Abstract: The present invention provides a valved vascular prosthesis and a manufacturing method thereof. The valved vascular prosthesis, comprising an artificial blood vessel and a valve disposed inside for obstruction; the valve is in a skirt state extending toward the centerline of the artificial blood vessel; the valve is made by sewing a tubular vascular material on the artificial blood vessel; one end of the vascular material is connected to the artificial blood vessel along its radial direction, and the other end is a free end; the entire tubular body of the vascular material is sewed on the artificial blood vessel by a plurality of sutures; the sutures are radially parallel to the tubular body of the vascular material, and are arranged at intervals along the circumference of the tubular body of the vascular material. The valved vascular prosthesis of the present invention adopts suture of a polymer material and an artificial blood vessel.

Abstract: The present disclosure relates to systems, methods, and computer-readable media for facilitating the transparent insertion of network virtual appliances into a cloud computing system. For example, a transparent network virtual appliance system can dynamically, seamlessly, and quickly add one or more network virtual appliances utilizing a chained gateway load balancer. In particular, the transparent network virtual appliance system can provide additional services to an application virtual network within a cloud computing system without disrupting or modifying the existing architecture of the cloud computing system.

Abstract: The present invention provides a valved vascular prosthesis and a manufacturing method thereof. The valved vascular prosthesis, comprising an artificial blood vessel and a valve disposed inside for obstruction; the valve is in a skirt state extending toward the centerline of the artificial blood vessel; the valve is made by sewing a tubular vascular material on the artificial blood vessel; one end of the vascular material is connected to the artificial blood vessel along its radial direction, and the other end is a free end; the entire tubular body of the vascular material is sewed on the artificial blood vessel by a plurality of sutures; the sutures are radially parallel to the tubular body of the vascular material, and are arranged at intervals along the circumference of the tubular body of the vascular material. The valved vascular prosthesis of the present invention adopts suture of a polymer material and an artificial blood vessel.

Abstract: A compound of Formula I, a pharmaceutically acceptable salt thereof, a prodrug thereof, or combinations thereof: wherein R1 is H, methyl, or benzyl; R2 is 2-cyanoethyl, 2-methoxycarbonylethyl, or 2-iodoethyl; X is N or S; wherein if X=S, R2=O; Y is C3 or C4; Z1 is O, S, N, or CH2; and Z2 is N or CR4, wherein R4 is a halogen, alkyl, aryl or a 5- or 6-membered heterocycle; and wherein said compound is selective for DOT1L Methyl Transferase.