Abstract: Microelectronic assemblies with glass cores that have undergone localized thermal healing and/or localized doping in regions adjacent to glass surface are disclosed. In one example, a microelectronic assembly includes a glass core having a first face, an opposing second face, a sidewall extending between the first face and the second face, a surface region, and a bulk region, where the surface region is a portion of the glass core that starts at a surface of the first face, the second face, or the sidewall and extends from the surface into the glass core by a total depth of up to about 50 micron, the bulk region is a portion of the glass core further away from the surface than the surface region, and a density of the surface region is higher than a density of the bulk region, e.g., at least about 5% higher or at least about 7.5% higher.

Abstract: The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria.

Abstract: The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria.

Abstract: The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria.

Abstract: The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria.

Abstract: The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria.

Abstract: The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria.

Abstract: The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria.

Abstract: The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria.

Abstract: The present invention provides pyridopyrimidinone compounds with desirable biological activity and toxicity profiles for the enhanced treatment and prevention of malaria. The invention also relates to methods of making such molecules.

Abstract: The present invention provides a drug delivery vehicle that can improve the pharmacokinetics of pharmacological agents. The invention relates to a multifunctional carrier capable of delivering a carried material such as a pharmacological agent or genetic material to a recipient. The multifunctional carrier includes a multifunctional core and a plurality of adduct molecules bonded thereto. The molecular carrier has surface functional groups which can be associated with a carried material. The carried material can be associated with the molecular carrier through covalent interactions or ionic interactions. The polyvalent core can be ethylene-diamine tetraacetic acid (EDTA) or succinic acid. The invention also relates to methods for producing and using such molecules.

Abstract: The present invention provides a drug delivery vehicle that can improve the pharmacokinetics of pharmacological agents. The invention relates to a multifunctional carrier capable of delivering a carried material such as a pharmacological agent or genetic material to a recipient. The multifunctional carrier includes a multifunctional core and a plurality of adduct molecules bonded thereto. The molecular carrier has surface functional groups which can be associated with a carried material. The carried material can be associated with the molecular carrier through covalent interactions or ionic interactions. The polyvalent core can be ethylene-diamine tetraacetic acid (EDTA) or succinic acid. The invention also relates to methods for producing and using such molecules.