Abstract: Disclosed are a composite nanomaterial based on a metal-organic framework (MOF) material loaded with horseradish peroxidase (HRP) and a preparation method and use thereof. The composite nanomaterial based on the MOF material loaded with HRP includes a hafnium-based MOF material and HRP loaded thereon, where the hafnium-based MOF material is formed by self-assembly of 2?-amino-1,1?:4,1?-terphenyl-4,4?-dicarboxylic acid and hafnium ions through a coordination bond.

Abstract: A near-infrared fluorescent small-molecule probe, a synthesis method thereof, and an application thereof are provided. The near-infrared fluorescent small-molecule probe is IR-780-F derived from IR-780, in which the basic structure of IR-780 is retained, an end of an alkyl carbon chain connected with a nitrogen (N) atom is changed by adding a trifluoromethyl group (—CF3) at the end. The IR-780-F shows excellent performance in photostability, targeting cancer cells and fluorescence imaging, and has low toxicity. It can be used for targeting tumor tissues, in vivo near-infrared fluorescence imaging, and photothermal therapy, which realizes an integration of diagnosis and treatment.

Abstract: The present invention discloses preparation and use of a nanoparticle-doped RNA hydrogel targeting to a triple negative breast cancer (TNBC). The RNA hydrogel is a pure RNA system formed in a rolling circle transcription manner. The transcription process generates a large number of GC bonds, which provides a large number of sites for the introduction of DOX. The large number of RNA copy structures generated by rolling circle replication is a polyanionic aggregate. Due to the strong electronegativity of the polyanionic aggregate, electropositive MnO2@Ce6 nanoparticles are introduced, such that the colloid cationic MnO2@Ce6 particles can be stabilized by the polyanionic hydrogel, and thus target into a breast cancer cell for synergistic treatment. It can be used for a drug slow release system, has good biocompatibility, and has broad prospects in the fields of growth inhibition effects on targeted MDA-MB-231 tumor cells, inhibition of cancer metastasis and recurrence, and the like.

Abstract: The present invention discloses preparation and use of a nanoparticle-doped RNA hydrogel targeting to a triple negative breast cancer (TNBC). The RNA hydrogel is a pure RNA system formed in a rolling circle transcription manner. The transcription process generates a large number of GC bonds, which provides a large number of sites for the introduction of DOX. The large number of RNA copy structures generated by rolling circle replication is a polyanionic aggregate. Due to the strong electronegativity of the polyanionic aggregate, electropositive MnO2@Ce6 nanoparticles are introduced, such that the colloid cationic MnO2@Ce6 particles can be stabilized by the polyanionic hydrogel, and thus target into a breast cancer cell for synergistic treatment. It can be used for a drug slow release system, has good biocompatibility, and has broad prospects in the fields of growth inhibition effects on targeted MDA-MB-231 tumor cells, inhibition of cancer metastasis and recurrence, and the like.

Abstract: A phosphor can be excited by UV, purple or blue light LED, its preparation method, and light emitting devices incorporating the same. The phosphor contains rare earth, silicon, alkaline-earth metal, halogen, and oxygen, as well as aluminum or gallium. Its General formula of is aLn2O3.MO.bM?2O3.fSiO2.cAXe:dR, wherein Ln is at least one metal element selected from a group consisting of Sc, Y, La, Pr, Nd, Gd, Ho, Yb and Sm; M is at least one metal element selected from a group consisting of Ca, Sr and Ba; M? is at least one metal element selected from Al and Ga; A is at least one metal element selected from a group consisting of Li, Na, K, Mg, Ca, Sr and Ba; X is at least one element selected from F and Cl; R is at least one metal element selected from a group consisting of Ce, Eu, Tb and Mn; 0.01?a?2, 0.35?b?4, 0.01?c?1, 0.01?d?0.3, 0.01?f?3, 0.6?e?2.4. The phosphor has broad emitting range, high efficiency, better uniformity and stability.

Abstract: A phosphor can be excited by UV, purple or blue light LED, its production and the light emitting devices. The general formula of the phosphor is LnaMb(O,F)12:(R3+,M?2+)x, wherein, Ln is at least one metal element selected from a group consisting of Sc, Y, La, Pr, Nd, Gd, Ho, Yb and Sm, 2.6?a?3.4; M is at least one element selected from a group consisting of B, Al and Ga, 4.5?b?5.5; R is at least one metal element selected from a group consisting of Ce and Tb; M? is at least one metal element selected from a group consisting of Ca, Sr, Ba, Mn and Zn, 0.001?x?0.4. The phosphor possesses broad emitting range, high efficiency, better uniformity and stability. A light emitting device can be obtained by incorporating this phosphor into a UV, purple or blue light emitting device.

Abstract: A phosphor can be excited by UV, purple or blue light LED, its preparation method, and light emitting devices incorporating the same. The phosphor contains rare earth, silicon, alkaline-earth metal, halogen, and oxygen, as well as aluminum or gallium. Its General formula of is aLn2O3.MO.bM?2O3.fSiO2.cAXe: dR, wherein Ln is at least one metal element selected from a group consisting of Sc, Y, La, Pr, Nd, Gd, Ho, Yb and Sm; M is at least one metal element selected from a group consisting of Ca, Sr and Ba; M? is at least one metal element selected from Al and Ga; A is at least one metal element selected from a group consisting of Li, Na, K, Mg, Ca, Sr and Ba; X is at least one element selected from F and Cl; R is at least one metal element selected from a group consisting of Ce, Eu, Tb and Mn; 0.01?a?2, 0.35?b?4, 0.01?c?1, 0.01?d?0.3, 0.01?f?3, 0.6?e?2.4. The phosphor has broad emitting range, high efficiency, better uniformity and stability.