Patents by Inventor Shun KUMANO

Shun KUMANO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240038524
    Abstract: The present disclosure proposes a mass spectrometer including a linear ion trap section and an analyzer that analyzes the ions ejected from the linear ion trap section having a multipole rod electrode including a plurality of segments arranged in a direction of a center axis of the linear ion trap section. A first radio frequency voltage in opposite phase is applied to adjacent rod electrodes. An electrostatic voltage having the same amplitude and a second radio frequency voltage are applied to the segments having the same position in the direction of the center axis. The electrostatic voltage is applied to the segments such that the electrostatic voltage decreases from an inlet to an outlet of the linear ion trap section. The second radio frequency voltage is applied to the segments such that the second radio frequency voltage increases from the inlet to the outlet of the linear ion trap section.
    Type: Application
    Filed: June 26, 2023
    Publication date: February 1, 2024
    Inventors: Masuyuki SUGIYAMA, Shun KUMANO, Akihiro NOJIMA
  • Publication number: 20230416301
    Abstract: Provided is a pretreatment method for structural analysis of a protein, including chemical modifying and fragmenting a protein to be analyzed, in which in the fragmenting, the protein is treated at a temperature of 60 to 99° C. in the presence of a heat-resistant protease that has four or more cleavage sites and is soluble or immobilized on a carrier.
    Type: Application
    Filed: April 13, 2023
    Publication date: December 28, 2023
    Applicant: HITACHI, LTD.
    Inventors: Masashi Maruyama, Eric Ofosu-Twum, Akihiro Nojima, Masuyuki Sugiyama, Shun Kumano
  • Patent number: 11776800
    Abstract: A substance analyzer that includes, to enhance selectivity of substance analysis, the following: a heater that heats a medium for collecting a chemical substance adhering to a surface of an inspection object; a mass spectrometer that performs tandem mass spectrometry of vapor derived from the chemical substance heated and vaporized by the heater from the medium; and a control device that causes the mass spectrometer to perform, based on a temperature of the medium in the heater, tandem mass spectrometry for the chemical substance that is vaporized at the temperature of the medium using the vapor sent from the heater to the mass spectrometer.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: October 3, 2023
    Assignee: Hitachi High-Tech Corporation
    Inventors: Yasuaki Takada, Shun Kumano, Masuyuki Sugiyama, Tsukasa Shishika, Shinji Yoshioka, Akimasa Osaka
  • Publication number: 20220373434
    Abstract: An attached substance collection device comprising, a nozzle configured to jet gas upward, a surface equipped with an opening portion through which the gas jets, a collection opening through which the gas jetted toward an inspection object is collected, and a contact detection sensor configured to detect whether or not the inspection object has come into contact with the upper surface, wherein an attached substance attached to the inspection object is collected by using the gas, a height of a distal end of the nozzle is substantially equal to a height of the surface; or equal to or less than a height of the surface, the surface includes a recess portion, and, relative to a jet opening of the nozzle, the recess portion is closer to the collection opening, and is in contact with the jet opening of the nozzle or includes the jet opening of the nozzle.
    Type: Application
    Filed: June 17, 2020
    Publication date: November 24, 2022
    Inventors: Shun KUMANO, Yasuaki TAKADA, Tatsuo NOJIRI, Hisashi NAGANO, Hiroki MIZUNO, Takayuki FUJII
  • Publication number: 20220359182
    Abstract: A substance analyzer that includes, to enhance selectivity of substance analysis, the following: a heater that heats a medium for collecting a chemical substance adhering to a surface of an inspection object; a mass spectrometer that performs tandem mass spectrometry of vapor derived from the chemical substance heated and vaporized by the heater from the medium; and a control device that causes the mass spectrometer to perform, based on a temperature of the medium in the heater, tandem mass spectrometry for the chemical substance that is vaporized at the temperature of the medium using the vapor sent from the heater to the mass spectrometer.
    Type: Application
    Filed: June 20, 2019
    Publication date: November 10, 2022
    Applicant: Hitachi High-Tech Corporation
    Inventors: Yasuaki TAKADA, Shun KUMANO, Masuyuki SUGIYAMA, Tsukasa SHISHIKA, Shinji YOSHIOKA, Akimasa OSAKA
  • Patent number: 11371915
    Abstract: In order to detach substances stably from an inspection object, an adhering substance collecting device includes: ejection openings configured to eject gas; a housing on which the ejection openings are provided; and supporting portions which are installed on a surface of the housing on which the ejection openings are provided, and have a prescribed height. The supporting portions include protruded portions formed on the housing. The supporting portions each have a cuboid shape, and are installed such that a distance therebetween becomes smaller toward a direction of a recovery opening that is configured to collect substances having been detached from an inspection object, from the gas.
    Type: Grant
    Filed: May 29, 2017
    Date of Patent: June 28, 2022
    Assignee: Hitachi, Ltd.
    Inventors: Shun Kumano, Masuyuki Sugiyama, Hisashi Nagano, Makoto Namai, Takahiro Itou
  • Patent number: 11101121
    Abstract: For increasing a speed of fragmentation of a sample, such as a protein and a peptide, to enhance introduction efficiency into a detector, such as a mass spectrometer, a liquid feeding pump 2, a sample injector 3, and a separation column 6 that are connected via pipes are included, and further, a heating unit 4 for heating a pipe between the sample injector 3 and the separation column 6, and a pressure regulating unit 5 provided between the heating unit 4 and the separation column 6 for regulating the inner pressure of the pipe heated by the heating unit 4, are included.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: August 24, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Hideki Hasegawa, Shun Kumano, Yuichiro Hashimoto
  • Patent number: 10989632
    Abstract: An object of the invention is to improve uniformity of a standard sample used for evaluating a gas flow type analysis system. The invention includes weighing a background into a container; adding a sample solution to the background; drying the sample solution; adding a solvent that can dissolve the sample into the container; and drying the solvent added to the container. The invention is also characterized in that the solvent is an organic solvent, in particular, acetone.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: April 27, 2021
    Assignee: Hitachi, Ltd.
    Inventors: Yasuaki Takada, Shun Kumano, Masuyuki Sugiyama, Hisashi Nagano, Tatsuo Nojiri, Hiroki Mizuno, Yuichiro Hashimoto
  • Publication number: 20200319061
    Abstract: In order to detach substances stably from an inspection object, an adhering substance collecting device includes: ejection openings configured to eject gas; a housing on which the ejection openings are provided; and supporting portions which are installed on a surface of the housing on which the ejection openings are provided, and have a prescribed height. The supporting portions include protruded portions formed on the housing. The supporting portions each have a cuboid shape, and are installed such that a distance therebetween becomes smaller toward a direction of a recovery opening that is configured to collect substances having been detached from an inspection object, from the gas.
    Type: Application
    Filed: May 29, 2017
    Publication date: October 8, 2020
    Inventors: Shun KUMANO, Masuyuki SUGIYAMA, Hisashi NAGANO, Makoto NAMAI, Takahiro ITOU
  • Publication number: 20200193545
    Abstract: To achieve inspection with both a high security level and high throughput, the present invention comprises: a step of acquiring personal information of a subject; a step of calculating a terrorism risk of the subject by referring the acquired personal information to a database storing a relationship between the personal information and the terrorism risk; and a step of using an inspection device for collecting an adhered matter on the subject or on an inspection object carried by the subject and/or a vapor from the adhered matter, ionizing and analyzing the collected matter, and determining whether or not the adhered matter is a dangerous material by referring the analysis result to the database; wherein inspection condition and/or judgement condition of the inspection device is changed on a per-subject basis so that a true positive rate of an inspection is varied according to a level of the calculated terrorism risk.
    Type: Application
    Filed: January 16, 2018
    Publication date: June 18, 2020
    Inventors: Shun KUMANO, Yuichiro HASHIMOTO, Masuyuki SUGIYAMA, Yasuaki TAKADA
  • Publication number: 20180196017
    Abstract: Provided is a chemical analysis apparatus configured to quickly quantify and detect target molecules at low costs with high-sensitivity. A chemical analysis apparatus 600 includes a pretreating unit 60 in which a capturing body 61 that captures a target molecule using a molecularly imprinted polymer interacting with the target molecule included in a specimen is accommodated, a specimen introducing unit 62 that supplies the specimen to the pretreating unit 60, a desorbing liquid supplying unit 67 that supplies a desorbing liquid, which desorbs the target molecule from the capturing body 61, to the pretreating unit 60, and a quantifying unit 65 that quantifies the target molecules desorbed from the capturing body 61 using the desorbing liquid.
    Type: Application
    Filed: September 14, 2015
    Publication date: July 12, 2018
    Inventors: Shinichi TANIGUCHI, Shun KUMANO, Yuichiro HASHIMOTO
  • Publication number: 20180149563
    Abstract: An object of the invention is to improve uniformity of a standard sample used for evaluating a gas flow type analysis system. The invention includes weighing a background into a container; adding a sample solution to the background; drying the sample solution; adding a solvent that can dissolve the sample into the container; and drying the solvent added to the container. The invention is also characterized in that the solvent is an organic solvent, in particular, acetone.
    Type: Application
    Filed: November 27, 2017
    Publication date: May 31, 2018
    Inventors: Yasuaki TAKADA, Shun KUMANO, Masuyuki SUGIYAMA, Hisashi NAGANO, Tatsuo NOJIRI, Hiroki MIZUNO, Yuichiro HASHIMOTO
  • Publication number: 20180114682
    Abstract: For increasing a speed of fragmentation of a sample, such as a protein and a peptide, to enhance introduction efficiency into a detector, such as a mass spectrometer, a liquid feeding pump 2, a sample injector 3, and a separation column 6 that are connected via pipes are included, and further, a heating unit 4 for heating a pipe between the sample injector 3 and the separation column 6, and a pressure regulating unit 5 provided between the heating unit 4 and the separation column 6 for regulating the inner pressure of the pipe heated by the heating unit 4, are included.
    Type: Application
    Filed: March 30, 2016
    Publication date: April 26, 2018
    Inventors: Hideki HASEGAWA, Shun KUMANO, Yuichiro HASHIMOTO
  • Patent number: 9543135
    Abstract: A mass spectrometer for efficiently ionizing a sample with less carry-over. The ratio of the amount of sample gas to that of a whole headspace gas is increased by decreasing the pressure inside of a sample vessel in which the sample is sealed thereby efficiently ionizing the sample.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: January 10, 2017
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Shun Kumano, Masuyuki Sugiyama, Yuichiro Hashimoto, Hideki Hasegawa, Masuyoshi Yamada, Kazushige Nishimura, Hidetoshi Morokuma
  • Patent number: 9287105
    Abstract: There is a tendency of the intensity and the shape of a spectrum to be measured transitioning with the passage of measured time, depending on the volatility and the reactivity of a component. A mass spectrometric system includes: a mass spectrometric unit that measures a specimen and outputs a mass spectrum; and an estimator that has an estimation rule on content information, the estimation rule being assigned to each component and each measurement time. The estimator estimates, based on a mass spectrum output from the mass spectrometric unit, content information on each component of a plurality of components that may be contained in the specimen in accordance with the estimation rule.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: March 15, 2016
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Yohei Kawaguchi, Yuichiro Hashimoto, Masuyuki Sugiyama, Shun Kumano, Akihito Kaneko, Masahito Togami, Kazushige Nishimura, Hiroyuki Inoue
  • Patent number: 9281169
    Abstract: Provided is a mass spectrometer capable of easy exchange of a measurement sample and suppressing a carryover. The mass spectrometer includes a mass spectrometry section, an ion source the internal pressure of which is reduced by a differential pumping from the mass spectrometry section and the ion source ionizes the sample gas, a sample container in which the sample gas is generated by vaporizing the measurement sample, a thin pipe that introduces the sample gas generated in the sample container into the ion source, an elastic tube of openable and closable that connects the sample container and the thin pipe, a pair of weirs that closes or opens the elastic tube so as to sandwich the elastic tube, and a cartridge that integrates the sample container, the thin pipe, and the elastic tube, and is detachable in a lump from a main body of the mass spectrometer.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: March 8, 2016
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Hidetoshi Morokuma, Koji Ishiguro, Shun Kumano
  • Patent number: 9184037
    Abstract: A mass spectrometer including a sample attaching member of attaching a sample, an ionizing chamber including an introductory port of the sample attaching member and an ionization source of generating a sample ion, a vacuumed chamber having a mass analyzer of analyzing the sample ion, and an opening/closing mechanism provided between the ionizing chamber and the vacuumed chamber, in which the opening/closing mechanism is controlled from a closed state to an open state after introducing the sample attaching member into the ionizing chamber to thereby enable to perform ionization with inconsiderable fragmentation at a high sensitivity with a high throughput.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: November 10, 2015
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Shun Kumano, Masuyuki Sugiyama, Yuichiro Hashimoto, Hideki Hasegawa, Masuyoshi Yamada, Hidetoshi Morokuma, Shuhei Hashiba
  • Patent number: 9076638
    Abstract: A variation in an ionization efficiency and the amount of sample which is introduced into an ion trap is corrected and quantified. Ions of an internal standard and ions of a sample are trapped in the ion trap at the same time, and a concentration of the sample is quantified according to an intensity of the ions of the internal standard which are mass-selectively ejected, and an intensity of fragment ions of the sample.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: July 7, 2015
    Assignee: HITACHI-HIGH TECHNOLOGIES CORPORATION
    Inventors: Masuyuki Sugiyama, Yuichiro Hashimoto, Hideki Hasegawa, Shuhei Hashiba, Shun Kumano
  • Publication number: 20150187554
    Abstract: Provided is a mass spectrometer capable of easy exchange of a measurement sample and suppressing a carryover. The mass spectrometer includes a mass spectrometry section, an ion source the internal pressure of which is reduced by a differential pumping from the mass spectrometry section and the ion source ionizes the sample gas, a sample container in which the sample gas is generated by vaporizing the measurement sample, a thin pipe that introduces the sample gas generated in the sample container into the ion source, an elastic tube of openable and closable that connects the sample container and the thin pipe, a pair of weirs that closes or opens the elastic tube so as to sandwich the elastic tube, and a cartridge that integrates the sample container, the thin pipe, and the elastic tube, and is detachable in a lump from a main body of the mass spectrometer.
    Type: Application
    Filed: March 10, 2015
    Publication date: July 2, 2015
    Inventors: Hidetoshi MOROKUMA, Koji ISHIGURO, Shun KUMANO
  • Patent number: 9006679
    Abstract: Provided is a mass spectrometer capable of easy exchange of a measurement sample and suppressing a carryover. The mass spectrometer includes a mass spectrometry section, an ion source the internal pressure of which is reduced by a differential pumping from the mass spectrometry section and the ion source ionizes the sample gas, a sample container in which the sample gas is generated by vaporizing the measurement sample, a thin pipe that introduces the sample gas generated in the sample container into the ion source, an elastic tube of openable and closable that connects the sample container and the thin pipe, a pair of weirs that closes or opens the elastic tube so as to sandwich the elastic tube, and a cartridge that integrates the sample container, the thin pipe, and the elastic tube, and is detachable in a lump from a main body of the mass spectrometer.
    Type: Grant
    Filed: June 4, 2013
    Date of Patent: April 14, 2015
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hidetoshi Morokuma, Koji Ishiguro, Shun Kumano