Abstract: Provided herein are methods, compounds, and compositions for reducing expression of DYRKIB in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate a metabolic disease or disorder in an individual in need.

Abstract: The invention discloses a method for preparing graphene oxide quantum dots in a large scale with cryptocrystalline graphite, comprising the following steps: mixing a certain amount of cryptocrystalline graphite powder, sodium nitrate, and sulfuric acid with ultrasonic treating; stirring the solution for 1-3 hours in ice-water bath; adding a certain amount of potassium permanganate, and mixing while stirring, then increasing temperature; adding deionized water, increasing the temperature and maintain for 1-3 hours, then diluting with water and adding a certain amount of hydrogen peroxide, stirring followed by standing and staying overnight; adding hydrochloric solution; adding water into the solution, implementing centrifugal clean till the pH value equals 7, and implementing centrifugally ultrasonic treatment, thereby obtain the graphene oxide quantum dot.

Abstract: An accidental tumbling monitoring method, system and a terminal are disclosed. When a human wearing intelligent shoes is in an accidental tumbling state, whether or not a first inclination angle of soles of the intelligent shoes is restored to a preset inclination range within a first preset time range is determined. If the human tumbles seriously, positioning information of the human wearing the intelligent shoes is sent to a guardian, whether or not a monitoring platform receives feedback information from the guardian within a second preset time range is determined, if not, the monitoring platform sends first aid information of the human wearing the intelligent shoes to an emergency center, and therefore, the situation that the human wearing the intelligent shoes has an accident due to belated treatment is avoided.

Abstract: The LED pixel includes a driver IC (20) and an LED chip (40); the LED chip (40) is stacked and mounted on a surface of the driver IC (20), and a wire (31) going from the cathode of the LED chip (40) is connected to the driver IC (20). The driver IC (20) is an unpackaged die. An insulation layer is disposed on the surface of the die, and a pad (30) disposed on the insulation layer is connected to a positive electrode. The LED chip (40) is mounted on the pad (30), and the anode of the LED chip (40) is electrically connected with the pad (40). This improves the light transmittance of the LED display product.

Abstract: Technologies for providing predictive thermal management include a compute device. The compute device includes a compute engine and an execution assistant device to assist the compute engine in the execution of a workload.

Abstract: Disclosed herein are antisense compounds and methods for modulating TMPRSS6 and modulating an iron accumulation disease, disorder and/or condition in an individual in need thereof. Iron accumulation diseases in an individual such as hemochromatosis or ?-thalassemia can be ameliorated or prevented with the administration of antisense compounds targeted to TMPRSS6.

Abstract: Disclosed herein are compositions and compounds comprising modified oligonucleotides for modulating TMPRSS6 and modulating an iron accumulation disease, disorder and/or condition in an individual in need thereof. Iron accumulation diseases in an individual such as polycythemia, hemochromatosis or ?-thalassemia can be treated, ameliorated, delayed or prevented with the administration of antisense compounds targeted to TMPRSS6.

Abstract: Provided is a light-emitting diode (LED) module, LED panel and LED screen. The LED module includes a composite layer, at least one LED chipset with an LED chip, at least one driver integrated circuit (IC); the composite layer includes a substrate arranged at the front side; the LED chip and the driver IC are installed at the front side of the composite layer, the cathode of the LED chip is connected to the driver IC by golden wire bonding; blind holes are arranged at the front side of the composite layer, the anode of the LED chip is connected to the positive electrode inside the composite layer through one of the blind holes; the wire coming from the VDD pin of the driver IC is connected to the positive electrode inside the composite layer through at least one of the blind holes; the wire coming from the GND pin of the driver IC is connected to the negative electrode inside the composite layer through one of the blind holes; the at least one driver IC is connected with each other through a signal line.

Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting DNM2 expression, which may be useful for treating, preventing, or ameliorating a disease associated with DNM2.

Abstract: Systems are provided for delivering a suture to close a surgical opening. An elongated deployment member may have at its distal end a retracted counterforce member. The counterforce member may be inserted into the surgical opening and deployed to resist being withdrawn from the opening. A compression member may be slid down the elongated member to compress the tissue to be sutured against the counterforce member. Suture passers loaded with suture ends may be passed through needle tubes within the elongated member to emerge from the elongated member and pierce the tissue to be sutured, then deposit the suture ends with a suture catcher. The suture passers may be withdrawn, leaving the suture ends. The suture catcher may be retracted, retaining the suture ends and the device—elongated member, retracted suture catcher, and retained suture end—may be withdrawn from the surgical opening. The suture may then be completed.

Abstract: Provided herein are methods, compounds, and compositions for reducing expression of transthyretin mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate transthyretin amyloidosis, or a symptom thereof.

Abstract: Systems are provided for delivering a suture to close a surgical opening. An elongated deployment member may have at its distal end a retracted counterforce member. The counterforce member may be inserted into the surgical opening and deployed to resist being withdrawn from the opening. A compression member may be slid down the elongated member to compress the tissue to be sutured against the counterforce member. Suture passers loaded with suture ends may be passed through needle tubes within the elongated member to emerge from the elongated member and pierce the tissue to be sutured, then deposit the suture ends with a suture catcher. The suture passers may be withdrawn, leaving the suture ends. The suture catcher may be retracted, retaining the suture ends and the device—elongated member, retracted suture catcher, and retained suture end—may be withdrawn from the surgical opening. The suture may then be completed.

Abstract: In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell. In certain embodiments, the target nucleic acid is a nucleic acid that encodes cartilage oligomeric matrix protein. In certain embodiments, the target nucleic acid is a nucleic acid expressed in the growth plate, tendon, or cartilage.

Abstract: Provided herein are methods, compounds, and compositions for reducing expression of DYRKIB in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate a metabolic disease or disorder in an individual in need.

Abstract: A method of transmitting and receiving a HE PPDU and perform channel estimation enhancement is proposed. The HE PPDU comprises legacy preamble, HE-STF, HE-LTF, and data. A beam-change indication indicates if the pre-multiplied beamforming Q-matrix is changed from legacy preamble to H-SFT, HE-LTF, and data portion. A value of 1 indicates that Q matrix is changed. A value of 0 indicates that Q matrix is unchanged and receiver should be safe to combine L-LTF and HE-LTF. The beam-change indication can be used to significantly enhance channel estimation at receiver. When there is no beam-change, receiver does not change operation during HE-STF and HE-LTF such that the channel estimations can rely on the combination of L-LTFs, L-SIG, RL-SIG, HE-SIGAs and HE-LTF.

Abstract: Disclosed herein are antisense compounds and methods for modulating TMPRSS6 and modulating an iron accumulation disease, disorder and/or condition in an individual in need thereof. Iron accumulation diseases in an individual such as hemochromatosis or ?-thalassemia can be ameliorated or prevented with the administration of antisense compounds targeted to TMPRSS6.

Abstract: Provided herein are methods, compounds, and compositions for reducing expression of transthyretin mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate transthyretin amyloidosis, or a symptom thereof.

Abstract: A method and a device for transmitting enhanced transmission selection (ETS) standard configuration information. The receiving method includes: receiving LLDP packets, wherein, the LLDP packets are in an ETS recommended TLV format; analyzing a first field in the LLDP packets, and determining whether the value of each byte in the first field is in a preset range or not; analyzing the value of a first segment of bits of each byte in the first field when determining that the value of each byte in the first field is in the preset range, and determining a scheduling algorithm used by internal priorities of a traffic class corresponding to each byte in the first field according to the values of the first segment of bits; and analyzing value of a second segment of bits of each byte in the first field, and determining an additional parameter corresponding to the priority.

Abstract: Systems are methods are provided for heating an endoscope to defog or avoid from fogging of lens. The endoscope heater may have an elongated body that attaches to the shaft of an endoscope with a controller to operate a heating element disposed on the body. The controller may maintain the heating element at a predetermined temperature. In use, the controller may be operated to energize the heating element and warm the endoscope above ambient temperature prior to introduction into the patient's body.