Abstract: There is provision of a substrate support assembly including an edge ring, a substrate support, and a thermal conductivity adjuster. The substrate support has a central portion that supports a substrate, and an outer peripheral portion that supports the edge ring arranged around the substrate. The thermal conductivity adjuster is in contact with a part of the edge ring in a circumferential direction, and a thermal conductivity of the thermal conductivity adjuster is different from a thermal conductivity of the edge ring.

Abstract: In order to perform overheating protection of a controller for water-heating heaters 3A and 3B for in-vehicle heating, an energization circuit for a heater 3 (3A, 3B) includes IGBTs 11 and 12 as switching devices that are disposed therein to be in series with the heater 3, and a first temperature sensor (first thermistor) 21 which measures temperature of these IGBTs 11, 12. A comparator 25 is provided to transmit a signal when the temperature of the IGBTs 11, 12 is equal to or greater than a predetermined temperature. Then, the IGBTs 11, 12 can be forcibly turned OFF via the IGBT driver 13 in response to a signal from the comparator 25 without a microprocessor 14 intervening therebetween.

Abstract: In order to perform overheating protection of a controller for water-heating heaters 3A and 38 for in-vehicle heating, an energization circuit for a heater 3 (3A, 38) includes IGBTs 11 and 12 as switching devices that are disposed therein to be in series with the heater 3, and a first temperature sensor (first thermistor) 21 which measures temperature of these IGBTs 11,12. A comparator 25 is provided to transmit a signal when the temperature of the IGBTs 11,12 is equal to or greater than a predetermined temperature. Then, the IGBTs 1112 can be forcibly turned OFF via the IGBT driver 13 in response to a signal from the comparator 25 without a microprocessor 14 intervening therebetween.

Abstract: (S)-1-(4-Chloro-5-isoquinolinesulfonyl)-3-(methylamino)pyrrolidine monohydrochloride and a crystal thereof, and a crystal of the aforementioned monohydrochloride having a major peak or peaks at one or more positions selected from the group consisting of positions where 2?s are about 13.9°, 21.5°, 21.7°, 22.4°, 22.8°, 24.5° and 35.0° in a powder X-ray diffraction spectrum, which have excellent properties as active ingredient of a medicament for prophylactic and/or therapeutic treatment of glaucoma and the like.

Abstract: The present invention relates to a compound represented by the following formula (1): wherein D1, A1, D2, R1, D3, and R2 each have the same meaning as defined in the present specification or a salt thereof. The compound represented by the formula (1) or a salt thereof has an IKK? inhibiting activity and the like and is useful for the prevention and/or treatment of IKK?-associated diseases or symptoms and the like.

Abstract: (S)-1-(4-Chloro-5-isoquinolinesulfonyl)-3-(methylamino)pyrrolidine monohydrochloride and a crystal thereof, and a crystal of the aforementioned monohydrochloride having a major peak or peaks at one or more positions selected from the group consisting of positions where 2?s are about 13.9°, 21.5°, 21.7°, 22.4°, 22.8°, 24.5° and 35.0° in a powder X-ray diffraction spectrum, which have excellent properties as active ingredient of a medicament for prophylactic and/or therapeutic treatment of glaucoma and the like.

Abstract: (S)-1-(4-Chloro-5-isoquinolinesulfonyl)-3-(methylamino)pyrrolidine monohydrochloride and a crystal thereof, and a crystal of the aforementioned monohydrochloride having a major peak or peaks at one or more positions selected from the group consisting of positions where 2?s are about 13.9°, 21.5°, 21.7°, 22.4°, 22.8°, 24.5° and 35.0° in a powder X-ray diffraction spectrum, which have excellent properties as active ingredient of a medicament for prophylactic and/or therapeutic treatment of glaucoma and the like.

Abstract: The present invention relates to a compound represented by the following formula (1): wherein D1, A1, D2, R1, D3, and R2 each have the same meaning as defined in the present specification or a salt thereof. The compound represented by the formula (1) or a salt thereof has an IKK? inhibiting activity and the like and is useful for the prevention and/or treatment of IKK?-associated diseases or symptoms and the like.

Abstract: (S)-1-(4-Chloro-5-isoquinolinesulfonyl)-3-(methylamino)pyrrolidine monohydrochloride and a crystal thereof, and a crystal of the aforementioned monohydrochloride having a major peak or peaks at one or more positions selected from the group consisting of positions where 2?s are about 13.9°, 21.5°, 21.7°, 22.4°, 22.8°, 24.5° and 35.0° in a powder X-ray diffraction spectrum, which have excellent properties as active ingredient of a medicament for prophylactic and/or therapeutic treatment of glaucoma and the like.