Patents by Inventor Shumeye Mamo

Shumeye Mamo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds to treat Alzheimer's disease
    Patent number: 6992081
    Abstract: The present invention is directed toward substituted hydroxyethylene compounds of formulas (XII) (XIII), and (XIV) useful in treating Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: January 31, 2006
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Roy Hom, Shumeye Mamo, Jay Tung, Andrea Gailunas, Varghese John, Lawrence Fang
  • Human adam-10 inhibitors
    Publication number: 20050227973
    Abstract: The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chorides and ADAM-10 modulators therefrom.
    Type: Application
    Filed: December 13, 2002
    Publication date: October 13, 2005
    Inventors: S. Brown, Lynne Canne-Bannen, Erick Co, Vasu Jammalamadaka, Rickard Khoury, Moon Kim, Donna Le, Amy Tsuhako, Morrison Mac, Shumeye Mamo, John Nuss, Michael Prisbylla, Wei Xu
  • Dipeptide inhibitors of beta-secretase
    Publication number: 20050182138
    Abstract: Dipeptide derived inhibitors of the ?-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A? peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce A? peptide formation and in pharmaceutical compositions.
    Type: Application
    Filed: March 8, 2005
    Publication date: August 18, 2005
    Inventors: Varghese John, Jay Tung, Roy Hom, Ashley Guinn, Lawrence Fang, Andrea Gailunas, Shumeye Mamo
  • Compounds to treat Alzheimer's disease
    Publication number: 20030013881
    Abstract: The present invention is directed toward substituted hydroxyethylene compounds of formulas (XII) (XIII), and (XIV) 1
    Type: Application
    Filed: September 21, 2001
    Publication date: January 16, 2003
    Inventors: Roy Hom, Shumeye Mamo, Jay Tung, Andrea Gailunas, Varghese John, Lawrence Fang
  • Compounds to treat alzheimer's disease
    Publication number: 20020022623
    Abstract: The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) 1
    Type: Application
    Filed: March 23, 2001
    Publication date: February 21, 2002
    Inventors: Roy Hom, Shumeye Mamo, Jay Tung, Andrea Gailunas, Varghese John, Lawrence Y. Fang