Abstract: A system (10) for treating tissue within a body is configured to deliver a first level of ultrasound energy to a target tissue region (42) for a first duration resulting in the generation of micro-bubbles (56) in the target tissue region, determine one or more characteristics of the target tissue region in the presence of the micro-bubbles, and deliver a second level of ultrasound energy to the target tissue region for a second duration, wherein one or both of the second energy level and the second duration are based, at least in part, on the determined one or more characteristics of the target tissue region.

Abstract: MRI interference with a co-existing treatment system may be reduced or avoided by carrying out RF-sensitive operations of the treatment system only when gradient field activity of the MRI system is suppressed.

Abstract: Various approaches for heating a target region substantially uniformly include identifying one or more locations of one or more hot spots in the target region and/or surrounding regions of the target region during an ultrasound sonication process; computing a temporal variation to an output parameter of at least one of the transducer elements based at least in part on the identified location(s) of the hot spot(s); and operating the at least one transducer element to achieve the temporal variation of the output parameter so as to minimize the hot spot(s).

Abstract: Disclosed are thermal treatment methods that involve monitoring and/or actively adjusting the temperature of targeted and/or non-targeted tissues.

Abstract: Various approaches for reducing microbubble interference with ultrasound waves transmitted from multiple transducer elements and traversing tissue onto a target region include measuring microbubbles in high-throughput areas of ultrasound exposure and reducing the amount of microbubbles using the ultrasound waves.

Abstract: Disclosed are systems and methods for focusing ultrasound transducers that include multiple separate, independently movable transducer segments.

Abstract: A magnetic-resonance-guided focused ultrasound system may be calibrated by generating ultrasound foci using ultrasound transducers, establishing coordinates of the foci and of magnetic-resonance trackers associated with the transducers, and determining a geometric relationship between the trackers and the transducers.

Abstract: Skull inhomogeneity may be quantified in accordance with the skull density measured in skull images acquired using a conventional imager; the quantified inhomogeneity may then be used to determine whether the patient is suitable for ultrasound treatment and/or determine parameters associated with the ultrasound transducer for optimizing transskull ultrasound treatment.

Abstract: Techniques for temperature measurement and correction in long-term MR thermometry utilize a known temperature distribution in an MR imaging area as a baseline for absolute temperature measurement. Phase shifts that arise from magnetic field drifts are detected in one or more portions of the MR imaging area, facilitating correction of temperature measurements in an area of interest.

Abstract: In ultrasound therapy, the frequency of sonications can be optimized, within a certain frequency range, to maximize the absorption or the acoustic intensity at the target in a manner specific to the patient.

Abstract: An asymmetric ultrasound transducer array may include multiple regions or groups of transducer elements. The regions may be configured to generate respective ultrasound beams with different capabilities, such as, e.g., focusing at varying focal depths and lateral steering, and/or focusing into different volumes.

Abstract: Ultrasound focusing may be improved by combining knowledge of the target tissue and/or focusing arrangement with focus measurements.

Abstract: Systems and methods for focusing ultrasound through the skull into the brain for diagnostic or therapeutic purposes may be improved by utilizing both longitudinal and shear waves. The relative contribution of the two modes may be determined based on the angle of incidence.

Abstract: A method for transcostal ultrasound treatment of tissues includes determining rib locations, e.g., based on ultrasound reflections off the ribs or acoustic radiation force signals, and transcostally focusing ultrasound into the tissue while minimizing damage to the ribs.

Abstract: A method for spatially localizing a rib cage prior to transcostal ultrasound treatment of visceral tissue includes computationally refining a three-dimensional model of the rib cage based on image slices taken at multiple locations along the ribs with orientations dependent on local rib orientations.

Abstract: A focused ultrasound system includes an ultrasound transducer device forming an opening, and having a plurality of transducer elements positioned at least partially around the opening. A focused ultrasound system includes a structure having a first end for allowing an object to be inserted and a second end for allowing the object to exit, and a plurality of transducer elements coupled to the structure, the transducer elements located relative to each other in a formation that at least partially define an opening, wherein the transducer elements are configured to emit acoustic energy that converges at a focal zone.

Abstract: MRI interference with a co-existing treatment system may be reduced or avoided by carrying out RF-sensitive operations of the treatment system only when gradient field activity of the MRI system is suppressed.

Abstract: A method for treating body tissue using acoustic energy includes identifying a target focal zone of tissue to be treated, delivering a first pulse of acoustic energy from a transducer to generate bubbles in a tissue region located distally, relative to the transducer, of a focal center of the target focal zone, and delivering a second pulse of acoustic energy from the transducer in the presence of the bubbles generated by the first pulse, the second pulse focused at the focal center to generate thermal ablation energy. In a further embodiment, a method of treating body tissue using ultrasound energy includes identifying a target focal zone to be treated and delivering a plurality of pulses of acoustic ablation energy to locations distributed symmetrically in or proximate a focal plane about the focal center of the target focal zone.

Abstract: Systems and methods for heating a surface substantially uniformly are provided. In various embodiments, the uniform heating is achieved by moving an ultrasound beam across the surface and/or by sequentially irradiating individual meshes of a mesh grid defined over the surface.

Abstract: A thermal treatment system including a heat applying element for generating thermal doses for ablating a target mass in a patient, a controller for controlling thermal dose properties of the heat applying element, an imager for providing preliminary images of the target mass and thermal images during the treatment, and a planner for automatically constructing a treatment plan, comprising a series of treatment sites that are each represented by a set of thermal dose properties. The planner automatically constructs the treatment plan based on input information including one or more of a volume of the target mass, a distance from a skin surface of the patient to the target mass, a set of default thermal dose prediction properties, a set of user specified thermal dose prediction properties, physical properties of the heat applying elements, and images provided by the imager.