Abstract: Methods are provided herein for synergistically affecting tumor growth in a subject, involving the administration to the subject of an agent that blocks the TGF-? signaling pathway in combination with an immunogenic agent. The agent that blocks the TGF-? signaling pathway is believed to inhibit the immunosuppressive effects of TGF-?, while the immunogenic agent is believed to enhance an immune response. Surprisingly, the combination of such elements produces a synergistic effect. In one embodiment, the administration of the 1D11.16 anti-TGF-? antibody in combination with the human papilloma virus E7(49-57) peptide enhances tumor regression and tumor-specific CTL response in the subject. In another embodiment, the administration of the 1D11.16 anti-TGF-? antibody in combination with irradiated CT26 cells enhances tumor regression in the subject.