Patents by Inventor Shunwu Fan

Shunwu Fan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation method of gradient mineralized cancellous bone matrix material
    Patent number: 11684696
    Abstract: A gradient mineralized cancellous bone matrix material and a preparation method thereof are provided, and the preparation method includes: processing naturally-derived bone tissue with an immunogenicity removal treatment for decellularization, and processing an obtained decellularzed bone with a gradient demineralization treatment to obtain the gradient mineralized cancellous bone matrix material. The present invention expands a porosity of the bone matrix material and a collagen exposure degree on a surface thereof, which effectively releases growth factors and improves adhesion of the material to the cells, so as to up-regulate genes and proteins related to cell regeneration.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: June 27, 2023
    Assignees: SIR RUN RUN SHAW HOSPITAL ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE, ZHEJIANG DISAI BIOTECHNOLOGY CO., LTD
    Inventors: Xianfeng Lin, Shijie Liu, Yiyun Wang, Yazhi Lu, Shunwu Fan
  • Nano composite material aiming at acidic sealing zone in osteoclasts and preparation method thereof
    Publication number: 20220313609
    Abstract: A nano composite material aiming at an acidic sealing zone in osteoclasts and a preparation method thereof are provided. The nano composite material aiming at the acidic sealing zone in the osteoclasts includes a nano material, bone-targeting molecules, and a compound able to react with the acidic sealing zone in the osteoclasts, wherein: after being modified by the bone-targeting molecules, the nano material is loaded with the compound able to react with the acidic sealing zone in the osteoclasts. Through accurate mature osteoclast targeting and chemically regulated biocascade effects, the osteoclasts are inhibited, which provides a new idea and a new tool for drug therapy of abnormal osteoclast activation.
    Type: Application
    Filed: April 10, 2020
    Publication date: October 6, 2022
    Inventors: Xianfeng Lin, Chenhui Gu, Qingqing Wang, Shunwu Fan
  • Preparation method of gradient mineralized cancellous bone matrix material
    Publication number: 20210121605
    Abstract: A gradient mineralized cancellous bone matrix material and a preparation method thereof are provided, and the preparation method includes: processing naturally-derived bone tissue with an immunogenicity removal treatment for decellularization, and processing an obtained decellularzed bone with a gradient demineralization treatment to obtain the gradient mineralized cancellous bone matrix material. The present invention expands a porosity of the bone matrix material and a collagen exposure degree on a surface thereof, which effectively releases growth factors and improves adhesion of the material to the cells, so as to up-regulate genes and proteins related to cell regeneration.
    Type: Application
    Filed: March 12, 2019
    Publication date: April 29, 2021
    Inventors: Xianfeng Lin, Shijie Liu, Yiyun Wang, Yazhi LU, Shunwu Fan