Abstract: Antigen-binding domains that are capable of binding to CD3 and CD137 but do not bind to CD3 and CD137 at the same time and methods of using the same are provided. Methods to obtain antigen binding domains which bind to two or more different antigen more efficiently are also provided.

Abstract: A detection device has: a case member; a cover member; a substrate, provided in a space surrounded by the case member and the cover member, the substrate having mounted thereon a wireless communication circuit and a sensor configured to measure a physical quantity; a battery housed in the space; and a metal pedestal part disposed in the space on a same side as the case member, the pedestal part has an end portion facing the sensor in the space, and the battery is housed in part of the space that is on a same side as the pedestal part with respect to the substrate.

Abstract: A movement member which reciprocates includes a thick portion and a thin portion, a bearing portion formed in the thick portion is slidingly supported by the guide shaft, and a sliding portion formed in the thin portion is slidingly guided by the sliding guide portion. Power of the motor is transmitted to a pinion gear via a speed reduction gear and a speed reduction mechanism inside a gear box, and a movement reaction force is applied from the pinion gear to the rack portion. Since the rack portion is positioned on an axis Os, a force is effectively applied to the movement member by the power from the motor.

Abstract: An operating device includes a moving member that reciprocates, a motor that applies a force for moving forward and a force for moving rearward to the moving member, a position sensing unit that detects a position to which the moving member is moved, and a control device that varies a load applied to the motor in accordance with an output signal from the position sensing unit. According to the operating device, a reaction force that acts on a finger or the like can be changed in accordance with the position of the moving member that is operated by using a hand or the finger.

Abstract: A left electronic-component compartment has a left FPC receiving port, through which a flexible printed circuit (FPC) is inserted into the left electronic-component compartment, located adjacent to a left hinge. In the left electronic-component compartment, a left waterproof member is fitted adjacent to a left connector, which serves as a connection between the FPC and a battery. The left waterproof member prevents moisture, dust, and other foreign matter from entering the battery. A right electronic-component compartment has a right FPC receiving port, through which the FPC is inserted into the right electronic-component compartment, located adjacent to a right hinge. In the right electronic-component compartment, a right waterproof member is fitted adjacent to a right connector, serving as a connection between the FPC and electric circuitry. The right waterproof member prevents moisture, dust, and other foreign matter from entering the electric circuitry.

Abstract: An FPC compartment in a left rim is slit-shaped. A left FPC positioning member supports a flexible printed circuit (FPC) in the FPC compartment such that a main surface of the FPC extends substantially horizontally. The FPC supported in the FPC compartment is twisted by substantially 90° at an entrance to a left hinge. The FPC extends around a hinge pin and is received in a left electronic-component compartment. The FPC is held in the left electronic-component compartment such that the main surface of the FPC extends substantially vertically. A left end piece located adjacent to the left hinge has a left cavity accommodating a left deformable bend of the FPC.

Abstract: A left electronic-component compartment has a left FPC receiving port, through which a flexible printed circuit (FPC) is inserted into the left electronic-component compartment, located adjacent to a left hinge. In the left electronic-component compartment, a left waterproof member is fitted adjacent to a left connector, which serves as a connection between the FPC and a battery. The left waterproof member prevents moisture, dust, and other foreign matter from entering the battery. A right electronic-component compartment has a right FPC receiving port, through which the FPC is inserted into the right electronic-component compartment, located adjacent to a right hinge. In the right electronic-component compartment, a right waterproof member is fitted adjacent to a right connector, serving as a connection between the FPC and electric circuitry. The right waterproof member prevents moisture, dust, and other foreign matter from entering the electric circuitry.

Abstract: An FPC compartment in a left rim is slit-shaped. A left FPC positioning member supports a flexible printed circuit (FPC) in the FPC compartment such that a main surface of the FPC extends substantially horizontally. The FPC supported in the FPC compartment is twisted by substantially 90° at an entrance to a left hinge. The FPC extends around a hinge pin and is received in a left electronic-component compartment. The FPC is held in the left electronic-component compartment such that the main surface of the FPC extends substantially vertically. A left end piece located adjacent to the left hinge has a left cavity accommodating a left deformable bend of the FPC.

Abstract: A movement member which reciprocates includes a thick portion and a thin portion, a bearing portion formed in the thick portion is slidingly supported by the guide shaft, and a sliding portion formed in the thin portion is slidingly guided by the sliding guide portion. Power of the motor is transmitted to a pinion gear via a speed reduction gear and a speed reduction mechanism inside a gear box, and a movement reaction force is applied from the pinion gear to the rack portion. Since the rack portion is positioned on an axis Os, a force is effectively applied to the movement member by the power from the motor.

Abstract: An operating device includes a moving member that reciprocates, a motor that applies a force for moving forward and a force for moving rearward to the moving member, a position sensing unit that detects a position to which the moving member is moved, and a control device that varies a load applied to the motor in accordance with an output signal from the position sensing unit. According to the operating device, a reaction force that acts on a finger or the like can be changed in accordance with the position of the moving member that is operated by using a hand or the finger.