Patents by Inventor Shuo Sui

Shuo Sui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENZYMATIC METHODS TO GENERATE HIGH YIELDS OF SEQUENCE SPECIFIC RNA OLIGONUCLEOTIDES WITH EXTREME PRECISION
    Publication number: 20260103737
    Abstract: Described herein are synthetic methods for producing sequence-specific RNA oligonucleotides that eliminate impurities produced in prior art methods. In one aspect, an end-protected capture DNA complementary to a portion of the product RNA is employed. In another aspect, the template DNA is covalently or noncovalently linked to the RNA polymerase, either directly or through the use of a nontemplate DNA. In a third aspect, a flow chamber is employed. All of the methods can be used in combination.
    Type: Application
    Filed: May 9, 2025
    Publication date: April 16, 2026
    Inventors: Craig Martin, Elvan Cavac, Kithmie Harshana Malagodapathiranage, Shuo Sui, Sarah L. Perry, Yasaman Gholamalipour
  • Enzymatic methods to generate high yields of sequence specific RNA oligonucleotides with extreme precision
    Patent number: 12325873
    Abstract: Described herein are synthetic methods for producing sequence-specific RNA oligonucleotides that eliminate impurities produced in prior art methods. In one aspect, an end-protected capture DNA complementary to a portion of the product RNA is employed. In another aspect, the template DNA is covalently or noncovalently linked to the RNA polymerase, either directly or through the use of a nontemplate DNA. In a third aspect, a flow chamber is employed. All of the methods can be used in combination.
    Type: Grant
    Filed: January 10, 2023
    Date of Patent: June 10, 2025
    Assignee: University of Massachusetts
    Inventors: Craig Martin, Elvan Cavac, Kithmie Harshana Malagodapathiranage, Shuo Sui, Sarah L. Perry, Yasaman Gholamalipour
  • NOVEL ENZYMATIC METHODS TO GENERATE HIGH YIELDS OF SEQUENCE SPECIFIC RNA OLIGONUCLEOTIDES WITH EXTREME PRECISION
    Publication number: 20230265477
    Abstract: Described herein are synthetic methods for producing sequence-specific RNA oligonucleotides that eliminate impurities produced in prior art methods. In one aspect, an end-protected capture DNA complementary to a portion of the product RNA is employed. In another aspect, the template DNA is covalently or noncovalently linked to the RNA polymerase, either directly or through the use of a nontemplate DNA. In a third aspect, a flow chamber is employed. All of the methods can be used in combination.
    Type: Application
    Filed: January 10, 2023
    Publication date: August 24, 2023
    Inventors: Craig Martin, Elvan Cavac, Kithmie Harshana Malagodapathiranage, Shuo Sui, Sarah L. Perry, Yasaman Gholamalipour
  • Enzymatic methods to generate high yields of sequence specific rna with extreme precision
    Patent number: 11578348
    Abstract: Described herein are synthetic methods for producing sequence-specific RNA oligonucleotides that eliminate impurities produced in prior art methods. In one aspect, an end-protected capture DNA complementary to a portion of the product RNA is employed. In another aspect, the template DNA is covalently or noncovalently linked to the RNA polymerase, either directly or through the use of a nontemplate DNA. In a third aspect, a flow chamber is employed. All of the methods can be used in combination.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: February 14, 2023
    Assignee: THE UNIVERSITY OF MASSACHUSETTS
    Inventors: Craig Martin, Elvan Cavac, Kithmie Harshana Malagodapathiranage, Shuo Sui, Sarah L. Perry, Yasaman Gholamalipour
  • NOVEL ENZYMATIC METHODS TO GENERATE HIGH YIELDS OF SEQUENCE SPECIFIC RNA OLIGONUCLEOTIDES WITH EXTREME PRECISION
    Publication number: 20200340028
    Abstract: Described herein are synthetic methods for producing sequence-specific RNA oligonucleotides that eliminate impurities produced in prior art methods. In one aspect, an end-protected capture DNA complementary to a portion of the product RNA is employed. In another aspect, the template DNA is covalently or noncovalently linked to the RNA polymerase, either directly or through the use of a nontemplate DNA. In a third aspect, a flow chamber is employed. All of the methods can be used in combination.
    Type: Application
    Filed: April 24, 2020
    Publication date: October 29, 2020
    Inventors: Craig Martin, Elvan Cavac, Kithmie Harshana Malagodapathiranage, Shuo Sui, Sarah L. Perry, Yasaman Gholamalipour
  • Microfluidic devices having top and bottom layers of graphene and a middle layer with a patterned cavity
    Patent number: 10792657
    Abstract: This invention provides microfluidic devices with graphene films as architectural materials and methods of fabrication and use thereof in X-ray analysis.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: October 6, 2020
    Assignee: University of Massachusetts
    Inventors: Shuo Sui, Yuxi Wang, Christos Dimitrakopoulos, Sarah L. Perry
  • MICROFLUIDIC DEVICES AND METHODS OF MANUFACTURE AND USE THEREOF
    Publication number: 20180214863
    Abstract: This invention provides microfluidic devices with graphene films as architectural materials and methods of fabrication and use thereof in X-ray analysis.
    Type: Application
    Filed: December 4, 2017
    Publication date: August 2, 2018
    Inventors: Shuo Sui, Yuxi Wang, Christos Dimitrakopoulos, Sarah L. Perry