Patents by Inventor Shun KUMANO
Shun KUMANO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240038524Abstract: The present disclosure proposes a mass spectrometer including a linear ion trap section and an analyzer that analyzes the ions ejected from the linear ion trap section having a multipole rod electrode including a plurality of segments arranged in a direction of a center axis of the linear ion trap section. A first radio frequency voltage in opposite phase is applied to adjacent rod electrodes. An electrostatic voltage having the same amplitude and a second radio frequency voltage are applied to the segments having the same position in the direction of the center axis. The electrostatic voltage is applied to the segments such that the electrostatic voltage decreases from an inlet to an outlet of the linear ion trap section. The second radio frequency voltage is applied to the segments such that the second radio frequency voltage increases from the inlet to the outlet of the linear ion trap section.Type: ApplicationFiled: June 26, 2023Publication date: February 1, 2024Inventors: Masuyuki SUGIYAMA, Shun KUMANO, Akihiro NOJIMA
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Publication number: 20230416301Abstract: Provided is a pretreatment method for structural analysis of a protein, including chemical modifying and fragmenting a protein to be analyzed, in which in the fragmenting, the protein is treated at a temperature of 60 to 99° C. in the presence of a heat-resistant protease that has four or more cleavage sites and is soluble or immobilized on a carrier.Type: ApplicationFiled: April 13, 2023Publication date: December 28, 2023Applicant: HITACHI, LTD.Inventors: Masashi Maruyama, Eric Ofosu-Twum, Akihiro Nojima, Masuyuki Sugiyama, Shun Kumano
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Patent number: 11776800Abstract: A substance analyzer that includes, to enhance selectivity of substance analysis, the following: a heater that heats a medium for collecting a chemical substance adhering to a surface of an inspection object; a mass spectrometer that performs tandem mass spectrometry of vapor derived from the chemical substance heated and vaporized by the heater from the medium; and a control device that causes the mass spectrometer to perform, based on a temperature of the medium in the heater, tandem mass spectrometry for the chemical substance that is vaporized at the temperature of the medium using the vapor sent from the heater to the mass spectrometer.Type: GrantFiled: June 20, 2019Date of Patent: October 3, 2023Assignee: Hitachi High-Tech CorporationInventors: Yasuaki Takada, Shun Kumano, Masuyuki Sugiyama, Tsukasa Shishika, Shinji Yoshioka, Akimasa Osaka
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Publication number: 20220373434Abstract: An attached substance collection device comprising, a nozzle configured to jet gas upward, a surface equipped with an opening portion through which the gas jets, a collection opening through which the gas jetted toward an inspection object is collected, and a contact detection sensor configured to detect whether or not the inspection object has come into contact with the upper surface, wherein an attached substance attached to the inspection object is collected by using the gas, a height of a distal end of the nozzle is substantially equal to a height of the surface; or equal to or less than a height of the surface, the surface includes a recess portion, and, relative to a jet opening of the nozzle, the recess portion is closer to the collection opening, and is in contact with the jet opening of the nozzle or includes the jet opening of the nozzle.Type: ApplicationFiled: June 17, 2020Publication date: November 24, 2022Inventors: Shun KUMANO, Yasuaki TAKADA, Tatsuo NOJIRI, Hisashi NAGANO, Hiroki MIZUNO, Takayuki FUJII
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Publication number: 20220359182Abstract: A substance analyzer that includes, to enhance selectivity of substance analysis, the following: a heater that heats a medium for collecting a chemical substance adhering to a surface of an inspection object; a mass spectrometer that performs tandem mass spectrometry of vapor derived from the chemical substance heated and vaporized by the heater from the medium; and a control device that causes the mass spectrometer to perform, based on a temperature of the medium in the heater, tandem mass spectrometry for the chemical substance that is vaporized at the temperature of the medium using the vapor sent from the heater to the mass spectrometer.Type: ApplicationFiled: June 20, 2019Publication date: November 10, 2022Applicant: Hitachi High-Tech CorporationInventors: Yasuaki TAKADA, Shun KUMANO, Masuyuki SUGIYAMA, Tsukasa SHISHIKA, Shinji YOSHIOKA, Akimasa OSAKA
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Patent number: 11371915Abstract: In order to detach substances stably from an inspection object, an adhering substance collecting device includes: ejection openings configured to eject gas; a housing on which the ejection openings are provided; and supporting portions which are installed on a surface of the housing on which the ejection openings are provided, and have a prescribed height. The supporting portions include protruded portions formed on the housing. The supporting portions each have a cuboid shape, and are installed such that a distance therebetween becomes smaller toward a direction of a recovery opening that is configured to collect substances having been detached from an inspection object, from the gas.Type: GrantFiled: May 29, 2017Date of Patent: June 28, 2022Assignee: Hitachi, Ltd.Inventors: Shun Kumano, Masuyuki Sugiyama, Hisashi Nagano, Makoto Namai, Takahiro Itou
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Patent number: 11101121Abstract: For increasing a speed of fragmentation of a sample, such as a protein and a peptide, to enhance introduction efficiency into a detector, such as a mass spectrometer, a liquid feeding pump 2, a sample injector 3, and a separation column 6 that are connected via pipes are included, and further, a heating unit 4 for heating a pipe between the sample injector 3 and the separation column 6, and a pressure regulating unit 5 provided between the heating unit 4 and the separation column 6 for regulating the inner pressure of the pipe heated by the heating unit 4, are included.Type: GrantFiled: March 30, 2016Date of Patent: August 24, 2021Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Hideki Hasegawa, Shun Kumano, Yuichiro Hashimoto
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Patent number: 10989632Abstract: An object of the invention is to improve uniformity of a standard sample used for evaluating a gas flow type analysis system. The invention includes weighing a background into a container; adding a sample solution to the background; drying the sample solution; adding a solvent that can dissolve the sample into the container; and drying the solvent added to the container. The invention is also characterized in that the solvent is an organic solvent, in particular, acetone.Type: GrantFiled: November 27, 2017Date of Patent: April 27, 2021Assignee: Hitachi, Ltd.Inventors: Yasuaki Takada, Shun Kumano, Masuyuki Sugiyama, Hisashi Nagano, Tatsuo Nojiri, Hiroki Mizuno, Yuichiro Hashimoto
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Publication number: 20200319061Abstract: In order to detach substances stably from an inspection object, an adhering substance collecting device includes: ejection openings configured to eject gas; a housing on which the ejection openings are provided; and supporting portions which are installed on a surface of the housing on which the ejection openings are provided, and have a prescribed height. The supporting portions include protruded portions formed on the housing. The supporting portions each have a cuboid shape, and are installed such that a distance therebetween becomes smaller toward a direction of a recovery opening that is configured to collect substances having been detached from an inspection object, from the gas.Type: ApplicationFiled: May 29, 2017Publication date: October 8, 2020Inventors: Shun KUMANO, Masuyuki SUGIYAMA, Hisashi NAGANO, Makoto NAMAI, Takahiro ITOU
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Publication number: 20200193545Abstract: To achieve inspection with both a high security level and high throughput, the present invention comprises: a step of acquiring personal information of a subject; a step of calculating a terrorism risk of the subject by referring the acquired personal information to a database storing a relationship between the personal information and the terrorism risk; and a step of using an inspection device for collecting an adhered matter on the subject or on an inspection object carried by the subject and/or a vapor from the adhered matter, ionizing and analyzing the collected matter, and determining whether or not the adhered matter is a dangerous material by referring the analysis result to the database; wherein inspection condition and/or judgement condition of the inspection device is changed on a per-subject basis so that a true positive rate of an inspection is varied according to a level of the calculated terrorism risk.Type: ApplicationFiled: January 16, 2018Publication date: June 18, 2020Inventors: Shun KUMANO, Yuichiro HASHIMOTO, Masuyuki SUGIYAMA, Yasuaki TAKADA
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Publication number: 20180196017Abstract: Provided is a chemical analysis apparatus configured to quickly quantify and detect target molecules at low costs with high-sensitivity. A chemical analysis apparatus 600 includes a pretreating unit 60 in which a capturing body 61 that captures a target molecule using a molecularly imprinted polymer interacting with the target molecule included in a specimen is accommodated, a specimen introducing unit 62 that supplies the specimen to the pretreating unit 60, a desorbing liquid supplying unit 67 that supplies a desorbing liquid, which desorbs the target molecule from the capturing body 61, to the pretreating unit 60, and a quantifying unit 65 that quantifies the target molecules desorbed from the capturing body 61 using the desorbing liquid.Type: ApplicationFiled: September 14, 2015Publication date: July 12, 2018Inventors: Shinichi TANIGUCHI, Shun KUMANO, Yuichiro HASHIMOTO
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Publication number: 20180149563Abstract: An object of the invention is to improve uniformity of a standard sample used for evaluating a gas flow type analysis system. The invention includes weighing a background into a container; adding a sample solution to the background; drying the sample solution; adding a solvent that can dissolve the sample into the container; and drying the solvent added to the container. The invention is also characterized in that the solvent is an organic solvent, in particular, acetone.Type: ApplicationFiled: November 27, 2017Publication date: May 31, 2018Inventors: Yasuaki TAKADA, Shun KUMANO, Masuyuki SUGIYAMA, Hisashi NAGANO, Tatsuo NOJIRI, Hiroki MIZUNO, Yuichiro HASHIMOTO
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Publication number: 20180114682Abstract: For increasing a speed of fragmentation of a sample, such as a protein and a peptide, to enhance introduction efficiency into a detector, such as a mass spectrometer, a liquid feeding pump 2, a sample injector 3, and a separation column 6 that are connected via pipes are included, and further, a heating unit 4 for heating a pipe between the sample injector 3 and the separation column 6, and a pressure regulating unit 5 provided between the heating unit 4 and the separation column 6 for regulating the inner pressure of the pipe heated by the heating unit 4, are included.Type: ApplicationFiled: March 30, 2016Publication date: April 26, 2018Inventors: Hideki HASEGAWA, Shun KUMANO, Yuichiro HASHIMOTO
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Patent number: 9543135Abstract: A mass spectrometer for efficiently ionizing a sample with less carry-over. The ratio of the amount of sample gas to that of a whole headspace gas is increased by decreasing the pressure inside of a sample vessel in which the sample is sealed thereby efficiently ionizing the sample.Type: GrantFiled: July 31, 2012Date of Patent: January 10, 2017Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Shun Kumano, Masuyuki Sugiyama, Yuichiro Hashimoto, Hideki Hasegawa, Masuyoshi Yamada, Kazushige Nishimura, Hidetoshi Morokuma
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Patent number: 9287105Abstract: There is a tendency of the intensity and the shape of a spectrum to be measured transitioning with the passage of measured time, depending on the volatility and the reactivity of a component. A mass spectrometric system includes: a mass spectrometric unit that measures a specimen and outputs a mass spectrum; and an estimator that has an estimation rule on content information, the estimation rule being assigned to each component and each measurement time. The estimator estimates, based on a mass spectrum output from the mass spectrometric unit, content information on each component of a plurality of components that may be contained in the specimen in accordance with the estimation rule.Type: GrantFiled: February 6, 2013Date of Patent: March 15, 2016Assignee: Hitachi High-Technologies CorporationInventors: Yohei Kawaguchi, Yuichiro Hashimoto, Masuyuki Sugiyama, Shun Kumano, Akihito Kaneko, Masahito Togami, Kazushige Nishimura, Hiroyuki Inoue
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Patent number: 9281169Abstract: Provided is a mass spectrometer capable of easy exchange of a measurement sample and suppressing a carryover. The mass spectrometer includes a mass spectrometry section, an ion source the internal pressure of which is reduced by a differential pumping from the mass spectrometry section and the ion source ionizes the sample gas, a sample container in which the sample gas is generated by vaporizing the measurement sample, a thin pipe that introduces the sample gas generated in the sample container into the ion source, an elastic tube of openable and closable that connects the sample container and the thin pipe, a pair of weirs that closes or opens the elastic tube so as to sandwich the elastic tube, and a cartridge that integrates the sample container, the thin pipe, and the elastic tube, and is detachable in a lump from a main body of the mass spectrometer.Type: GrantFiled: March 10, 2015Date of Patent: March 8, 2016Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Hidetoshi Morokuma, Koji Ishiguro, Shun Kumano
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Patent number: 9184037Abstract: A mass spectrometer including a sample attaching member of attaching a sample, an ionizing chamber including an introductory port of the sample attaching member and an ionization source of generating a sample ion, a vacuumed chamber having a mass analyzer of analyzing the sample ion, and an opening/closing mechanism provided between the ionizing chamber and the vacuumed chamber, in which the opening/closing mechanism is controlled from a closed state to an open state after introducing the sample attaching member into the ionizing chamber to thereby enable to perform ionization with inconsiderable fragmentation at a high sensitivity with a high throughput.Type: GrantFiled: June 20, 2012Date of Patent: November 10, 2015Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Shun Kumano, Masuyuki Sugiyama, Yuichiro Hashimoto, Hideki Hasegawa, Masuyoshi Yamada, Hidetoshi Morokuma, Shuhei Hashiba
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Patent number: 9076638Abstract: A variation in an ionization efficiency and the amount of sample which is introduced into an ion trap is corrected and quantified. Ions of an internal standard and ions of a sample are trapped in the ion trap at the same time, and a concentration of the sample is quantified according to an intensity of the ions of the internal standard which are mass-selectively ejected, and an intensity of fragment ions of the sample.Type: GrantFiled: February 3, 2012Date of Patent: July 7, 2015Assignee: HITACHI-HIGH TECHNOLOGIES CORPORATIONInventors: Masuyuki Sugiyama, Yuichiro Hashimoto, Hideki Hasegawa, Shuhei Hashiba, Shun Kumano
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Publication number: 20150187554Abstract: Provided is a mass spectrometer capable of easy exchange of a measurement sample and suppressing a carryover. The mass spectrometer includes a mass spectrometry section, an ion source the internal pressure of which is reduced by a differential pumping from the mass spectrometry section and the ion source ionizes the sample gas, a sample container in which the sample gas is generated by vaporizing the measurement sample, a thin pipe that introduces the sample gas generated in the sample container into the ion source, an elastic tube of openable and closable that connects the sample container and the thin pipe, a pair of weirs that closes or opens the elastic tube so as to sandwich the elastic tube, and a cartridge that integrates the sample container, the thin pipe, and the elastic tube, and is detachable in a lump from a main body of the mass spectrometer.Type: ApplicationFiled: March 10, 2015Publication date: July 2, 2015Inventors: Hidetoshi MOROKUMA, Koji ISHIGURO, Shun KUMANO
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Patent number: 9006679Abstract: Provided is a mass spectrometer capable of easy exchange of a measurement sample and suppressing a carryover. The mass spectrometer includes a mass spectrometry section, an ion source the internal pressure of which is reduced by a differential pumping from the mass spectrometry section and the ion source ionizes the sample gas, a sample container in which the sample gas is generated by vaporizing the measurement sample, a thin pipe that introduces the sample gas generated in the sample container into the ion source, an elastic tube of openable and closable that connects the sample container and the thin pipe, a pair of weirs that closes or opens the elastic tube so as to sandwich the elastic tube, and a cartridge that integrates the sample container, the thin pipe, and the elastic tube, and is detachable in a lump from a main body of the mass spectrometer.Type: GrantFiled: June 4, 2013Date of Patent: April 14, 2015Assignee: Hitachi High-Technologies CorporationInventors: Hidetoshi Morokuma, Koji Ishiguro, Shun Kumano