Patents by Inventor Shun-ichi Hata
Shun-ichi Hata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4578465Abstract: Phenylpiperazine derivatives of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a straight- or branched-chain saturated or unsaturated alkyl group having 1 to 8 carbon atoms which may be substituted at any position by a hydroxyl group, a carboxyl group, a lower alkoxycarbonyl group or an oxo group; and R.sub.2 is a hydrogen atom, a halogen atom, a lower alkyl group or a sulfamoyl group, and a process for producing the same are disclosed. The derivatives of the formula have alpha blocking and serotonin antagonizing activities and are useful as a drug.Type: GrantFiled: April 30, 1984Date of Patent: March 25, 1986Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroyuki Nagano, Mitiro Takagi, Noboru Kubodera, Isao Matsunaga, Hiroyuki Nabata, Yasuhiro Ohba, Kazushige Sakai, Shun-ichi Hata, Yasumi Uchida
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Patent number: 4560686Abstract: Compounds of the formula ##STR1## (wherein R.sub.1 is a lower alkyl group, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a trifluoromethyl group or a lower alkoxycarbonyl group; two adjacent groups of R.sub.2, R.sub.3 and R.sub.4 may combine to form a methylenedioxy group; n is an integer of 2 to 6) or salts thereof, are disclosed.These compounds are useful as agents for treating circulatory diseases because they have hypotensive action and are capable of increasing the cerebral blood flow, decreasing the heart rate and suppressing ventricular arrhythmia due to myocardial ischemia.Type: GrantFiled: September 14, 1983Date of Patent: December 24, 1985Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroyuki Nagano, Mitiro Takagi, Noboru Kubodera, Isao Matsunaga, Hiroyuki Nabata, Yasuhiro Ohba, Kazushige Sakai, Shun-ichi Hata, Yasumi Uchida
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Patent number: 4507309Abstract: A treating agent whose effective ingredient is an anthranyl derivative of the formula: ##STR1## (wherein R.sub.1 and R.sub.2 may be the same or different and represent a hydrogen atom, a hydroxyl group, a lower alkoxy group, preferably C.sub.1 -C.sub.3 alkoxy group, a lower alkyl group, preferably C.sub.1 -C.sub.3 alkyl group, a nitro group or a halogen atom) is disclosed.Type: GrantFiled: April 12, 1982Date of Patent: March 26, 1985Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Shin-ichi Kaiho, Koji Mizuno, Shun-ichi Hata, Masuo Koizumi, Masamitsu Honda, Yasushi Murakami, Shigeru Takanashi, Minoru Shindo
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Patent number: 4447453Abstract: An anti-peptic ulcer agent which contains as an active ingredient aminobenzoic acid compounds of the formula ##STR1## (wherein R.sub.1, R.sub.2, and R.sub.3 which may be the same or different represent a hydrogen atom, halogen atom, lower alkyl group or lower alkoxy group but they do not represent a hydrogen atom at the same time) or pharmaceutically acceptable salts thereof and a method of preventing or treating a human in need of said prevention or treatment an effective amount of said active ingredient are disclosed.Type: GrantFiled: November 17, 1981Date of Patent: May 8, 1984Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Mitsura Tanemura, Tamotsu Yamazaki, Koji Mizuno, Shin-ichi Kaiho, Morio Kakimoto, Eiichi Hoshino, Isao Matsunaga, Shun-ichi Hata
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Patent number: 4438115Abstract: An agent for treating diseases in circulatory organs which comprises a piperazine compound of the formula ##STR1## wherein R.sub.1, R.sub.2 and A are as defined hereunder, or a salt thereof and a pharmaceutically acceptable carrier.Type: GrantFiled: June 10, 1981Date of Patent: March 20, 1984Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroyuki Nagano, Mitiro Takagi, Noboru Kubodera, Isao Matsunaga, Tamotsu Yamazaki, Hiroyuki Nabata, Kazushige Sakai, Shun-ichi Hata
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Patent number: 4435391Abstract: Dibenzoxazepine derivatives of the formula: ##STR1## wherein R.sub.1, n, R.sub.2 and R.sub.3 are as defined in the description, process for preparing the same, pharmaceutical composition containing the same and method of treating diseases in circulatory organs administering the composition to a patient are disclosed.The compounds of the formula have lipid lowering activity, lipid peroxide lowering activity, blood sugar lowering activity and activity to inhibit the aggregation of platelets, and hence are useful as a medicine.Type: GrantFiled: March 4, 1982Date of Patent: March 6, 1984Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kazuo Sasahara, Masamitsu Honda, Masuo Koizumi, Yasushi Murakami, Tomohiro Neichi, Hiroshi Nakakimura, Yukifumi Noda, Hiroshi Matsushita, Shun-ichi Hata
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Patent number: 4415569Abstract: Pyrazoloindazole derivatives of the formula: ##STR1## [wherein R.sub.1 is a cyano group, carboxy group, a lower alkoxycarbonyl group or a group ##STR2## (wherein R.sub.2 and R.sub.3 are each a hydrogen atom, a lower alkyl group, a phenyl group which may have a substituent or when taken together with a nitrogen atom, form a heterocyclic ring); X.sup..crclbar. is a counter ion], a process for preparing the same and a pharamaceutical composition containing the same are disclosed. The compounds of the formula above have bronchodilating action and are useful as a medicine.Type: GrantFiled: December 17, 1981Date of Patent: November 15, 1983Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Fujimura Yasuo, Tanaka Sadao, Matsunaga Isao, Yasuyuki Shiraki, Yugo Ikeda, Tamotsu Yamazaki, Yasuhiro Ohba, Kazushige Sakai, Shun-ichi Hata, Minoru Shindo
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Patent number: 4409234Abstract: Novel pyrazoloindazole derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxyl group or benzyloxyl group; R.sub.2 is a hydrogen atom, a halogen atom, a lower alkyl group or phenyl group (provided R.sub.1 and R.sub.2 are not hydrogen at the same time); and X.sup..crclbar. is a halide ion, a hydroxide ion, a methanesulfonate ion, a p-toluene sulfonate ion, a sulfate ion, a nitrate ion, a carbonate ion, an acetate ion, a benzoate ion or a salicylate ion, a process for preparing the derivatives, and a pharmaceutical composition containing the same are disclosed. The derivatives have good bronchodilating action for human without exhibiting substantially bad effects on the functioning of heart, and therefore, they are useful as a drug.Type: GrantFiled: June 3, 1982Date of Patent: October 11, 1983Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Yasuo Fujimura, Sadao Tanaka, Isao Matsunaga, Yasuyuki Shiraki, Yugo Ikeda, Tamotsu Yamazaki, Yasuhiro Ohba, Shun-ichi Hata, Minoru Shindo, Kazushige Sakai
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Patent number: 4379150Abstract: Dibenz[b,f][1,4]oxazepine derivatives of the formula ##STR1## (wherein R.sub.1 is a hydrogen atom or a lower alkyl group; R.sub.2 is a branched lower alkyl group; R.sub.3 is a hydrogen atom, a carboxyl group, a carbamoyl group, a lower alkoxycarbonyl group, or a lower alkoxy group; R.sub.4 and R.sub.5 are each a lower alkyl group or may, when taken together with a nitrogen atom, form a heterocyclic ring; and A is a lower alkylene group) or salts thereof, a process for preparing the same and pharmaceutical compositions comprising the same are disclosed. The derivatives of the formula above are effective to prevent and treat circulatory diseases, especially angina pectoris, and therefore, useful as medicines.Type: GrantFiled: December 17, 1981Date of Patent: April 5, 1983Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kiyohiko Ito, Masuo Koizumi, Yasushi Murakami, Michitaka Akima, Jinichiro Aono, Yasuhiro Ohba, Tamotsu Yamazaki, Kazushige Sakai, Shun-ichi Hata, Shigeru Takanashi
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Patent number: 4366161Abstract: Novel compound, 1,2-bis(nicotinamido)propane and its pharmaceutically acceptable salts, a process for preparing the same and a pharmaceutical composition containing the same as an active ingredient are disclosed.The compound acts to prevent or spasmolyse cerebral vasospasms, to prevent cerebral apoplexy and to lower the lipoperoxide level in blood.Type: GrantFiled: November 17, 1980Date of Patent: December 28, 1982Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Takashi Mori, Sakae Takaku, Fumiaki Matsuura, Yasushi Murakami, Yukifumi Noda, Tamotsu Yamazaki, Tomohiro Neichi, Hiroshi Nakakimura, Shigeyuki Kataoka, Takashi Matsuno, Shun-ichi Hata, Shigeru Takanashi
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Patent number: 4361572Abstract: 1,4,5,6-Tetrahydronicotinamide derivative represented by the formula: ##STR1## (wherein R is defined in the specification), a process of preparing the same and pharmaceutical composition containing the same are disclosed.The compound has action for suppressing aggregation of platelets, and antiinflammatory, antipyretic and analgesic actions.Type: GrantFiled: December 21, 1981Date of Patent: November 30, 1982Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Sakae Takaku, Fumiaki Matsuura, Takashi Mori, Yasushi Murakami, Shigeyuki Kataoka, Yasuhisa Takeda, Yasuhiro Yamashita, Yumiko Takeda, Takashi Matsuno, Koji Mizuno, Shinichi Kaiho, Tamotsu Yamazaki, Shun-ichi Hata, Shigeru Takanashi
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Patent number: 4290953Abstract: Dibenz[b,f][1,4]oxazepine derivatives represented by the formula ##STR1## [wherein R.sub.1, n, R.sub.2 and R.sub.3 are as defined in the specification], and a process for preparing the same are disclosed. The object compounds have excellent serum cholesterol lowering activity, serum lipid lowering activity, blood lipid peroxide lowering activity and anti-aggregation of platelet activity, and therefore are useful as a drug.Type: GrantFiled: December 5, 1979Date of Patent: September 22, 1981Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Masuo Koizumi, Kazuo Sasahara, Yasushi Murakami, Sakae Wada, Hiroshi Nakakimura, Noboru Kubodera, Shun-Ichi Hata
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Patent number: 4092426Abstract: An aminobenzoic acid derivative represented by the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are defined hereinbelow, which has excellent activity for improving liver function and for potentiating and normalizing immunity; a process for preparing the same; and a pharmaceutical composition containing the same are disclosed.Type: GrantFiled: June 1, 1976Date of Patent: May 30, 1978Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Mitsuru Tanemura, Teizo Shinozaki, Minoru Shindo, Shun-ichi Hata, Koji Mizuno, Masayoshi Ono, Kiyoshige Wakabayashi, Toshiaki Nakano, Yasuho Nishii, Takashi Matsuno, Yoshiyuki Ohsugi
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Patent number: 4058601Abstract: A pharmaceutical composition for reducing the alcohol content or slowing the rate of increase thereof in the blood and inhibiting the accumulation of neutral lipid in the liver containing a uridine diphosphate as an effective ingredient and a method of the use thereof are disclosed.Type: GrantFiled: July 1, 1975Date of Patent: November 15, 1977Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Shun-ichi Hata, Koji Mizuno, Yasuho Nishii, Etsuko Mitsuishi, Motoharu Shiba
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Patent number: 4027017Abstract: A pharmaceutical composition for treating alcoholism containing a uridine diphosphate glucuronic acid as an effective ingredient and a method of the use thereof are disclosed.Type: GrantFiled: July 7, 1975Date of Patent: May 31, 1977Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Shun-ichi Hata, Koji Mizuno, Yasuho Nishii, Etsuko Mitsuishi, Motoharu Shiba
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Patent number: 4011219Abstract: Phthalazine derivatives represented by the formula ##STR1## and salts thereof which are useful for a luminescence immuno assay, or a process for preparing the same are disclosed.Type: GrantFiled: March 28, 1975Date of Patent: March 8, 1977Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Yasuho Nishii, Shun-ichi Hata, Kiyoshige Wakabayashi, Koji Mizuno, Akio Yoshida, Minoru Shindo
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Patent number: 3949069Abstract: A novel nitrogen-containing carbohydrate can be obtained from a proliferating tissue. The carbohydrate has an activity against transplanted Krebs-2 and Sarcoma-180 tumors in mice and also may be used as a diagnostic ingredient for the detection of such tumors.Type: GrantFiled: March 22, 1974Date of Patent: April 6, 1976Assignee: Chugai Seiyaku Kabushiki KaishaInventor: Shun-ichi Hata