Abstract: According to an ignition device, a first switching unit applies a voltage between electrodes of by spark plug by turning on/off energization from an on-vehicle battery to a primary coil. Further, a second switching unit applies a voltage having the same direction as a spark discharge generated by turning on/off the first switching unit between the electrodes of the spark plug by supplying electrical energy accumulated in a booster circuit into a primary coil. Accordingly, it is possible to greatly reduce a complexity of the on/off switching of the first and second switching units compared to a conventional technology.

Abstract: Abacavir, a nucleoside analog reverse transcriptase inhibitor, has been found to exhibit an anti-cancer activity on ATL cells in vitro without inhibiting DNA replication of normal cells. Abacavir or a pharmaceutically acceptable derivative thereof is useful as an active ingredient of a pharmaceutical composition for use in the prevention or the treatment of cancer, in particular a cancer whose DNA repair system is impaired such as breast cancer or adult T-cell leukemia.

Abstract: An ignition control apparatus of the present embodiment controls operation of an ignition plug provided so as to ignite an air-fuel mixed gas.

Abstract: Abacavir, a nucleoside analogue reverse transcriptase inhibitor, has been found to exhibit an anti-cancer activity on ATL cells in vitro without inhibiting DNA replication of normal cells. Abacavir or a pharmaceutically acceptable derivative thereof is useful as an active ingredient of a pharmaceutical composition for use in the prevention or the treatment of cancer, in particular a cancer whose DNA repair system is impaired such as breast cancer or adult T-cell leukemia.

Abstract: The invention relates to a method for preparing an antibody-producing cell line capable of directed constitutive hypermutation of a specific nucleic acid region, comprising the steps of: a) screening a clonal cell population for V gene diversity; b) isolating one or more cells which display V gene diversity and comparing the rate of accumulation of mutations in the V genes and other genes of the selected cells; and c) selecting a cell in which the rate of V gene mutation exceeds that of other gene mutation.

Abstract: The invention relates to a method for preparing an antibody-producing cell line capable of directed constitutive hypermutation of a specific nucleic acid region, comprising the steps of: a) screening a clonal cell population for V gene diversity; b) isolating one or more cells which display V gene diversity and comparing the rate of accumulation of mutations in the V genes and other genes of the selected cells; and c) selecting a cell in which the rate of V gene mutation exceeds that of other gene mutation.

Abstract: An ignition apparatus for an internal combustion engine, which is controlled by a control unit, includes a connector, an ignition coil assembly, an igniter and a capacitor. The connector is electrically connected with the control unit, and includes an input terminal, which is electrically connected with the control unit to receive an ignition signal outputted by the control unit. The connector also includes a ground terminal, which is connected with a ground. The igniter includes a switching device that switches a coil current supplied to the ignition coil assembly based on the ignition signal received from the control unit through the connector. The igniter also includes a Zener diode that serves as a protection element of the switching device. The capacitor is provided in parallel with the Zener diode between the input terminal and the ground terminal to form a parallel circuit.

Abstract: To provide a mutant Rad51 paralog gene, wherein a protein encoded thereby shows an activity for enhancing sensitivity of a cell to a DNA-damaging factor; a mutant Rad51 paralog peptide showing the activity; a transformed cell having the gene; a screening method for a drug having a DNA-damaging action, comprising contacting a test substance with the transformed cell, and evaluating a response of the cell; and a screening method for a controlling agent for DNA repair, comprising contacting a test substance with a transformed cell having the Rad51 paralog gene, and evaluating a homologous recombination repair capacity. According to the present invention, there is enabled a screening of a novel anticancer agent which allows a more efficient therapy for a cancer, wherein the agent is an agent capable of enhancing the sensitivity of a cell to an anticancer agent comprising a DNA-damaging factor or an agent having a DNA-damaging action.

Abstract: An ignition apparatus for an internal combustion engine, which is controlled by a control unit, includes a connector, an ignition coil assembly, an igniter and a capacitor. The connector is electrically connected with the control unit, and includes an input terminal, which is electrically connected with the control unit to receive an ignition signal outputted by the control unit. The connector also includes a ground terminal, which is connected with a ground. The igniter includes a switching device that switches a coil current supplied to the ignition coil assembly based on the ignition signal received from the control unit through the connector. The igniter also includes a Zener diode that serves as a protection element of the switching device. The capacitor is provided in parallel with the Zener diode between the input terminal and the ground terminal to form a parallel circuit.

Abstract: An ignition coil has a connector electrically connected to an external circuit, an igniter for accommodating a switching element adapted to cause a current supplied from the connector to be intermittent, a primary coil portion for generating a predetermined voltage by the intermittent current, a secondary coil portion for stepping up the generated voltage and applying the resulting voltage to an ignition plug, and a resin insulating material which hardens in between the primary coil portion and the secondary coil portion to ensure insulation between the primary coil portion and the secondary coil portion. An outer shell of the igniter is formed of the resin insulating material.

Abstract: An ignition coil has a connector electrically connected to an external circuit, an igniter for accommodating a switching element adapted to cause a current supplied from the connector to be intermittent, a primary coil portion for generating a predetermined voltage by the intermittent current, a secondary coil portion for stepping up the generated voltage and applying the resulting voltage to an ignition plug, and a resin insulating material which hardens in between the primary coil portion and the secondary coil portion to ensure insulation between the primary coil portion and the secondary coil portion. An outer shell of the igniter is formed of the resin insulating material.

Abstract: An ignition coil has a connector electrically connected to an external circuit, an igniter for accommodating a switching element adapted to cause a current supplied from the connector to be intermittent, a primary coil portion for generating a predetermined voltage by the intermittent current, a secondary coil portion for stepping up the generated voltage and applying the resulting voltage to an ignition plug, and a resin insulating material which hardens in between the primary coil portion and the secondary coil portion to ensure insulation between the primary coil portion and the secondary coil portion. An outer shell of the igniter is formed of the resin insulating material.

Abstract: An ignition coil has a connector electrically connected to an external circuit, an igniter for accommodating a switching element adapted to cause a current supplied from the connector to be intermittent, a primary coil portion for generating a predetermined voltage by the intermittent current, a secondary coil portion for stepping up the generated voltage and applying the resulting voltage to an ignition plug, and a resin insulating material which hardens in between the primary coil portion and the secondary coil portion to ensure insulation between the primary coil portion and the secondary coil portion. An outer shell of the igniter is formed of the resin insulating material.

Abstract: An ignition system for an internal combustion engine is disclosed.

Abstract: A double layered yarn having a sheath and core structure is prepared through a roving process, drawing process or fine spinning process. The sheath portion of the yarn is composed of staple fibers which have a high thermal shrinkage in boiling water of at least 5%, and the blended fiber ratio of which is between 50% and 25%. The core portion of the yarn is composed of staple fibers which have a property being spontaneously extensible, and the blended fiber ratio of which is between 25% and 75%. The double layered yarn is subjected to a heat treatment in hot water, and a bulky spun yarn which comprises staple fibers A and B is obtained. The staple fibers A are concentrated toward the inside of the bulky spun yarn after they are shrunk. The ends of staple fibers B are held within the inside of the bulky spun yarn, and the intermediate portions of fibers B are bulged as a loop from the body portion of the bulky spun yarn, after the fibers B are spontaneously extended.

Abstract: Novel polyester filamentary yarn is provided having (a) a fineness of 0.9 denier per filament or less, (b) an amorphous orientation in the range of 30% to 70% and (c) a negative .epsilon..sub.0.2 where said .epsilon..sub.0.2 is a structural integrity parameter. The yarn possesses ameliorated properties regarding a heat-setting property, a raising property, a dimensional stability and a twist resistance. The yarn finds its wide range of usage, for example, silky fabrics with an excellent fullness, pliability and liveliness, raised fabrics with thermally stabilized fluffs protruding straight-forwardly and an extremely soft hand, and uniformly creped fabrics with an improved surface contour are obtained therefrom.