Patents by Inventor Shuntaro Takano
Shuntaro Takano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Immunomodulator, cell adhesion inhibitor, and agent for treating, and preventing autoimmune diseases
Patent number: 6166068Abstract: Autoimmune diseases, cell adhesion inhibition and immunomodulation are treated or effected by a method, comprising, treating a patient with a therapeutically effective amount of a 4H-1-benzopyran-4-one compound represented by the following formula or a salt thereof: ##STR1## wherein R.sup.1 is an unsubstituted or halogen-substituted alkyl, alkenyl or aryl group; R.sup.2 is a hydrogen atom or an alkyl or acyl group; R.sup.3 is a hydrogen or halogen atom or a cyano, azido, carboxyl, hydroxyl, formyl or alkoxycarbonyl group or a substituted or unsubstituted alkyl, alkoxy, phenoxy, cycloalkyl, carbamoyl, amino or phenyl group; R.sup.4 is a hydrogen or halogen atom, a nitro, cyano, carboxyl, acyl, hydroxyl or alkoxycarbonyl group, or a substituted or unsubstituted alkyl, alkoxy, alkylthio, phenylthio, alkynyl, alkenyl, sulfamoyl, alkanesulfonyl, alkanesulfonyl, amidino, phenyl or heterocyclic group or a group of the formula ##STR2## where R.sup.Type: GrantFiled: July 2, 1999Date of Patent: December 26, 2000Assignee: Toyama Chemical Co., Ltd.Inventors: Keiichi Tanaka, Shinji Makino, Ichiro Oshio, Tomoya Shimotori, Yukihiko Aikawa, Takihiro Inaba, Chosaku Yoshida, Shuntaro Takano, Yoichi Taniguchi -
Patent number: 5922755Abstract: A 4H-1-benzopyran-4-one derivative of the general formura ?1!, ##STR1## or a salt thereof exerts excellent effects on immunomodulation and cell adhesion inhibition, and is further expected to have the effect of relieving autoimmune diseases at a level comparable to that of steroids. Thus, the compound of the general formula ?1! is useful in the teatment and prevention of autoimmune diseases fundamentally caused by immunopathy or unusually accelerated cell adhesion, for example, chronic rheumatoid arthritis, systemic lupus erythematosus, scleroderma, mixed connective tissue disease,polyarteritis nodosa, polymyositis/dermatomyositis, Sjogren's syndrome, Behcet's disease, multiple sclerosis, autoimmune diabetes, Hashimoto's disease, psoriasis, primary myxedema, pernicious anemia, serious adynamia, ulcerative colitis, chronic active hepatitis, autoimmune hemolytic anemia idiopathic thrombocytopenic purpura and the like.Type: GrantFiled: May 6, 1996Date of Patent: July 13, 1999Assignee: Toyama Chemical Co., Ltd.Inventors: Keiichi Tanaka, Shinji Makino, Ichiro Oshio, Tomoya Shimotori, Yukihiko Aikawa, Takihiro Inaba, Chosaku Yoshida, Shuntaro Takano, Yoichi Taniguchi
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Patent number: 5236950Abstract: This invention relates to a hair-restorer comprising, as an active ingredient, (a) an acyclic branched higher aliphatic hydrocarbon of 20 carbon atoms which may be substituted with hydroxyl group or acyloxy group, or (b) an acyclic branched carboxylic acid of 20 carbon atoms or its derivative and to a process for hair growth.Type: GrantFiled: February 17, 1989Date of Patent: August 17, 1993Assignee: Toyama Chemical Co., Ltd.Inventors: Hajime Aoyama, Satoshi Ono, Osamu Oohashi, Hirokazu Narita, Shuntaro Takano
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Patent number: 4954518Abstract: This invention relates to a 4H-1-benzopyran-4-one derivative represented by the formula: ##STR1## or a salt thereof, a process for producing the same and a pharmaceutical composition comprising the same as active ingredient.Type: GrantFiled: October 7, 1988Date of Patent: September 4, 1990Assignee: Toyama Chemical Company, Ltd.Inventors: Shuntaro Takano, Chosaku Yoshida, Takihiro Inaba, Keiichi Tanaka, Ryuko Takeno, Hideyoshi Nagaki, Tomoya Shimotori, Shinji Makino
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Patent number: 4851535Abstract: This invention relates to a process for industrially producing a 1-substituted aryl-1,4-dihydro-4-oxonaphthyridine derivative and a salt thereof which are useful as an antibacterial agent, and also to intermediates therefor and processes for producing the intermediates.Type: GrantFiled: June 29, 1987Date of Patent: July 25, 1989Assignee: Toyama Chemical Co., Ltd.Inventors: Yozo Todo, Tetsuo Yamafuji, Katsuyuki Nagumo, Isao Kitayama, Hideyoshi Nagaki, Mikako Miyajima, Yoshinori Konishi, Hirokazu Narita, Shuntaro Takano, Isamu Saikawa
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Patent number: 4736026Abstract: The invention relates to a process for producing a cephalosporin of the formula ##STR1## by reacting the compound ##STR2## with the compound ##STR3## in the presence of boron trifluoride or a complex thereof.Type: GrantFiled: June 24, 1986Date of Patent: April 5, 1988Assignee: Toyama Chemical Co., Ltd.Inventors: Hiroyuki Imaizumi, Takihiro Inaba, Seishi Morita, Ryuko Takeno, Yoshiharu Murotani, Hirohiko Fukuda, Junichi Yoshida, Kiyoshi Tanaka, Shuntaro Takano, Isamu Saikawa
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Patent number: 4704459Abstract: This invention relates to a process for industrially producing a 1-substituted aryl-1,4-dihydro-4-oxonaphthyridine derivative and a salt thereof which are useful as an antibacterial agent, and also to intermediates therefor and processes for producing the intermediates.Type: GrantFiled: January 17, 1986Date of Patent: November 3, 1987Assignee: Toyama Chemical Co., Ltd.Inventors: Yozo Todo, Tetsuo Yamafuji, Katsuyuki Nagumo, Isao Kitayama, Hideyoshi Nagaki, Mikako Miyajima, Yoshinori Konishi, Hirokazu Narita, Shuntaro Takano, Isamu Saikawa
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Patent number: 4656287Abstract: This invention relates to a novel aminothiazole intermediate for production of a cephalosporin of antibiotic activity.Type: GrantFiled: July 11, 1985Date of Patent: April 7, 1987Assignee: Toyoma Chemical Co., Ltd.Inventors: Hiroyuki Imaizumi, Takihiro Inaba, Seishi Morita, Ryuko Takeno, Yoshiharu Murotani, Hirohiko Fukuda, Junichi Yoshida, Kiyoshi Tanaka, Shuntaro Takano, Isamu Saikawa
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Patent number: 4410522Abstract: Novel penicillins and cephalosporins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group in molecule. These compounds are valuable antibacterial compounds for use in mammals including man. This disclosure relates to such compounds and a process for the preparation thereof.Type: GrantFiled: October 12, 1977Date of Patent: October 18, 1983Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Chosaku Yoshida, Okuta Takashima, Kaishu Momonoi, Seietsu Kuroda, Miwako Komatsu, Takashi Yasuda, Yutaka Kodama
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Patent number: 4395412Abstract: A 7.alpha.-methoxycephalosporin represented by the general formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or a carboxyl-protecting group; R.sup.2 represents an organic group linked to the carbon atom through an oxygen or sulfur atom; R.sup.3 represents a lower alkyl group; n is 0, 1 or 2; A represents a hydrogen atom or a substituted or unsubstituted alkyl group; and B represents a substituted or unsubstituted alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl or heterocyclic group, and a salt thereof. These compounds have a broad antibacterial spectrum, high resistance to .beta.-lactamase produced from bacteria, and an effective antibacterial activity against clinical isolates of bacteria.Type: GrantFiled: December 31, 1980Date of Patent: July 26, 1983Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Hiroyuki Imaizumi, Isamu Takakura, Hirokazu Ochiai, Takashi Yasuda, Hideo Taki, Masaru Tai, Yutaka Kodama
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Patent number: 4385178Abstract: This disclosure relates to a novel process for producing 7-(substituted)amino-3-substituted thiomethyl cephem carboxylic acids which are intermediate products of cephalosporins being valuable antibacterial compounds for use in mammals including man.Type: GrantFiled: December 17, 1981Date of Patent: May 24, 1983Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Kaishu Momonoi, Isamu Takakura, Seietsu Kuroda, Kiyoshi Tanaka, Kenshin Hayashi, Bunei Nagahashi, Chiaki Kutani
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Patent number: 4379152Abstract: Novel penicillins and cephalosporins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group in molecule. These compounds are valuable antibacterial compounds for use in mammals including man. This disclosure relates to such compounds and a process for the preparation thereof.Type: GrantFiled: May 17, 1979Date of Patent: April 5, 1983Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Chosaku Yoshida, Okuta Takashima, Kaishu Momonoi, Seietsu Kuroda, Miwako Komatsu, Takashi Yasuda, Yutaka Kodama
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Patent number: 4327097Abstract: Novel penicillins and cephalosporins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group have been prepared. These compounds are valuable anti-bacterial compounds for use in mammals including man. A process for the preparation of the compounds has also been discovered.Type: GrantFiled: June 12, 1979Date of Patent: April 27, 1982Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Chosaku Yoshida, Okuta Takashima, Kaishu Momonoi, Seietsu Kuroda, Miwako Komatsu, Takashi Yasuda, Yutaka Kodama
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Patent number: 4321265Abstract: A 7.alpha.-methoxycephalosporin represented by the general formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or a carboxyl-protecting group; R.sup.2 represents an organic group linked to the carbon atom through an oxygen or sulfur atom; R.sup.3 represents a lower alkyl group; n is 0, 1 or 2; A represents a hydrogen atom or a substituted or unsubstituted alkyl group; and B represents a substituted or unsubstituted alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl or heterocyclic group, and a salt thereof. These compounds have a broad antibacterial spectrum, high resistance to .beta.-lactamase produced from bacteria, and an effective antibacterial activity against clinical isolates of bacteria.Type: GrantFiled: February 1, 1980Date of Patent: March 23, 1982Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Hiroyuki Imaizumi, Isamu Takakura, Hirokazu Ochiai, Takashi Yasuda, Hideo Taki, Masaru Tai, Yutaka Kodama
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Patent number: 4317907Abstract: This disclosure relates to a novel process for producing 7-(substituted)amino-3-substituted thiomethyl cephem carboxylic acids which are intermediate products of cephalosporins being valuable antibacterial compounds for use in mammals including man.Type: GrantFiled: February 2, 1978Date of Patent: March 2, 1982Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Kaishu Momonoi, Isamu Takakura, Seietsu Kuroda, Kiyoshi Tanaka, Kenshin Hayashi, Bunei Nagahashi, Chiaki Kutani
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Patent number: 4312986Abstract: This disclosure relates to a novel process for producing 7-(substituted)-amino-3-substituted thiomethyl-.DELTA..sup.3 -cephem-4-carboxylic acids which are intermediate products of cephalosporins being valuable antibacterial compounds for use in mammals including man.Type: GrantFiled: July 5, 1979Date of Patent: January 26, 1982Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Kaishu Momonoi, Isamu Takakura, Seietsu Kuroda, Kiyoshi Tanaka, Kenshin Hayashi, Bunei Nagahashi, Chiaki Kutani
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Patent number: 4304909Abstract: The N,N-dimethylacetamide adduct of 7-[D(-)-.alpha.-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-.alpha.-(4-hyd roxyphenyl)acetamido]-3-[5-(1-methyl-1,2,3,4-tetrazolyl)thiomethyl]-.DELTA. .sup.3 -cephem-4-carboxylic acid, a process for the production thereof, and a process for producing said acid and a pharmaceutically acceptable salt thereof through said adduct.Type: GrantFiled: August 24, 1979Date of Patent: December 8, 1981Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Kaishu Momonoi, Isamu Takakura, Chiaki Kutani, Kiyoshi Tanaka, Kenshin Hayashi
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Patent number: 4263292Abstract: A 7.alpha.-methoxycephalosporin represented by the general formula and a salt thereof: ##STR1## wherein R.sup.1 represents a hydrogen atom or a carboxyl-protecting group; R.sup.2 represents an organic group linked to the carbon atoms through an oxygen or sulfur atom; R.sup.3 represents a lower alkyl group; n is 0, 1 or 2; A represents a hydrogen atom or a substituted or unsubstituted alkyl group; and B represents a substituted or unsubstituted alkyl group. These compounds have a broad antibacterial spectrum and high resistance to .beta.-lactamase produced from bacteria, and are well absorbed in a living body.Type: GrantFiled: October 4, 1979Date of Patent: April 21, 1981Assignee: Toyama Chemical Co., Ltd.Inventors: Isamu Saikawa, Shuntaro Takano, Hiroyuki Imaizumi, Isamu Takakura, Hirokazu Ochiai, Takashi Yasuda, Hideo Taki, Masaru Tai, Yutaka Kodama
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Patent number: 4237280Abstract: The N,N-dimethylacetamide adduct of 7-[D(-)-.alpha.-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-.alpha.-(4-hyd roxyphenyl)acetamido]-3-[5-(1-methyl-1,2,3,4-tetrazolyl)thiomethyl]-.DELTA. .sup.3 -cephem-4-carboxylic acid, a process for the production thereof, and a process for producing said acid and a pharmaceutically acceptable salt thereof through said adduct.Type: GrantFiled: September 25, 1978Date of Patent: December 2, 1980Assignee: Toyama Chemical Company, LimitedInventors: Isamu Saikawa, Shuntaro Takano, Kaishu Momonoi, Isamu Takakura, Chiaki Kutani, Kiyoshi Tanaka, Kenshin Hayashi
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Patent number: 4219554Abstract: Novel penicillins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group have been prepared. These compounds are valuable antibacterial compounds for use in mammals including man. A process for the preparation of the compounds has also been discovered.Type: GrantFiled: June 15, 1978Date of Patent: August 26, 1980Assignee: Toyama Chemical Company, LimitedInventors: Isamu Saikawa, Shuntaro Takano, Chosaku Yoshida, Okuta Takashima, Kaishu Momonoi, Seietsu Kuroda, Miwako Komatsu, Takashi Yasuda, Yutaka Kodama