Patents by Inventor Shulamit Michaeli

Shulamit Michaeli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MAGNETIC INORGANIC IRON-BASED NANOPARTICLES
    Publication number: 20230287421
    Abstract: A nanoparticle, which has a metal oxide core and a cerium shell is provided. The weight ratio of the cerium within the shell to the metal oxide in the core is at least 1%. Additionally a method for delivering a ligand into a cell with the nanoparticle is provided. Processes for making the nanoparticle which include: sonicating an aqueous composition containing Ceric Ammonium Nitrate and a prefabricated nano particle suspension; and (b) adding a polycationic polymer to the mixture (for NP surface functionalization), are also described.
    Type: Application
    Filed: December 29, 2022
    Publication date: September 14, 2023
    Inventors: Jean-Paul LELLOUCHE, Shulamit MICHAELI, Limor Liron ISRAEL, Emmanuel LELLOUCHE, Yekaterina KAPILOV-BUCHMAN
  • MAGNETIC INORGANIC IRON-BASED NANOPARTICLES
    Publication number: 20160281082
    Abstract: A nanoparticle, which has a metal oxide core and a cerium shell is provided. The weight ratio of the cerium within the shell to the metal oxide in the core is at least 1%. Additionally a method for delivering a ligand into a cell with the nanoparticle is provided.
    Type: Application
    Filed: January 19, 2014
    Publication date: September 29, 2016
    Applicant: Bar Ilan University
    Inventors: Jean-Paul Lellouche, Shulamit Michaeli, Limor Liron, Emmanuel Lellouche, Yekaterina Kapilov-Buchman
  • Plants resistant to cytoplasm-feeding parasites
    Patent number: 8716554
    Abstract: The present invention relates to transgenic plants resistant to parasites that their normal life cycle includes feeding on the plant cytoplasm, including insects, nematodes and fungi, wherein the plants are engineered to produce small interfering RNAs (siRNAs) capable of silencing a parasite specific gene. Particularly the parasite gene is a stage-specific gene, more particularly a gene involved in essential, early developmental stages of the parasite in or on the plant.
    Type: Grant
    Filed: August 22, 2004
    Date of Patent: May 6, 2014
    Assignee: Rahan Meristem (1998) Ltd. Plant Propagation & Biotechnology
    Inventors: Shulamit Michaeli, David Kenigsbuch, Orna Livneh, David Levy, Eli Khayat
  • SnoRNAi-small nucleolar RNA degradation by RNA interference in trypanosomatids
    Patent number: 8486910
    Abstract: Polynucleotides and a method suitable for downregulation of small nuclear RNA which can be used to treat diseases associated with activity of small nuclear RNA are provided. Specifically, the present invention can be used to downregulate snoRNA molecules or box H/ACA-containing RNA molecules which are involved in diseases such as cancer.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: July 16, 2013
    Assignee: Bar-Ilan University
    Inventor: Shulamit Michaeli
  • Snornai-small nucleolar RNA degradation by RNA interference in trypanosomatids
    Patent number: 8338583
    Abstract: Polynucleotides and a method suitable for downregulation of small nuclear RNA which can be used to treat diseases associated with activity of small nuclear RNA are provided. Specifically, the present invention can be used to downregulate snoRNA molecules or box H/ACA-containing RNA molecules which are involved in diseases such as cancer.
    Type: Grant
    Filed: February 4, 2004
    Date of Patent: December 25, 2012
    Assignee: Bar-Ilan University
    Inventor: Shulamit Michaeli
  • SNORNAI-SMALL NUCLEOLAR RNA DEGRADATION BY RNA INTERFERENCE IN TRYPANOSOMATIDS
    Publication number: 20120165399
    Abstract: Polynucleotides and a method suitable for downregulation of small nuclear RNA which can be used to treat diseases associated with activity of small nuclear RNA are provided. Specifically, the present invention can be used to downregulate snoRNA molecules or box H/ACA-containing RNA molecules which are involved in diseases such as cancer.
    Type: Application
    Filed: March 12, 2012
    Publication date: June 28, 2012
    Applicant: Bar-Ilan University
    Inventor: Shulamit MICHAELI
  • Plants resistant to cytoplasm-feeding parasites
    Publication number: 20070199100
    Abstract: The present invention relates to transgenic plants resistant to parasites that their normal life cycle includes feeding on the plant cytoplasm, including insects, nematodes and fungi, wherein the plants are engineered to produce small interfering RNAs (siRNAs) capable of silencing a parasite specific gene. Particularly the parasite gene is a stage-specific gene, more particularly a gene involved in essential, early developmental stages of the parasite in or on the plant.
    Type: Application
    Filed: August 22, 2004
    Publication date: August 23, 2007
    Inventors: Shulamit Michaeli, David Kenigsbuch, Orna Livneh, David Levy, Eli Khayat
  • Snornai-small nucleolar rna degradation by rna interference in trypanosomatids
    Publication number: 20060079471
    Abstract: Polynucleotides and a method suitable for downregulation of small nuclear RNA which can be used to treat diseases associated with activity of small nuclear RNA are provided. Specifically, the present invention can be used to downregulate snoRNA molecules or box H/ACA-containing RNA molecules which are involved in diseases such as cancer.
    Type: Application
    Filed: August 2, 2005
    Publication date: April 13, 2006
    Inventor: Shulamit Michaeli
  • Oligonucleotides and methods using same for treating cox-ll associated diseases
    Publication number: 20040110698
    Abstract: A small interfering duplex oligonucleotide comprising a 15 to 30 base pair sequence being at least 90 % identical to a contiguous nucleic acid sequence of COX-II, as determined using the GCG BestFit software of the Wisconsin sequence analysis package, utilizing the Smith and Waterman algorithm, where gap weight equals 50, length weight equals 3, average match equals 10 and average mismatch equals −9.
    Type: Application
    Filed: December 10, 2002
    Publication date: June 10, 2004
    Applicants: Kimron Veterinary Institute, Bar-llan University
    Inventors: Mordechai Shemesh, Laurence Shore, Yehuda Stram, Shulamit Michaeli, Haim Breitbart