Patents by Inventor Shunzo Fukatsu
Shunzo Fukatsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5527781Abstract: As new compounds are now synthetized 5-deoxy-5,5-difluoro derivatives of aminoglycosidic antibiotics of neamine, kanamycin A-series, kanamycin B-series, gentamicin-series and seldomycin-series. Further, the 1-N-(.alpha.-hydroxy-.omega.-aminoalkanoyl) derivatives are synthetized from 5-deoxy-5,5-difluorokanamycins A and B, as well as their analogues now obtained. The 5-deoxy-5,5-difluoro derivatives of the aminoglycosidic antibiotics now provided according to this invention have such antibacterial activities enhanced much more than or equal to those of the respectively corresponding parent aminoglycosidic antibiotics, while these 5-deoxy-5,5-difluoro derivatives exhibit values of the 50% lethal dosage (LD.sub.50) which are improved remarkably better when they are intravenously administered to mice, so that they have remarkedly reduced toxicities to mammals.Type: GrantFiled: April 21, 1993Date of Patent: June 18, 1996Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Tomio Takeuchi, Sumio Umezawa, Tsutomu Tsuchiya, Tetsuo Shitara, Shunzo Fukatsu, Eijiro Umemura
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Patent number: 5011019Abstract: A container for packaging a medicine, which comprises a plastic sheet for accommodating a medicine therein, the plastic sheet having an olefin layer into which a deodorizing agent is mixed to remove foul odor emitted from the medicine therein.Type: GrantFiled: November 20, 1989Date of Patent: April 30, 1991Assignee: Kabushiki Kaisha Hosokawa YokoInventors: Toyomi Satoh, Kiyonori Hosoi, Katsuji Kinoshita, Shinjiro Murata, Shunzo Fukatsu, Tooru Ichikawa
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Patent number: 4870207Abstract: Known compound, optically active arphamenine A can now be synthesized in an optically active pure form and in a favorable yield by a new process comprising consecutive steps with starting from L-arginine, wherein racemization of intermediate reaction products can be minimized.Type: GrantFiled: July 30, 1987Date of Patent: September 26, 1989Assignee: Zaiden Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, deceased, Takaaki Aoyagi, Kuniaki Tatsuta, Takeshi Nakamura, Shunzo Fukatsu
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Patent number: 4839350Abstract: A class of new caphalosporin compounds (syn-isomer) is now provided, which is useful as antibacterial agent and is represented by the general formula (I) ##STR1## wherein R.sup.1 is an amino group or a protected amino group; R.sup.2 is a lower alkyl group, a carboxymethyl group or a protected carboxymethyl group; R.sup.3 is a hydrogen atom, a salt-forming cation or a carboxyl-protecting group; A is an unsubstituted or substituted phenyl group, an unsubstituted or substituted furyl group, an unsubstituted or substituted thiazolyl group or an unsubstituted or substituted 3-lower-alkylthiazolio group, and a pharmaceutically acceptable salt or ester thereof.Type: GrantFiled: April 7, 1987Date of Patent: June 13, 1989Assignees: Meiji Seika Kaisha, Ltd., Susumu MitsuhashiInventors: Kunio Atsumi, Kenji Sakagami, Yuichi Yamamoto, Takashi Yoshida, Ken Nishihata, Shinichi Kondo, Shunzo Fukatsu
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Patent number: 4791197Abstract: A new cephalosporin compound is now provided, which is useful as antibacterial agent and is represented by the general formula (I) ##STR1## wherein R.sup.1 is an amino group or a protected amino group; R.sup.2 is a hydrogen atom, a salt-forming cation or a carboxyl-protecting group; R.sup.3 is a hydrogen atom, a halogen atom, a lower alkylthio group, a lower alkoxyl group, a vinyl group or a group of the formula: --CH.sub.2 Y where Y is a hydrogen atom, a halogen atom, an acyloxy group, an unsubstituted or substituted heterocyclic thio group or an unsubstituted or substituted pyridinio group, and a pharmaceutically acceptable salt or ester thereof.Type: GrantFiled: July 2, 1985Date of Patent: December 13, 1988Inventors: Kenji Sakagami, Kunio Atsumi, Ken Nishihata, Takashi Yoshida, Shunzo Fukatsu
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Patent number: 4785090Abstract: This is a class of antibacterial compounds of the formula: ##STR1## wherein Y is straight or branched alkyl or alkenyl chain, cycloalkanomethyl of 3-6 carbon atoms, each group being optionally substituted by halogen, or a group ##STR2## wherein n is 0 or an integer of 1-3, A is a group --COR.sup.3 wherein R.sup.3 is hydroxy, a group ##STR3## wherein R.sup.4 and R.sup.5, which may be the same or different, are hydrogen or alkyl of 1-5 carbon atoms, a group ##STR4## or a 5- or 6-membered heterocyclic group containing nitrogen and/or sulfur, and R.sup.1 and R.sup.2, which may be the same or different, are hydrogen, alkyl of 1-5 carbon atoms, or R.sup.1 and R.sup.2 may be combined together to form cycloalkylidene of 3-5 carbon atoms, and Z is a group of the formula: ##STR5## wherein m is 0 or an integer of 3-5, R.sup.6 is hydrogen or alkyl of 1-3 carbon atoms, and R.sup.7, when m is an integer of 3-5, is alkyl of 1-5 carbon atoms, alkenyl, cyclopropyl, a group --(CH.sub.2).sub.Type: GrantFiled: February 21, 1985Date of Patent: November 15, 1988Assignee: Meiji Seika Kaisha, Ltd.Inventors: Takashi Tsuruoka, Seiji Shibahara, Katsuyoshi Iwamatsu, Tsuneo Okonogi, Satoru Nakabayashi, Yasushi Murai, Hiroko Ogino, Kiyoaki Katano, Takashi Yoshida, Shigeharu Inoue, Shunzo Fukatsu, Shinichi Kondo
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Patent number: 4783415Abstract: A DNA segment of a gene coding for a signal peptide is disclosed the segment is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host by incorporation in the vector DNA. The segment comprises a DNA having a base sequence coding for the peptide having the amino acid sequence from X to Y in the annexed FIG. 1.A vector plasmid to be used for transformation of bacteria belonging to the genus Streptomyces is also disclosed. The plasmid comprises a DNA segment with a base sequence coding for an extra-cellular .alpha.-amylase derived from Streptomyces hygroscopicus SF-1084 strain or a mutant thereof the DNA segment incorporated into a vector plasmid is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host and also having a DNA segment necessary for expression of the gene information of the DNA segment.Type: GrantFiled: March 27, 1985Date of Patent: November 8, 1988Assignee: Meiji Seika Kabushiki KaishaInventors: Shigeru Hoshiko, Osamu Makabe, Shunzo Fukatsu, Kozo Nagaoka
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3-[N-(mercaptoacyl)]amino-4-arylbutanoic acid derivatives and an analgesic agent comprising the same
Patent number: 4719231Abstract: New 3-[N-(mercaptoacyl)]amino-4-arylbutanoic acid derivatives are now provided, which exhibit analgesic activity and are effective to enhance the analgesia induced by a known analgesic compound, ]D-ala.sup.2,met.sup.5 ]-enkephalin (DAME).Type: GrantFiled: May 20, 1985Date of Patent: January 12, 1988Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Tomio Takeuchi, Takaaki Aoyagi, Mitsugu Hachisu, Masao Hirayama, Shinjiro Murata, Shunzo Fukatsu -
Patent number: 4687769Abstract: A class of new cephem compounds is now provided, which is useful as antibacterial agent and is represented by the general formula (I) ##STR1## wherein R.sup.1 is methyl group or carboxymethyl group and R.sup.2 is carboxyl group or a protected carboxyl group, and a pharmaceutically acceptable salt or ester thereof.Type: GrantFiled: December 16, 1985Date of Patent: August 18, 1987Assignee: Meiji Seika Kaisha, Ltd.Inventors: Yuichi Yamamoto, Takashi Yoshida, Shunzo Fukatsu, Toshiyasu Ishimaru
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Patent number: 4645769Abstract: The subject invention includes a 1-oxa-1-dethia-cephalosporin compound represented by the general formula (1) ##STR1## wherein R.sup.1 is a group of the formula: ##STR2## where R.sup.5 is a methyl group, an ethyl group, a carboxymethyl group or a 2-carboxy isopropyl group, or R.sup.1 is a group of the formula: ##STR3## where R.sup.6 is a hydrogen atom, a 4-ethyl-2,3-dioxopiperazine-1-yl group, a 3,4-dihydroxy phenyl group or a 5- and 6-membered heterocyclic radical having 2 ring nitrogens as the sole hetero substituent in the ring and having at least one hetero group on the carbon adjacent to the ring nitrogens.Type: GrantFiled: March 1, 1985Date of Patent: February 24, 1987Assignee: Merck & Co., Inc.Inventors: Seiji Shibahara, Tsuneo Okonogy, Yasushi Murai, Shunzo Fukatsu, Taro Niida, Burton G. Christensen, Tadashi Wakazawa
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Patent number: 4556513Abstract: Disclosed is a process for preparing antibiotic 1-oxadethiacephalosporins via diazo-species I: ##STR1## wherein: A is acyl; R.sup.1 is H or OCH.sub.3 ; and R.sup.2 is a protecting group.Type: GrantFiled: August 15, 1984Date of Patent: December 3, 1985Assignee: Meiji Seika Kaisha, Ltd.Inventors: Seiji Shibahara, Tsuneo Okonogi, Yasushi Murai, Shunzo Fukatsu, Taro Niida, Tadashi Wakazawa
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Patent number: 4547492Abstract: 1-N-(L-3-amino-2-hydroxypropionyl)-2',-3'-dideoxykanamycin A and 1-N-(L-4-amino-2-hydroxybutyryl)-2',3'-dideoxykanamycin A are now provided which each is a new compound useful as antibacterial agent. The new compounds each is produced by acylating the 1-amino group of 2',3'-dideoxykanamycin A with L-3-amino-2-hydroxypropionic or L-4-amino-2-hydroxybutyric acid.Type: GrantFiled: August 10, 1984Date of Patent: October 15, 1985Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Sumio Umezawa, Tsutomu Tsuchiya, Toshio Yoneta, Shunzo Fukatsu
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Patent number: 4534898Abstract: This invention relates to 1-oxa-1-dethia-cephalosporins which are useful as anti-biotics.Type: GrantFiled: July 20, 1983Date of Patent: August 13, 1985Assignee: Merck & Co., Inc.Inventors: Seiji Shibahara, Tsuneo Okonogi, Yasushi Murai, Shunzo Fukatsu, Tadashi Wakazawa, Taro Niida, Burton G. Christensen
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Patent number: 4510102Abstract: Disclosed is a novel process for preparing [(3-amino-3-carboxy)-propyl-1]phosphinic acid derivatives, comprising reacting an alkylalkylphosphonyl halide with a vinylmagnesium halide to form a vinylphosphinic acid derivative, and reacting the vinylphosphinic acid derivative with a Shiff's base to form the aimed product. Also disclosed is a novel intermediate compound formed during the course of the above process, which compound has the general formula: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in the specification).Type: GrantFiled: January 18, 1983Date of Patent: April 9, 1985Assignee: Meiji Seika Kaisha Ltd.Inventors: Nobuto Minowa, Shunzo Fukatsu, Taro Niida, Sadaaki Mase
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Patent number: 4499027Abstract: Disclosed is a novel process for optically active [(3-amino-3-carboxy)propyl-1]phosphinic acid derivatives, which comprises reacting a Shiff's base with a derivative of vinylphosphinate in the presence of a base, and subjecting the resulting compound to hydrolysis to form the optically active [(3-amino-3-carboxy)propyl-1]phosphinic acid derivatives as either [L-(3-amino-3-carboxy)propyl-1]phosphinic acid derivatives or [D-(3-amino-3-carboxy)propyl-1]phosphinic acid derivatives.Type: GrantFiled: May 18, 1984Date of Patent: February 12, 1985Assignee: Meiji Seika Kaisha, Ltd.Inventors: Nobuto Minowa, Shunzo Fukatsu, Kunitaka Tachibana, Taro Niida, Sadaaki Mase
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Patent number: 4474764Abstract: New 3-N-acyl derivatives of 3-amino-2-hydroxy-4-phenylbutanoic acid are provided, which exhibit analgesic activity and are affective to enhance the morphine analgesia.Type: GrantFiled: September 28, 1982Date of Patent: October 2, 1984Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Tomio Takeuchi, Takaaki Aoyagi, Mitsugu Hachisu, Kenji Kawamura, Shunzo Fukatsu, Yasuharu Sekizawa
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Patent number: 4473554Abstract: 3-Amino-2-hydroxy-4-phenylbutanoic acid and esters thereof as well as new derivatives thereof which are related to bestatin in their chemical structure are active to enhance the immune response in living animals.Type: GrantFiled: November 8, 1982Date of Patent: September 25, 1984Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Tomio Takeuchi, Takaaki Aoyagi, Kenji Kawamura, Shunzo Fukatsu
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Patent number: 4472576Abstract: Disclosed is a process for preparing antibiotic 1-oxadethiacephalosporins via diazo-species I: ##STR1## wherein: A is acyl; R.sup.1 is H or OCH.sub.3 ; and R.sup.2 is a protecting group.Type: GrantFiled: December 3, 1982Date of Patent: September 18, 1984Assignee: Merck & Co., Inc.Inventors: Tadashi Wakazawa, Taro Niida, Shunzo Fukatsu, Yasushi Murai, Tsuneo Okonogi, Seiji Shibahara
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Patent number: 4455419Abstract: 2'-Modified kanamycins, including 2'-deoxykanamycin A, 2'-epikanamycin A and 2'-epikanamycin B, as new compounds are produced starting from kanamycin A by consecutive reaction steps. These new compounds are useful as antibacterial agent.Type: GrantFiled: July 16, 1982Date of Patent: June 19, 1984Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Sumio Umezawa, Yoshiharu Ishido, Shunzo Fukatsu
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Patent number: 4418070Abstract: A 5-phenylthiazole derivative represented by the formula: ##STR1## wherein R represents a hydrogen atom, a lower alkyl group, a hydroxyl group, an amino group or a mercapto group, or a pharmaceutically acceptable salt thereof shows a cardiac effect and a low toxicity to a human or animal with little influence on atrium rhythms.Type: GrantFiled: February 4, 1982Date of Patent: November 29, 1983Assignee: Meiji Seika Kabushiki KaishaInventors: Tsuneo Okonogi, Shunzo Fukatsu, Mitsugu Hachisu, Hiroko Kawashima, Keiko Shitoh, Yasuharu Sekizawa