Shumeye Mamo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
Abstract: The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chorides and ADAM-10 modulators therefrom.
December 13, 2002
October 13, 2005
S. Brown, Lynne Canne-Bannen, Erick Co, Vasu Jammalamadaka, Rickard Khoury, Moon Kim, Donna Le, Amy Tsuhako, Morrison Mac, Shumeye Mamo, John Nuss, Michael Prisbylla, Wei Xu
Abstract: Dipeptide derived inhibitors of the ?-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A? peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce A? peptide formation and in pharmaceutical compositions.
March 8, 2005
August 18, 2005
Varghese John, Jay Tung, Roy Hom, Ashley Guinn, Lawrence Fang, Andrea Gailunas, Shumeye Mamo