Abstract: A method for forming an optical fiber having at least one of a microresonator and a coupler integrated therein is described. The method includes providing an optical fiber having a light guiding core. modifying at least one region of the optical fiber using a laser, immersing the optical fiber having the at least one region as modified inside an etchant that selectively etches the at least one region as modified to generate at least one of a microresonator and a coupler integrated in the optical fiber, and removing the optical fiber from the etchant. The optical fiber as removed from the etchant may include the at least one of the microresonator and the coupler. The method may further include heating the optical fiber using, for example, a CO2 laser or other heating apparatus, to smoothen surface irregularities of at least one of the microresonator and the coupler.

Abstract: The present disclosure provides a double-stranded RNAi agent for targeting and regulating HBV gene expression and a use thereof. The double-stranded RNAi agent comprises an antisense strand and a sense strand complementary to the antisense strand forming a duplex region. The nucleotide sequence of the antisense strand is as shown in SEQ ID NO: 8, 11, or 13, or the nucleotide sequence of the antisense strand is a modified sequence of the sequence shown in SEQ ID NO: 8, 11, or 13. Results from cell and animal experiments demonstrate that the double-stranded RNAi agent provided in the present disclosure can significantly reduce the expression of one or more HBV genes, block the viral life cycle, and can be used to develop drugs for treating diseases related to HBV gene expression.

Abstract: The ceiling antenna includes a reflecting bottom plate, wherein the reflecting bottom plate has a via hole; a supporting plate, wherein the supporting plate is fixed to the reflecting bottom plate, and a plane where the supporting plate is located is perpendicular to a plane where the reflecting bottom plate is located; a radiation oscillator, wherein the radiation oscillator is adhered to the supporting plate, the radiation oscillator includes a first radiator, the first radiator has a grid-line-like structure, and a shape of an outer contour of the first radiator is a rectangle having at least one cut corner; and a connector, wherein the connector is located on one side of the reflecting bottom plate that is away from the radiation oscillator, the via hole exposes a part of area of the connector, and the connector is electrically connected to the radiation oscillator through the via hole.

Abstract: The present disclosure provides a polyamide composite, including the following components in parts by weight: 77.2 parts to 94.8 parts of PAXI/XT, 5 parts to 20 parts of a semi-crystalline polyamide, and 0.2 part to 0.8 part of a powder of organosilicon elastomer including a methacryloxy functional group. The semi-crystalline polyamide is at least one selected from the group consisting of PA66, PA610, PA612, PA106, PA1010, and PA1012, and the PAXI/XT is a copolymer of an aliphatic diamine X, isophthalic acid I, and terephthalic acid T. The polyamide composite has advantages such as high light transmittance, high haze (excellent light-scattering performance), and prominent chemical resistance, and is suitable for the preparation of navigation lights for plant protection drones.

Abstract: Disclosed herein are synthetic nanoparticles, pharmaceutical compositions, kits, or methods for treating and/or preventing cancer. In some embodiments, the synthetic nanoparticles and/or pharmaceutical compositions comprises a pH sensitive liposome, an apolipoprotein, and andrographolide or derivative thereof. In some embodiments, the synthetic nanoparticles are delivered to a subject for treatment of cancer. In some embodiments, the cancer is T-cell lymphoma or B-cell lymphoma.

Abstract: Among the various aspects of the present disclosure is the provision of a disposable fiber optic sensor device for assessing tissue biomechanical properties. Disclosed herein is a fiber-optic sensor device that includes an optical fiber with a fiber tip, a displacement driver, and an interrogation system. A method to measure a biomechanical property of a tissue is also disclosed, which includes using a fiber optic sensor device to compress the targeted tissue with predefined displacement and frequency, where the counterforce deforms the soft cavity and, in turn, modulates the interference pattern is also disclosed.

Abstract: The present disclosure provides a modified oligonucleotide sequence and use thereof. A series of siRNAs were designed based on the angiotensinogen (AGT) messenger ribonucleic acid (mRNA) sequence, which were alternately modified or modified using a specific set of modification templates. The results from cell and animal experiments demonstrated that some oligonucleotide sequences with alternating modifications and specific template modifications can significantly inhibit AGT gene expression and may be used for the development of medicaments for treating hypertension and other related diseases.

Abstract: The present disclosure provides a GalNAc monomer comprising a ribose ring or a derivative structure thereof and a use thereof in liver-targeted delivery of small nucleic acid drugs. Specifically provided is a compound of formula (I) or a pharmaceutically acceptable salt thereof. The GalNAc-conjugated oligonucleotide prepared from the GalNAc compound provided by the present disclosure can achieve efficient liver-targeted delivery and enhance drug efficacy.

Abstract: Aspects of triboelectric fibers and methods of manufacture of the fibers are described. In one example, a method of manufacture of a fiber for generating energy using the triboelectric effect includes forming a preform tube, heating the preform tube in a furnace, feeding a wire through the preform tube and the furnace during the heating, and pulling the wire through the furnace to form a fiber. The methods described herein can be relied upon to manufacture fibers long enough for industrial-scale textile manufacturing, including for use with industrial-scale looms. In one example, forming the preform tube can include providing a polypropylene tube and wrapping the polypropylene tube with a housing layer of amorphous film, such as acrylic film. The acrylic film can be relied upon to maintain the form and integrity of the polypropylene as the wire is pulled, and the acrylic film can be easily removed after the pulling.

Abstract: A filter circuit, a filter, and an electronic device are disclosed. The filter circuit includes: a first port and a second port arranged opposite to each other, a grounding terminal, a series branch between the first port and the second port, and at least one parallel branch connected with the series branch; where the series branch includes at least one series resonance unit arranged in sequence, each of the at least one parallel branch includes a parallel resonance unit, and the parallel resonance unit is connected with the grounding terminal.

Abstract: An antenna includes: a first substrate and a second substrate. The first substrate includes: a first dielectric substrate, a first reference electrode layer, a first radiation part, and a feeder group. The first dielectric substrate includes a main substrate and a side substrate, the feeder group includes at least one feeder, in each of which, each feeder is electrically connected to one first radiation part, and different feeders are electrically connected to different first radiation parts. The second substrate includes: a second dielectric substrate, a second reference electrode layer, and a feed structure. The feed structure corresponds to the feeder group, and for corresponding feed structure and feeder group, each first feed port in the feed structure is electrically connected to one feeder in the feeder group through a first connection via which runs through at least the side substrate, the second reference electrode layer, and the second dielectric substrate.

Abstract: A fold testing device, including a support mechanism, an adjusting mechanism, and an attaching mechanism. The support mechanism includes a supporting body, a first position limiting part, and a second position limiting part. The first position limiting part and the second position limiting part are arranged on a side of the supporting body along a first direction. The supporting body, the first position limiting part and the second position limiting part are enclosed to form a positioning part. A flexible display module is received in the positioning part. The adjusting mechanism is installed on the supporting body, and configured to drive at least one of the first position limiting part and the second position limiting part to move along the first direction. The attaching mechanism includes an elastic attaching body. The elastic attaching body is movable toward the supporting body along a second direction. The elastic attaching body engages with the positioning part.

Abstract: Provided are a GalNAc compound containing a ribose ring or its derivative structure and an oligonucleotide conjugate thereof. The oligonucleotide conjugate can achieve efficient liver-targeted delivery and improve the efficacy of the drug.