Patents by Inventor Shujie Song

Shujie Song has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for improving heterologous synthesis of into polyketides and use of same
    Patent number: 10920229
    Abstract: The present invention relates to a method for improving the heterologous synthesis of a polyketide by E. coli and use thereof. The yield of the polyketide heterologously synthesized by E. coli is significantly increased by attenuating the expression of seventy-two genes, such as sucC and talB, in a host strain, wherein the highest yield increase rate can reach 60% or more. Currently, erythromycin is the most clear model compound in the study on the biosynthesis of polyketids. The production strain of the present invention enables massive accumulation of 6-deoxyerythronolide (6-dEB), an erythromycin precursor, in the fermentation process, laying the foundation for the industrial production of the heterologous synthesis of erythromycin by E. coli.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: February 16, 2021
    Assignee: CAS Center for Excellence in Molecular Plant Sciences
    Inventors: Yong Wang, Zhiqiang Xiong, Shujie Song, Qiaoxia Liu, Jianfeng Wang
  • METHOD FOR IMPROVING HETEROLOGOUS SYNTHESIS OF ESCHERICHIA COLI INTO POLYKETIDES AND USE OF SAME
    Publication number: 20180016585
    Abstract: The present invention relates to a method for improving the heterologous synthesis of a polyketide by E. coli and use thereof. The yield of the polyketide heterologously synthesized by E. coli is significantly increased by attenuating the expression of seventy-two genes, such as sucC and talB, in a host strain, wherein the highest yield increase rate can reach 60% or more. Currently, erythromycin is the most clear model compound in the study on the biosynthesis of polyketids. The production strain of the present invention enables massive accumulation of 6-deoxyerythronolide (6-dEB), an erythromycin precursor, in the fermentation process, laying the foundation for the industrial production of the heterologous synthesis of erythromycin by E. coli.
    Type: Application
    Filed: May 18, 2015
    Publication date: January 18, 2018
    Applicant: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
    Inventors: Yong Wang, Zhiqiang Xiong, Shujie Song, Qiaoxia Liu, Jianfeng Wang