Abstract: A honeycomb panel laminate includes a sound absorbing face made of a foam, a sound absorbing layer, and a sound insulating face made of a foam. The sound absorbing layer is composed of a honeycomb material and a layer obtained by filling spaces with a hard foam material. The honeycomb material is bonded to the sound absorbing face by applying an adhesive to edges of the honeycomb material of the sound absorbing layer and pressing the edges against the sound absorbing face so that the edges bite into the foam. The sound insulating face is obtained by applying an adhesive allover a surface of the sound insulating face that makes contact with the honeycomb material and pressing opposite edges of cell walls of the honeycomb material against the sound insulating face so that the opposite edges bite into the surface, having the adhesive, of the foam.

Abstract: [Problem to be Solved] In a laminated material based on a honeycomb material, there has been such a problem that the bonding between a honeycomb material serving as a base and two face materials between which the honeycomb material is sandwiched requires bonding between planar members having great rigidity with a high degree of planar accuracy and honeycomb members that are linear and not completely flat, thus making it to obtain a great deal of bonding force. [Solution] A honeycomb panel laminate includes a sound absorbing face, a sound absorbing layer, and a sound insulating face. The sound absorbing face is made of a foam. The sound absorbing layer is composed of a honeycomb material and a layer obtained by filling spaces with a hard foam material.

Abstract: A bacterium belonging to the genus Streptomyces having an ability to produce reveromycin A or a synthetic intermediate thereof, the bacterium being modified so as to increase expression of revQ gene coding for the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence having an identity of not less than 80% to SEQ ID NO: 36 as compared with a parent strain, thereby the above-mentioned production ability is increased as compared with the parent strain.

Abstract: A bacterium belonging to the genus Streptomyces having an ability to produce reveromycin A or a synthetic intermediate thereof, the bacterium being modified so as to increase expression of revQ gene coding for the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence having an identity of not less than 80% to SEQ ID NO: 36 as compared with a parent strain, thereby the above-mentioned production ability is increased as compared with the parent strain.

Abstract: Bone metastasis and the efficacy of drugs in the treatment of malignant tumors such as breast cancer, prostatic cancer and lung cancer that cause the bone metastasis are diagnosed using a marker that reflects the activity of osteoblasts and a marker that reflects the action of osteoclasts.

Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

Abstract: A knocking control apparatus for a variable cylinder internal combustion engine avoids erroneous determination of knocking during a fault in a cylinder pausing mechanism to appropriately control knocking associated with the ignition timing, thereby preventing engine stall and reducing a deterioration in a catalyst. The variable cylinder internal combustion engine can be switched between a full cylinder operation mode in which all of a plurality of cylinders are operated, and a partial cylinder operation mode in which part of the plurality of cylinders is paused by a cylinder pausing mechanism.

Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

Abstract: A control apparatus, a control method, and an engine control unit for a variable cylinder internal combustion engine are provided for appropriately performing any of an idling rotational speed control, a deceleration fuel-cut control, and an auxiliary machinery driving control irrespective of whether or not a cylinder pausing mechanism fails. The control apparatus for the variable cylinder internal combustion engine switchably operated in a full cylinder operation mode and a partial cylinder operation mode comprises an ECU. The ECU determines whether or not the cylinder pause mechanism fails, and sets a target idling rotational speed for use in the idling rotational speed control to a normal operation value when the cylinder pausing mechanism is normal and to a faulty operation value higher than the normal operation value when the cylinder pausing mechanism is faulty.

Abstract: A knocking control apparatus for a variable cylinder internal combustion engine avoids erroneous determination of knocking during a fault in a cylinder pausing mechanism to appropriately control knocking associated with the ignition timing, thereby preventing engine stall and reducing a deterioration in a catalyst. The variable cylinder internal combustion engine can be switched between a full cylinder operation mode in which all of a plurality of cylinders are operated, and a partial cylinder operation mode in which part of the plurality of cylinders is paused by a cylinder pausing mechanism.

Abstract: A control apparatus, a control method, and an engine control unit for a variable cylinder internal combustion engine are provided for appropriately performing any of an idling rotational speed control, a deceleration fuel-cut control, and an auxiliary machinery driving control irrespective of whether or not a cylinder pausing mechanism fails. The control apparatus for the variable cylinder internal combustion engine switchably operated in a full cylinder operation mode and a partial cylinder operation mode comprises an ECU. The ECU determines whether or not the cylinder pause mechanism fails, and sets a target idling rotational speed for use in the idling rotational speed control to a normal operation value when the cylinder pausing mechanism is normal and to a faulty operation value higher than the normal operation value when the cylinder pausing mechanism is faulty.

Abstract: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

Abstract: A variable valve-timing engine includes a VTC for adjusting a relative phase angle of an exhaust cam for opening and closing an exhaust valve and an intake cam for opening and closing an intake valve; an oil pressure controlling unit for operating the VTC; a deterioration detecting unit for detecting the deterioration of hydraulic fluid in the oil pressure controlling unit; a correcting unit for correcting the oil pressure of hydraulic fluid of the oil pressure controlling unit based on a detected value by the deterioration detection unit, and a deterioration indicating unit for indicating a replacement of the hydraulic fluid based on the detected value of the deterioration detecting unit, so that the user can be advised of a required oil replacement.