inventors: Yukio TADA, Yuusuke TAMURA, Shuji YONEZAWA, Kenichi ISHIBASHI, Yuki MURAKAMI
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Patent number: 9650371Abstract: The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid ? protein, for example, a compound represented by the formula (I): wherein ring A in an optionally substituted carbocyclic group or an optionally substituted heterocyclic group, R1 is optionally substituted lower alkyl or the like, R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or the like, R3a and R3c are each independently hydrogen, halogen, hydroxy, optionally substituted lower alkyl or the like, or a pharmaceutical acceptable salt thereof, or a solvate thereof.Type: GrantFiled: July 28, 2016Date of Patent: May 16, 2017Assignee: Shionogi & Co., Ltd.Inventors: Akihiro Hori, Shuji Yonezawa, Chiaki Fujikoshi, Sae Matsumoto, Yuuji Kooriyama, Tatsuhiko Ueno, Terukazu Kato
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Publication number: 20160326158Abstract: The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid ? protein, for example., a compound represented by the formula (I): wherein ring A in an optionally substituted carbocyclic group or an optionally substituted heterocyclic group. R1 is optionally substituted lower alkyl or the like, R2a and R2b each independently hydrogen, optionally substituted lower alkyl or the like, R3a and R3c are each independently hydrogen, halogen, hydroxy, optionally substituted lower alkyl or the like, or a pharmaceutical acceptable salt thereof, or a solvate thereof.Type: ApplicationFiled: July 28, 2016Publication date: November 10, 2016Inventors: Akihiro HORI, Shuji YONEZAWA, Chiaki FUJIKOSHI, Sae MATSUMOTO, Yuuji KOORIYAMA, Tatsuhiko UENO, Terukazu KATO
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Publication number: 20160108052Abstract: The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid ? protein, for example, a compound represented by the formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group, R1 is optionally substituted lower alkyl or the like, R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or the like, R3a and R3c are each independently hydrogen, halogen, hydroxy, optionally substituted lower alkyl or the like, or a pharmaceutically acceptable salt thereof, or a solvate thereof.Type: ApplicationFiled: December 28, 2015Publication date: April 21, 2016Inventors: Akihiro Hori, Shuji Yonezawa, Chiaki Fujikoshi, Sae Matsumoto, Yuuji Kooriyama, Tatsuhiko Ueno, Terukazu Kato
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Patent number: 8884062Abstract: This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R3a, R3b, R3c and R3d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid ? protein.Type: GrantFiled: May 6, 2013Date of Patent: November 11, 2014Assignee: Shionogi & Co., Ltd.Inventors: Yuusuke Tamura, Shinji Suzuki, Yukio Tada, Shuji Yonezawa, Chiaki Fujikoshi, Sae Matsumoto, Yuuji Kooriyama, Tatsuhiko Ueno
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Patent number: 8703785Abstract: The present invention provides a compound which has an effect of inhibiting amyloid-? production and is useful as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-? proteins. The present invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein A is optionally substituted carbocyclic diyl or optionally substituted heterocyclic diyl; B is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is a group such as optionally substituted lower alkyl; R2 is a group such as hydrogen; and R3a and R3b are each independently a group such as hydrogen, provided that the following compound is excluded.Type: GrantFiled: October 22, 2009Date of Patent: April 22, 2014Assignee: Shionogi & Co., Ltd.Inventors: Shuji Yonezawa, Yuuji Kooriyama, Gaku Sakaguchi
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Publication number: 20140073815Abstract: This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R3a, R3b, R3c and R3d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid ? protein.Type: ApplicationFiled: May 6, 2013Publication date: March 13, 2014Applicant: SHIONOGI & CO., LTD.Inventors: Yuusuki TAMURA, Shinji SUZUKI, Yukio TADA, Shuji YONEZAWA, Chiaki FUJIKOSHI, Sae MATSUMOTO, Yuuji KOORIYAMA, Tatsuhiko UENO
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Patent number: 8658657Abstract: The present invention provides a compound which has an effect of inhibiting amyloid-? production and is useful as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-? proteins. The present invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein A is optionally substituted carbocyclic diyl or optionally substituted heterocyclic diyl; B is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is a group such as optionally substituted lower alkyl; R2 is a group such as hydrogen; and R3a and R3b are each independently a group such as hydrogen, provided that the following compound is excluded.Type: GrantFiled: October 22, 2009Date of Patent: February 25, 2014Assignee: Shionogi & Co., Ltd.Inventors: Shuji Yonezawa, Yuuji Kooriyama, Gaku Sakaguchi
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Publication number: 20140012013Abstract: Disclosed is a process for producing a pyrazole carboxylic acid derivative which is useful as a significant intermediate of an 11?HSD-1 inhibitor. A compound represented by the Formula (XI): is useful as a significant intermediate of an 11?HSD-1 inhibitor, wherein R1 and R2 are each independently hydrogen or substituted or unsubstituted alkyl, R3 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl and R4 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl.Type: ApplicationFiled: March 15, 2012Publication date: January 9, 2014Applicant: SHIONOGI & CO., LTD.Inventors: Masaaki Uenaka, Shuji Yonezawa, Akira Iida, Mutsumi Takaki, Tomoyuki Ogawa, Satoshi Goda, Yoshikatsu Hirose, Tomohiro Fukuda
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Publication number: 20120172355Abstract: This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R3a, R3b, R3c and R3d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid ? protein.Type: ApplicationFiled: March 12, 2012Publication date: July 5, 2012Applicant: SHIONOGI & CO., LTD.Inventors: Yuusuke TAMURA, Shinji SUZUKI, Yukio TADA, Shuji YONEZAWA, Chiaki FUJIKOSHI, Sae MATSUMOTO, Yuuji KOORIYAMA, Tatsuhiko UENO
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Patent number: 8168630Abstract: This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R3a, R3b, R3c and R3d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid ? protein.Type: GrantFiled: April 23, 2008Date of Patent: May 1, 2012Assignee: Shionogi & Co., Ltd.Inventors: Yuusuke Tamura, Shinji Suzuki, Yukio Tada, Shuji Yonezawa, Chiaki Fujikoshi, Sae Matsumoto, Yuuji Kooriyama, Tatsuhiko Ueno
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Publication number: 20110237576Abstract: The present invention provides a compound which has an effect of inhibiting amyloid-? production and is useful as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-? proteins. The present invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein A is optionally substituted carbocyclic diyl or optionally substituted heterocyclic diyl; B is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is a group such as optionally substituted lower alkyl; R2 is a group such as hydrogen; and R3a and R3b are each independently a group such as hydrogen, provided that the following compound is excluded.Type: ApplicationFiled: October 22, 2009Publication date: September 29, 2011Applicant: SHIONOGI & CO., LTD.Inventors: Shuji Yonezawa, Yuusuke Tamura, Yuuji Kooriyama, Gaku Sakaguchi
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Publication number: 20110190279Abstract: The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid ? protein, for example, a compound represented by the formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group, R1 is optionally substituted lower alkyl or the like, R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or the like, R3a and R3c are each independently hydrogen, halogen, hydroxy, optionally substituted lower alkyl or the like, or a pharmaceutically acceptable salt thereof, or a solvate thereof.Type: ApplicationFiled: June 11, 2009Publication date: August 4, 2011Applicant: SHIONOGI & CO., LTD.Inventors: Akihiro Hori, Shuji Yonezawa, Chiaki Fujikoshi, Sae Matsumoto, Yuuji Kooriyama, Tatsuhiko Ueno, Terukazu Kato
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Publication number: 20100075957Abstract: This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R3 a, R3 b, R3 c and R3 d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid ? protein.Type: ApplicationFiled: April 23, 2008Publication date: March 25, 2010Applicant: SHIONOGI & CO., LTD.Inventors: Yuusuke Tamura, Shinji Suzuki, Yukio Tada, Shuji Yonezawa, Chiaki Fujikoshi, Sae Matsumoto, Yuuji Kooriyama, Tatsuhiko Ueno