Patents by Inventor Shunji Ichikawa
Shunji Ichikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6150355Abstract: A phenylpiperidine derivative or pharmaceutical acceptable salt thereof represented by formula (I): ##STR1## wherein X represents CH or N; Y--Z represents CH.sub.2 --O, CH.sub.2 --S, CH.sub.2 --CH.sub.2, CH.dbd.CH or CONR.sup.5 (wherein R.sup.5 represents hydrogen or lower alkyl); R.sup.1 represents hydrogen, lower alkyl, halogen, lower alkoxy or trifluoromethyl; and R.sup.2, R.sup.3 and R.sup.4 are the same or different and each represents hydrogen, lower alkyl or QR.sup.6 (wherein Q represents a single bond or lower alkylene, and R.sup.6 represents hydroxy, lower alkoxyalkoxy, lower alkoxy, lower alkylthio, nitro, halogen, lower alkanoyloxy, lower alkoxycarbonyl, lower alkanoyl or carboxyl).The present invention provides novel phenylpiperidine derivatives useful as analgesics.Type: GrantFiled: March 13, 1998Date of Patent: November 21, 2000Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Toshiaki Kumazawa, Hirokazu Koshimura, Shigeru Aono, Shunji Ichikawa, Shigeto Kitamura
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Patent number: 5789407Abstract: The present invention relates to an antidepressant containing as an active ingredient a triazine derivative or a pharmaceutically acceptable salt thereof, the derivative being represented by the following Formula (I): ##STR1## in which, R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, or substituted or unsubstituted lower alkanoyl; R.sup.2 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, or a substituted or unsubstituted heterocyclic group; R.sup.3 represents a substituted or unsubstituted heterocyclic group; X represents a single bond, O, S, S(O), S(O).sub.2, or NR.sup.4 (in which R.sup.4 represents hydrogen, or substituted or unsubstituted lower alkyl; or R.sup.2 and NR.sup.4 are combined to form a substituted or unsubstituted 4 to 6-membered saturated heterocyclic group); and A represents N or CR.sup.5 (in which R.Type: GrantFiled: April 25, 1995Date of Patent: August 4, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Fumio Suzuki, Nobuaki Koike, Junichi Shimada, Shigeto Kitamura, Shunji Ichikawa, Joji Nakamura, Shizuo Shiozaki
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Patent number: 5756735Abstract: The present invention relates to novel xanthine derivatives of the formula (I) which are selectively antagonistic to an adenosine A.sub.2 receptor, and pharmaceutically acceptable salts thereof. Formula (I): ##STR1## In the formula, R.sup.1 and R.sup.2 are the same or different and each represents a hydrogen atom, a propyl group, a butyl group or an allyl group; R.sup.3 represents a hydrogen atom or a lower alkyl group; Y.sup.1 and Y.sup.2 are the same or different and each represents a hydrogen atom or a methyl group; and Z represents a substituted or unsubstituted phenyl group, a pyridyl group, an imidazolyl group, a furyl group or a thienyl group.Type: GrantFiled: June 7, 1995Date of Patent: May 26, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Fumio Suzuki, Akio Ishii, Hiromi Nonaka, Nobuo Kosaka, Shunji Ichikawa, Junichi Shimada
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Patent number: 5703085Abstract: The present invention relates to novel xanthine derivatives and pharmaceutically acceptable salts thereof, represented by Formula (I): ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 independently represent hydrogen, lower alkyl, lower alkenyl, or lower alkynyl, R.sup.4 represents lower alkyl, or substituted or unsubstituted aryl, R.sup.5 and R.sup.6 independently represent hydrogen, lower alkyl, and lower alkoxy, or R.sup.5 and R.sup.6 are combined together to represent --O--(CH.sub.2)p--O-- (p is an integer of 1 to 3), n represents 0, 1, or 2, and m represents 1 or 2.The compounds of the present invention have an adenosine A.sub.2 receptor antagonistic activity, and are useful for the treatment or prevention of various kinds of diseases caused by hyperergasia of adenosine A.sub.2 receptors (for example, Parkinson's disease, senile dementia, depression, asthma, and osteoporosis).Type: GrantFiled: October 20, 1995Date of Patent: December 30, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Fumio Suzuki, Nobuaki Koike, Junichi Shimada, Joji Nakamura, Shizuo Shiozaki, Shigeto Kitamura, Shunji Ichikawa, Hiroshi Kase, Hiromi Nonaka
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Patent number: 5587378Abstract: Methods for the treatment of Parkinson's disease comprising administering to a patient an agent which contains, as an active ingredient, a xanthine derivative or a pharmaceutically acceptable salt thereof. The xanthine derivative is represented by the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen, lower alkyl, lower alkenyl, or lower alkynyl; and R.sup.4 is cycloalkyl, --(CH.sub.2).sub.n --R.sup.5, wherein R.sup.5 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group; and n is an integer of 0 to 4, or ##STR2## wherein Y.sup.1 and Y.sup.2 represent independently hydrogen, halogen, or lower alkyl; and Z is substituted or unsubstituted aryl, ##STR3## wherein R.sup.6 is hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro, or amino; and m is an integer of 1 to 4, or a substituted or unsubstituted heterocyclic group; and X.sup.1 and X.sup.2 are independently O or S.Type: GrantFiled: May 23, 1995Date of Patent: December 24, 1996Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Fumio Suzuki, Junichi Shimada, Nobuaki Koike, Joji Nakamura, Shizuo Shiozaki, Shunji Ichikawa, Akio Ishii, Hiromi Nonaka
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Patent number: 5565460Abstract: The present invention relates to a therapeutic agent for Parkinson's disease containing as an active ingredient a polycyclic compound or a pharmaceutically acceptable salt thereof, the compound being represented by the following Formula (I): ##STR1## and A represents N or CR.sup.5 (in which R.sup.5 represents hydrogen, or substituted or unsubstituted lower alkyl), or represented by the following Formula (II): ##STR2## wherein Y, R.sup.6 and R.sup.8 are as defined herein and B and the adjacent two carbon atoms are combined to form a substituted or unsubstituted, partially saturated or unsaturated, monocyclic or bicyclic, carbocyclic or heterocyclic group.Type: GrantFiled: March 3, 1995Date of Patent: October 15, 1996Assignee: Kyowa Hakko Koygo Co., Ltd.Inventors: Fumio Suzuki, Junichi Shimada, Nobuaki Koike, Shunji Ichikawa, Joji Nakamura, Tomoyuki Kanda, Shigeto Kitamura
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Patent number: 5543415Abstract: The present invention relates to an antidepressant containing as an active ingredient a xanthine derivative or a pharmaceutically acceptable salt thereof, the xanthine derivative being represented by Formula (I) : ##STR1## in which R.sup.1, R.sup.2, and R.sup.3 represent independently hydrogen, lower alkyl, lower alkenyl;R.sup.4 represents cycloalkyl, --(CH.sub.2).sub.n --R.sup.5 (in which R.sup.5 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group; and n is an integer of 0 to 4), or ##STR2## (in which Y.sup.1 and Y.sup.2 represent independently hydrogen, halogen or lower alkyl; and Z represents substituted or unsubstituted aryl, ##STR3## (in which R.sup.6 represents hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro, or amino; and m represents an integer of 1 to 3), or a substituted or unsubstituted heterocyclic group);and X.sup.1 and X.sup.2 represent independently O or S.Type: GrantFiled: February 25, 1994Date of Patent: August 6, 1996Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Fumio Suzuki, Junichi Shimada, Akio Ishii, Joji Nakamura, Shunji Ichikawa, Shigeto Kitamura, Nobuaki Koike
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Patent number: 5484920Abstract: Agents for the treatment of Parkinson's disease contain, as an active ingredient, a xanthine derivative or a pharmaceutically acceptable salt thereof. The xanthine derivative is represented by the formula: ##STR1## in which R.sup.1, R.sup.2 are R.sup.3 are independently hydrogen, lower alkyl, lower alkenyl, or lower alkynyl; and R.sup.4 represents cycloalkyl, --(CH.sub.2).sub.n --R.sup.5 (in which R.sup.5 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group; and n is an integer of 0 to 4), or ##STR2## in which Y.sup.1 and Y.sup.2 represent independently hydrogen, halogen, or lower alkyl; and Z represents substituted or unsubstituted aryl, ##STR3## in which R.sup.6 represents hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro, or amino; and m represents an integer of 1 to 4, or a substituted or unsubstituted heterocyclic group; and X.sup.1 and X.sup.2 represent independently O or S.Type: GrantFiled: October 7, 1993Date of Patent: January 16, 1996Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Fumio Suzuki, Junichi Shimada, Nobuaki Koike, Joji Nakamura, Shizuo Shioazaki, Shunji Ichikawa, Akio Ishii, Hiromi Nonaka
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Patent number: 5319085Abstract: Quinoline derivatives represented by formula (I): ##STR1## wherein A-B-D represents --C(COO--Y).dbd.CH--C(OR).dbd. (wherein Y represents 8-methyl-8-azabicyclo[3.2.1]oct-3-yl group and R represents alkyl) or --C(OH).dbd.C(COX--Y)--CH.dbd. (wherein X represents --O-- or --NH--; and Y has the same meaning as described above), or a pharmaceutically acceptable salt thereof, possess potent 5HT.sub.3 antagonizing activity and are useful as antiemetic agents.Type: GrantFiled: April 16, 1993Date of Patent: June 7, 1994Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Fumio Suzuki, Hiroaki Hayashi, Yoshikazu Miwa, Takeshi Kuroda, Akio Ishii, Shunji Ichikawa, Ichiro Miki, Katsuichi Shuto
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Patent number: 5248684Abstract: There is disclosed a heterocyclic compound represented by general formula: ##STR1## wherein R.sup.1 represents hydrogen, lower alkyl or aryl; R.sup.2 represents hydrogen, hydroxyl or lower alkyl; A represents CH or N; X represents --O-- or --NH--; R.sup.3 represents hydrogen, hydroxyl or lower alkyl; R.sup.4 represents lower alkyl; represents 0 or 1, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 21, 1991Date of Patent: September 28, 1993Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Fumio Suzuki, Hiroaki Hayashi, Yoshikazu Miwa, Akio Ishii, Shunji Ichikawa, Ichiro Miki
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Patent number: 5155115Abstract: Disclosed is a thienopyridine derivative represented by formula (I): ##STR1## wherein one of A and B represents --S-- and the other represents --CH.dbd.; X represents --O-- or --NH--; R.sup.1 represents hydrogen or lower alkyl; R.sup.2 represents lower alkyl; and n represents 0 or 1; or a pharmaceutically acceptable salt thereof.The thienopyridine derivative is useful as anti-emetics and suppressant of migraine.Type: GrantFiled: March 4, 1992Date of Patent: October 13, 1992Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Fumio Suzuki, Yoshikazu Miwa, Hiroaki Hayashi, Akio Ishii, Shunji Ichikawa, Ichiro Miki
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Patent number: 5075301Abstract: A furan derivative and a pharmaceutically acceptable salt thereof having gastrointestinal enterokinetic activity which is expected to be used in a broad spectrum of diseases associated with gastrointestinal dyskinesia.Type: GrantFiled: August 14, 1990Date of Patent: December 24, 1991Assignee: Kyowa Hakko Kogyo, Co., Ltd.Inventors: Setsuya Sasho, Shunji Ichikawa, Hiromasa Kato, Hiroyuki Obase, Katsuichi Shuto, Yoshimasa Oiji
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Patent number: 5011824Abstract: A motilin preparation in the form of a rectal suppository containing motilin together with a pH controller capable of adjusting the pH value of the intrarectal fluid to 8.0 to 10.0, which is highly useful as a rectal suppository.Type: GrantFiled: November 13, 1989Date of Patent: April 30, 1991Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tomoaki Masada, Yasuhiko Ueno, Eiji Hayakawa, Hirotake Naganuma, Mitsuru Terajima, Tokuyuki Kuroda, Katsuichi Shuto, Shunji Ichikawa
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Patent number: 4962107Abstract: Compounds of the general formula ##STR1## wherein: X is halogen or trifluoromethyl;R.sub.1 is hydrogen, halogen or trifluoromethyl;R.sub.2 is hydrogen methyl or hydroxymethyl;R.sub.3 is hydrogen or lower alkyl; andY is methylene, methylene substituted with a lower alkyl or hydroxyl group, sulfinyl, sulfonyl, oxygen or sulfur, exhibit a cerebral protective effect and are applicable to the treatment of cerebral ischaemia and cerebral hypoxia.The compounds may be made by acylating a suitable piperidine or morpholine with the appropriate cinnamoyl chloride, and if necessary oxidizing the reaction product.Type: GrantFiled: March 10, 1989Date of Patent: October 9, 1990Assignees: Kyowa Hakko Kogyo Kabushiki Kaisha, Ihara Chemical Kogyo Kabushiki KaishaInventors: Joji Nakamura, Kazuhiro Kubo, Shunji Ichikawa, Hajime Takahashi, Keisuke Isozumi, Toyofumi Yamada
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Patent number: 4952576Abstract: Compounds having analgesic activity which have the formula ##STR1## wherein R.sub.1 -R.sub.6 represent hydrogen or a substituent and X and Y together represent inter alia as epoxyethylene, ethylene halohydrin, haloethylene or a --CH.dbd.CH-group.Type: GrantFiled: July 22, 1988Date of Patent: August 28, 1990Assignee: Kyowa Hakko Kogyo Kabushiki KaishaInventors: Toru Yasuzawa, Hiroshi Sano, Hirofumi Nakano, Shunji Ichikawa, Katsuichi Shuto
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Patent number: 4824842Abstract: Compounds of the general formula ##STR1## wherein: X is halogen or trifluoromethyl;R.sub.1 is hydrogen, halogen or trifluoromethyl;R.sub.2 is hydrogen, methyl or hydroxymethyl;R.sub.3 is hydrogen or lower alkyl; andY is methylene, methylene substituted with a lower alkyl or hydroxyl group, sulfinyl, sulfonyl, oxygen or sulfur, exhibit a cerebral protective effect and are applicable to the treatment of cerebral ischaemia and cerebral hypoxia.The compounds may be made by acylating a suitable piperidine or morpholine with the appropriate cinnamoyl chloride, and if necessary oxidizing the reaction product.Type: GrantFiled: February 13, 1986Date of Patent: April 25, 1989Assignee: Kyowa Hakko Kogyo Kabushiki KaishaInventors: Joji Nakamura, Kazuhiro Kubo, Shunji Ichikawa, Hajime Takahashi, Keisuke Isozumi, Toyofumi Yamada
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Patent number: 4588729Abstract: Offered is an anticonvulsive composition which comprises an effective amount of a dihydrouracil derivative represented by the formula: ##STR1## [wherein one of A and B is ##STR2## (wherein Y.sub.1, Y.sub.2 and Y.sub.3 are hydrogen atoms, lower alkyl groups, halogen atoms, nitro groups, amino groups, carboxyl groups, lower alkoxycarbonyl groups or trifluoromethyl groups), a naphthyl group or a diphenylmethyl group, and the other is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a cyclopentyl group, a cyclohexyl group or ##STR3## (wherein Z.sub.1, Z.sub.2 and Z.sub.3 are hydrogen atoms, lower alkyl groups, halogen atoms or trifluoromethyl groups), R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms or lower alkyl groups, and X is an oxygen atom or a sulfur atom] and at least one pharmaceutically acceptable carrier.Type: GrantFiled: May 16, 1985Date of Patent: May 13, 1986Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Masayuki Teranishi, Chikara Murakata, Ikuo Matsukuma, Katsuichi Shuto, Shunji Ichikawa