Abstract: The disclosure relates to a field of electrical technology, and particularly discloses an electrical apparatus, a door opening and closing device and a control method of a clutch thereof. The door opening and closing device includes: a drive mechanism, a door ejection mechanism, a door rotation mechanism and an angle acquisition unit. a drive mechanism including a driver, a first transmission assembly, a second transmission assembly connected to the driver and simultaneously separably connected to the first transmission assembly, and a clutch-ejection-push assembly pushing the second transmission assembly to separate from or connect to the first transmission assembly; and a linkage gear connected to the first transmission assembly and simultaneously connected to the door ejection mechanism 00) and the door rotation mechanism. The angle acquisition unit is configured to acquire a rotation angle of the linkage gear.

Abstract: A method for forming an optical fiber having at least one of a microresonator and a coupler integrated therein is described. The method includes providing an optical fiber having a light guiding core. modifying at least one region of the optical fiber using a laser, immersing the optical fiber having the at least one region as modified inside an etchant that selectively etches the at least one region as modified to generate at least one of a microresonator and a coupler integrated in the optical fiber, and removing the optical fiber from the etchant. The optical fiber as removed from the etchant may include the at least one of the microresonator and the coupler. The method may further include heating the optical fiber using, for example, a CO2 laser or other heating apparatus, to smoothen surface irregularities of at least one of the microresonator and the coupler.

Abstract: The present disclosure provides a double-stranded RNAi agent for targeting and regulating HBV gene expression and a use thereof. The double-stranded RNAi agent comprises an antisense strand and a sense strand complementary to the antisense strand forming a duplex region. The nucleotide sequence of the antisense strand is as shown in SEQ ID NO: 8, 11, or 13, or the nucleotide sequence of the antisense strand is a modified sequence of the sequence shown in SEQ ID NO: 8, 11, or 13. Results from cell and animal experiments demonstrate that the double-stranded RNAi agent provided in the present disclosure can significantly reduce the expression of one or more HBV genes, block the viral life cycle, and can be used to develop drugs for treating diseases related to HBV gene expression.

Abstract: The ceiling antenna includes a reflecting bottom plate, wherein the reflecting bottom plate has a via hole; a supporting plate, wherein the supporting plate is fixed to the reflecting bottom plate, and a plane where the supporting plate is located is perpendicular to a plane where the reflecting bottom plate is located; a radiation oscillator, wherein the radiation oscillator is adhered to the supporting plate, the radiation oscillator includes a first radiator, the first radiator has a grid-line-like structure, and a shape of an outer contour of the first radiator is a rectangle having at least one cut corner; and a connector, wherein the connector is located on one side of the reflecting bottom plate that is away from the radiation oscillator, the via hole exposes a part of area of the connector, and the connector is electrically connected to the radiation oscillator through the via hole.

Abstract: The present disclosure provides a polyamide composite, including the following components in parts by weight: 77.2 parts to 94.8 parts of PAXI/XT, 5 parts to 20 parts of a semi-crystalline polyamide, and 0.2 part to 0.8 part of a powder of organosilicon elastomer including a methacryloxy functional group. The semi-crystalline polyamide is at least one selected from the group consisting of PA66, PA610, PA612, PA106, PA1010, and PA1012, and the PAXI/XT is a copolymer of an aliphatic diamine X, isophthalic acid I, and terephthalic acid T. The polyamide composite has advantages such as high light transmittance, high haze (excellent light-scattering performance), and prominent chemical resistance, and is suitable for the preparation of navigation lights for plant protection drones.

Abstract: Disclosed herein are synthetic nanoparticles, pharmaceutical compositions, kits, or methods for treating and/or preventing cancer. In some embodiments, the synthetic nanoparticles and/or pharmaceutical compositions comprises a pH sensitive liposome, an apolipoprotein, and andrographolide or derivative thereof. In some embodiments, the synthetic nanoparticles are delivered to a subject for treatment of cancer. In some embodiments, the cancer is T-cell lymphoma or B-cell lymphoma.

Abstract: Among the various aspects of the present disclosure is the provision of a disposable fiber optic sensor device for assessing tissue biomechanical properties. Disclosed herein is a fiber-optic sensor device that includes an optical fiber with a fiber tip, a displacement driver, and an interrogation system. A method to measure a biomechanical property of a tissue is also disclosed, which includes using a fiber optic sensor device to compress the targeted tissue with predefined displacement and frequency, where the counterforce deforms the soft cavity and, in turn, modulates the interference pattern is also disclosed.

Abstract: The present disclosure provides a modified oligonucleotide sequence and use thereof. A series of siRNAs were designed based on the angiotensinogen (AGT) messenger ribonucleic acid (mRNA) sequence, which were alternately modified or modified using a specific set of modification templates. The results from cell and animal experiments demonstrated that some oligonucleotide sequences with alternating modifications and specific template modifications can significantly inhibit AGT gene expression and may be used for the development of medicaments for treating hypertension and other related diseases.

Abstract: The present disclosure provides a GalNAc monomer comprising a ribose ring or a derivative structure thereof and a use thereof in liver-targeted delivery of small nucleic acid drugs. Specifically provided is a compound of formula (I) or a pharmaceutically acceptable salt thereof. The GalNAc-conjugated oligonucleotide prepared from the GalNAc compound provided by the present disclosure can achieve efficient liver-targeted delivery and enhance drug efficacy.

Abstract: Aspects of triboelectric fibers and methods of manufacture of the fibers are described. In one example, a method of manufacture of a fiber for generating energy using the triboelectric effect includes forming a preform tube, heating the preform tube in a furnace, feeding a wire through the preform tube and the furnace during the heating, and pulling the wire through the furnace to form a fiber. The methods described herein can be relied upon to manufacture fibers long enough for industrial-scale textile manufacturing, including for use with industrial-scale looms. In one example, forming the preform tube can include providing a polypropylene tube and wrapping the polypropylene tube with a housing layer of amorphous film, such as acrylic film. The acrylic film can be relied upon to maintain the form and integrity of the polypropylene as the wire is pulled, and the acrylic film can be easily removed after the pulling.