Abstract: The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Abstract: A method and a device for preparing cleaned rock salt are provided in the present disclosure. The method includes examining a plurality of rock salt blocks and positioning a qualified rock salt block; performing a first three-dimensional photographing to determine an area of a contaminant; in response to the area of the contaminant, performing a pre-cleaning process, an enhanced cleaning process, and an ultrasonic cleaning process with movable probes or performing a pre-cleaning process; performing an ultrasonic combined cleaning process; monitoring a turbidity level; in response to the turbidity level being monitored, triggering a monitoring alarm or performing a spray cleaning process, an air knife water removal process, and a hot-air drying process on a corresponding rock salt block; after the drying process, performing a second three-dimensional photographing to determine the area of the contaminant; and storing the corresponding rock salt block or performing an online explosive residue detection.

Abstract: An ultrasonic rock salt continuous cleaning method and an ultrasonic rock salt continuous cleaning device are provided. The ultrasonic rock salt continuous cleaning method comprises, in a loading and pre-examining stage, loading and pre-examining a solid substance, where first sample information of the solid substance is collected; in a pre-cleaning stage, pre-cleaning the solid substance, wherein a cleaning fluid is applied; in an ultrasonic cleaning stage, ultrasonic cleaning the solid substance; in a drying stage, drying the solid substance, where the solid substance is dried in two stages, in a first stage, the solid substance is dried using a high-pressure air, and in a second stage, the solid substance is dried using hot air; and in an unloading and examining stage, unloading and examining the rock salts, where second sample information of the solid substance is collected.

Abstract: The invention provides compounds as CDK small-molecule inhibitors and uses thereof, the compounds can be used for treating inflammation and cell proliferation diseases. The novel compound of the invention is a powerful cyclin-dependent kinase 4 (CDK 4) or cyclin-dependent kinase-6 (CDK 6) inhibitor.

Abstract: The invention provides compounds as CDK small-molecule inhibitors and uses thereof, the compounds can be used for treating inflammation and cell proliferation diseases. The novel compound of the invention is a powerful cyclin-dependent kinase 4 (CDK 4) or cyclin-dependent kinase-6 (CDK 6) inhibitor.

Abstract: A molding device includes a male die, a master die core, a male die core located between the male die and the master die core, and a cutting mechanism received in the male die core. The cutting mechanism includes a cutting seat and a cutter. The cutting seat defines a latch slot. The latch slot includes a narrow portion and a wide portion communicating with the narrow portion. The cutter includes a plate body received in the narrow portion and a latch shaft located on the plate body. The latch shaft is engaged in the wide portion. When a plastic product is formed and a sprue gate is around the mold cavity, the plate body is configured to cut the sprue gate, and the plate body is movable relative to the cutting seat around the latch shaft, to prevent the plate body from sticking.

Abstract: The present invention relates to retinal prostheses, and in particular to the transfer of electrical power and data from outside of the human body to such a prosthesis. The retinal prosthesis comprises: A retinal electrode array implanted in the eye to stimulate the retina. A receiving coil implanted sub-sclerally to inductively receive power or data signals, or both. An electrical connection between the implanted receiving coil and the implanted retinal electrode array. Wherein the receiving coil is flexible and able to conform to scleral curvature, when it is implanted. And wherein power or data signals, or both, received by the receiving coil from a remote transmitting coil are automatically provided to the electrode array. According to a second aspect, the present invention provides a method for implanting a retinal prosthesis. In a further aspect the present invention further provides an ocular implant.

Abstract: A molding device includes a male die, a master die core, a male die core located between the male die and the master die core, and a cutting mechanism received in the male die core. The cutting mechanism includes a cutting seat and a cutter. The cutting seat defines a latch slot. The latch slot includes a narrow portion and a wide portion communicating with the narrow portion. The cutter includes a plate body received in the narrow portion and a latch shaft located on the plate body. The latch shaft is engaged in the wide portion. When a plastic product is formed and a sprue gate is around the mold cavity, the plate body is configured to cut the sprue gate, and the plate body is movable relative to the cutting seat around the latch shaft, to prevent the plate body from sticking.

Abstract: A cutting system includes a dam, a cylinder, a hydraulic controlling module, and a PLC controlling module. The hydraulic controlling module includes a reversing valve connected to the cylinder. The PLC controlling module is connected to the reversing valve and adapted to output a control signal to locate the reversing valve in a first open position or a second open position. When the reversing valve is in the first open position, the reversing valve allows the high pressure oil to flow into the cylinder from the hydraulic controlling module, thereby to causing the piston module to push the dam to cut the gate mark; when the reversing valve is in the second open position, the high pressure oil flows back to the hydraulic controlling module.

Abstract: A pressure controlling system includes a pressurized device, a piston device, and an electromagnetic routing valve. The pressurized device includes a moving cavity, and a receiving cavity adapted to receive liquid. A pipe is connected to the receiving cavity, and the pipe is adapted to connect a hydraulic cylinder plate. A connecting pipe, a noise elimination pipe, a first gas transmitting pipe, and a second gas transmitting pipe are connected to the electromagnetic routing valve. The first gas transmitting pipe and the second gas transmitting pipe are connected to the pressurized device.

Abstract: A plastic injection product manufacturing system includes a forming machine, a PLC module, an oil output module, an oil vat, and a cutter. The forming machine includes a mold cavity for forming a plastic injection product. The mold cavity defines a gate for receiving molten plastic material. The PLC module is connected to the forming machine. The oil output module is connected to the PLC module. The oil vat is connected to the oil output module. The oil vat includes a vat body and a piston slidably mounted in the vat body. The cutter is connected to the piston. The PLC module controls the oil output module to output hydraulic pressure oil, after receiving a control signal from the forming machine, to the vat body of the oil vat to drive the piston to move. The cutter is driven to move to cut off plastic material out of the gate.

Abstract: A method for manufacturing a product is provided. Inject a molten plastic in a cavity via a channel and a gate of a mold. Form a molten plastic product with a configuration of the cavity. Maintain a preset pressure in the cavity to maintain the configuration of the molten plastic product in the cavity. Slide a dam to into a position of the gate and remove the gate marks from the molten plastic products. Cool and harden the molten plastic product to form a solid product. Release the preset pressure. Move the dam away from the cavity. Eject the solid product out of the cavity.

Abstract: The present invention relates to retinal prostheses, and in particular to the transfer of electrical power and data from outside of the human body to such a prosthesis. The retinal prosthesis comprises: A retinal electrode array implanted in the eye to stimulate the retina. A receiving coil implanted sub-sclerally to inductively receive power or data signals, or both. An electrical connection between the implanted receiving coil and the implanted retinal electrode array. Wherein the receiving coil is flexible and able to conform to scleral curvature, when it is implanted. And wherein power or data signals, or both, received by the receiving coil from a remote transmitting coil are automatically provided to the electrode array. According to a second aspect, the present invention provides a method for implanting a retinal prosthesis. In a further aspect the present invention further provides an ocular implant.

Abstract: A circuit includes an OPAMP-less bandgap voltage generating core circuit connected between a regulated voltage and a ground reference to generate an output bandgap voltage. A preregulator circuit generates the regulated voltage from an unregulated supply voltage. The preregulator circuit includes a negative feedback loop operable to stabilize the regulated voltage and a current source operable to source current for the regulated voltage, the current source mirroring a PTAT current of the OPAMP-less bandgap voltage generating core circuit. The core circuit further includes a negative feedback loop and a positive feedback loop, the negative and positive feedback loops functioning to equalize two internal voltages within the core.

Abstract: A circuit includes an OPAMP-less bandgap voltage generating core circuit connected between a regulated voltage and a ground reference to generate an output bandgap voltage. A preregulator circuit generates the regulated voltage from an unregulated supply voltage. The preregulator circuit includes a negative feedback loop operable to stabilize the regulated voltage and a current source operable to source current for the regulated voltage, the current source mirroring a PTAT current of the OPAMP-less bandgap voltage generating core circuit. The core circuit further includes a negative feedback loop and a positive feedback loop, the negative and positive feedback loops functioning to equalize two internal voltages within the core.