Patents by Inventor Shujie Hou

Shujie Hou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRIPTOLIDE CONJUGATES AND USES THEREOF
    Publication number: 20230303618
    Abstract: This disclosure provides triptolide-conjugates, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, as well methods of using such compounds in the treatment of conditions/diseases, such as those relating to cancer, immunomodulation and/or inflammation.
    Type: Application
    Filed: August 20, 2021
    Publication date: September 28, 2023
    Applicants: Reyoung Corporation, Reyoung Drug Discovery Co., LTD.
    Inventors: Frank Shujie HOU, Jian XUE, Yushan ZHAO, Dezu MIAO
  • Small molecule androgen receptor inhibitors and methods of use thereof
    Patent number: 11104646
    Abstract: Small molecule carbazole compounds for use as androgen receptor inhibitors are provided herein. Also provided herein are methods for using the carbazole compounds in treating prostate cancer, including castration-resistant prostate cancer and enzalutamide-resistant prostate cancer. The methods include administering to a subject an effective amount of a compound or composition as described herein.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: August 31, 2021
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Milton L. Brown, Shujie Hou, Partha Banerjee, Karishma Amin
  • Synthesis of mahanine and related compounds
    Patent number: 11053255
    Abstract: Disclosed herein are methods of synthesizing mahanine and related compounds. The synthesis features an intramolecular aryl-alkyne isomerization, transition metal catalyzed cross-coupling and intramolecular carbazole forming reaction.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: July 6, 2021
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Milton L. Brown, Shujie Hou
  • SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20200247751
    Abstract: Small molecule carbazole compounds for use as androgen receptor inhibitors are provided herein. Also provided herein are methods for using the carbazole compounds in treating prostate cancer, including castration-resistant prostate cancer and enzalutamide-resistant prostate cancer. The methods include administering to a subject an effective amount of a compound or composition as described herein.
    Type: Application
    Filed: October 23, 2019
    Publication date: August 6, 2020
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Milton L. Brown, Shujie Hou, Partha Banerjee, Karishma Amin
  • COMPOSITIONS OF SCHISANDRA EXTRACTS AND METHODS THEREOF
    Publication number: 20200188466
    Abstract: This disclosure is directed to compositions comprising the Schisandra Sphenanthera extract and a plant-based compound that comprises one or more of triptolide, colchicine, wilforlide A, celastrol, and their analogs or derivatives. Further disclosed herein are methods of increasing the bioavailability of these plant-based compounds and methods of treating diseases with the compositions.
    Type: Application
    Filed: April 4, 2018
    Publication date: June 18, 2020
    Applicant: Reyoung Corporation
    Inventors: Yushan ZHAO, Dezu MIAO, Shujie HOU, Jingshan HUANG
  • Small molecule androgen receptor inhibitors and methods of use thereof
    Patent number: 10487056
    Abstract: Small molecule carbazole compounds for use as androgen receptor inhibitors are provided herein. Also provided herein are methods for using the carbazole compounds in treating prostate cancer, including castration-resistant prostate cancer and enzalutamide-resistant prostate cancer. The methods include administering to a subject an effective amount of a compound or composition as described herein.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: November 26, 2019
    Assignee: Georgetown University
    Inventors: Milton L. Brown, Shujie Hou, Partha Banerjee, Karishma Amin
  • SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20190077755
    Abstract: Small molecule carbazole compounds for use as androgen receptor inhibitors are provided herein. Also provided herein are methods for using the carbazole compounds in treating prostate cancer, including castration-resistant prostate cancer and enzalutamide-resistant prostate cancer. The methods include administering to a subject an effective amount of a compound or composition as described herein.
    Type: Application
    Filed: November 7, 2018
    Publication date: March 14, 2019
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Milton L. Brown, Shujie Hou, Partha Banerjee, Karishma Amin
  • Small molecule androgen receptor inhibitors and methods of use thereof
    Patent number: 10173978
    Abstract: Small molecule carbazole compounds for use as androgen receptor inhibitors are provided herein. Also provided herein are methods for using the carbazole compounds in treating prostate cancer, including castration-resistant prostate cancer and enzalutamide-resistant prostate cancer. The methods include administering to a subject an effective amount of a compound or composition as described herein.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: January 8, 2019
    Assignee: Georgetown University
    Inventors: Milton L. Brown, Shujie Hou, Partha Banerjee, Karishma Amin
  • SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20180215712
    Abstract: Small molecule carbazole compounds for use as androgen receptor inhibitors are provided herein. Also provided herein are methods for using the carbazole compounds in treating prostate cancer, including castration-resistant prostate cancer and enzalutamide-resistant prostate cancer. The methods include administering to a subject an effective amount of a compound or composition as described herein.
    Type: Application
    Filed: August 2, 2016
    Publication date: August 2, 2018
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Milton L. Brown, Shujie Hou, Partha Banerjee, Karishma Amin
  • Glutathione-cleavable prodrug and methods of use thereof
    Patent number: 10023551
    Abstract: A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: July 17, 2018
    Assignee: Georgetown University
    Inventors: Milton L. Brown, Yali Kong, Jacqueline Smith, Kan Wang, Shujie Hou
  • GLUTATHIONE-CLEAVABLE PRODRUG AND METHODS OF USE THEREOF
    Publication number: 20180105505
    Abstract: A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.
    Type: Application
    Filed: May 12, 2016
    Publication date: April 19, 2018
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Milton L. Brown, Yali Kong, Jacqueline Smith, Kan Wang, Shujie Hou
  • SYNTHESIS OF MAHANINE AND RELATED COMPOUNDS
    Publication number: 20160368927
    Abstract: Disclosed herein are methods of synthesizing mahanine and related compounds. The synthesis features an intramolecular aryl-alkyne isomerization, transition metal catalyzed cross-coupling and intramolecular carbazole forming reaction.
    Type: Application
    Filed: June 22, 2016
    Publication date: December 22, 2016
    Inventors: Milton L. Brown, Shujie Hou