Patents by Inventor Shutsung Liao

Shutsung Liao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8829213
    Abstract: Compounds of formula (I): in which R1, R2, R3, R3?, R4, R5, R6, R6?, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, A, D, X, Y, and Z are defined in the specification. Also disclosed is a method of using one of the compounds to lower the blood cholesterol level and treat cancer, atherosclerosis, diabetes, Alzheimer's disease, and corneal arcus.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: September 9, 2014
    Assignee: The University of Chicago
    Inventors: Dacheng Peng, John Kokontis, Richard Hiipakka, Shutsung Liao
  • Publication number: 20140088060
    Abstract: A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits, combinations, and compositions for treating a disorder in a subject where an activator of liver X alpha is indicated, such as in, for example, treating a high cholesterol disease.
    Type: Application
    Filed: November 27, 2013
    Publication date: March 27, 2014
    Applicant: University of Chicago
    Inventors: Ching Song, Shutsung Liao, Qing Dai
  • Publication number: 20110160174
    Abstract: A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits, combinations, and compositions for treating a disorder in a subject where an activator of liver X alpha is indicated, such as in, for example, treating a high cholesterol disease.
    Type: Application
    Filed: March 11, 2011
    Publication date: June 30, 2011
    Applicant: University of Chicago
    Inventors: Ching Song, Shutsung Liao, Qing Dai
  • Publication number: 20110059932
    Abstract: Compounds of formula (I): in which R1, R2, R3, R3?, R4, R5, R6, R6?, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, A, D, X, Y, and Z are defined in the specification. Also disclosed is a method of using one of the compounds to lower the blood cholesterol level and treat cancer, atherosclerosis, diabetes, Alzheimer's disease, and corneal arcus.
    Type: Application
    Filed: July 29, 2010
    Publication date: March 10, 2011
    Applicant: The University of Chicago
    Inventors: Dacheng Peng, John Kokontis, Richard Hiipakka, Shutsung Liao
  • Publication number: 20100093687
    Abstract: A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits, combinations, and compositions for treating a disorder in a subject where an activator of liver X alpha is indicated, such as in, for example, treating a high cholesterol disease.
    Type: Application
    Filed: December 14, 2009
    Publication date: April 15, 2010
    Applicant: University of Chicago
    Inventors: Ching Song, Shutsung Liao, Qing Dai
  • Publication number: 20070197484
    Abstract: A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits, combinations, and compositions for treating a disorder in a subject where an activator of liver X alpha is indicated, such as in, for example, treating a high cholesterol disease.
    Type: Application
    Filed: July 18, 2006
    Publication date: August 23, 2007
    Inventors: Ching Song, Shutsung Liao, Qing Dai
  • Publication number: 20070032464
    Abstract: This invention relates to methods for treating cancers.
    Type: Application
    Filed: October 7, 2005
    Publication date: February 8, 2007
    Inventors: Shutsung Liao, Junichi Fukuchi
  • Patent number: 7078396
    Abstract: A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits, combinations, and compositions for treating a disorder in a subject where an activator of liver X alpha is indicated, such as in, for example, treating a high cholesterol disease.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: July 18, 2006
    Assignee: ARCH Development Corporation
    Inventors: Ching Song, Shutsung Liao
  • Patent number: 7012069
    Abstract: A compound of formula (I): Each of R1, R2, R3, R4, R4?, R5, R6, R7, R11, R12, R15, R16, and R17, independently, is hydrogen, halo, alkyl, haloalkyl, hydroxy, amino, carboxyl, oxo, sulfonic acid, or alkyl that is optionally inserted with —NH—, —N(alkyl)—, —O—, —S—, —SO—, —SO2—, —O—SO2—, —SO2—O—, —SO3—O—, —CO—, —CO—O—, —O—CO—, —CO—NR?—, or —NR?—CO—; or R3 and R4 together, R4 and R5 together, R5 and R6 together, or R6 and R7 together are eliminated so that a C?C bond is formed between the carbons to which they are attached; each of R8, R9, R10, R13, and R14, independently, is hydrogen, halo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, or amino; n is 0, 1, or 2; A is alkylene, alkenylene, or alkynylene; and each of X, Y, and Z, independently, is alkyl, haloalkyl, —OR?, —SR?, —NR?R?, —N(OR?)R?, or —N(SR?)R?; or X and Y together are ?O, ?S, or ?NR?; wherein each of R? and R?, independently, is hydrogen, alkyl, or haloalkyl.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: March 14, 2006
    Assignee: ARCH Development Corporation
    Inventors: Ching Song, Shutsung Liao
  • Publication number: 20060025393
    Abstract: This invention relates to methods for treating cancers.
    Type: Application
    Filed: October 8, 2004
    Publication date: February 2, 2006
    Inventors: Shutsung Liao, Junichi Fukuchi
  • Publication number: 20050113426
    Abstract: A method for reducing food intake in a subject and a method for reducing the levels of an endocrine in a subject. The methods include administering to the subject in need thereof an effective amount of a compound of the formula: Also disclosed is a liposomal preparation which includes a liposome and a compound entrapped therein. The entrapped compound is of the formula shown above.
    Type: Application
    Filed: August 20, 2003
    Publication date: May 26, 2005
    Inventors: Shutsung Liao, Richard Hiipakka, Yung-Hsi Kao
  • Publication number: 20040152681
    Abstract: Steroid derivatives of this invention interact with nuclear liver X receptor (LXR) and ubiquitous receptor (UR) and can be used to treat a variety of LXR- or UR-mediated disorders.
    Type: Application
    Filed: November 10, 2003
    Publication date: August 5, 2004
    Applicant: Arch Development Corporation, an Illinois corporation
    Inventors: Shutsung Liao, Ching Song
  • Patent number: 6696484
    Abstract: Pharmaceutical compositions and methods for treating androgen related disorders. The pharmaceutical compositions may include a 5&agr;-reductase inhibitor, such as natural and synthetic flavanoids, catechols, curcumin-related substances, quinones, catechins, particularly epigallocatechin derivatives, fatty acids, and the salts, esters, analogues, pro-drugs, isomers, racemic mixtures, or derivatives of any of the foregoing. The use of testosterone (or DHT) combinations with the aforementioned 5&agr;-reductase inhibitor compounds is also contemplated.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: February 24, 2004
    Assignee: University of Chicago Office of Technology and Intellectual Property
    Inventors: Shutsung Liao, Richard Hiipakka
  • Publication number: 20040014734
    Abstract: The invention relates to compounds of formula (I) 1
    Type: Application
    Filed: April 11, 2003
    Publication date: January 22, 2004
    Inventors: Ching Song, Shutsung Liao, Junichi Fukuchi
  • Patent number: 6645955
    Abstract: Steroid derivatives of this invention interact with nuclear liver X receptor (LXR) and ubiquitous receptor (UR) and can be used to treat a variety of LXR- or UR-mediated disorders.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: November 11, 2003
    Assignee: Arch Development Corporation
    Inventors: Shutsung Liao, Ching Song
  • Patent number: 6610749
    Abstract: A method for reducing food intake in a subject and a method for reducing the levels of an endocrine in a subject comprising administering to the subject in need thereof an effective amount of a compound of the formula: wherein A is alkenyl, and each of Ra, Rb, Rc and Rd is herein defined.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: August 26, 2003
    Assignee: ARCH Development Corporation
    Inventors: Shutsung Liao, Richard A. Hiipakka, Yung-Hsi Kao
  • Publication number: 20030153541
    Abstract: Compositions, methods, combinations, and kits for treating a disorder related to elevated serum cholesterol concentration, for example, atherosclerosis, elevated LDL plasma levels, low HDL plasma levels, hypertriglyceridemia, hyperlipidemia, hypertension, hypercholesterolemia, cholesterol gallstones, lipid storage diseases, obesity, and diabetes. The compositions, methods, combinations, and kits of the present invention are pharmaceutical compositions comprising at least two of an LXR receptor modulator, a therapeutically effective amount of a catechin, and/or a therapeutically effective amount of a lipid regulating agent, such as a HMG-CoA reductase inhibitor, a fibric acid derivative, niacin, a bile-acid sequestrant, an absorption inhibitor, probucol, raloxifene and its derivatives, an azetidinone compound, and an unsaturated omega-3 fatty acid.
    Type: Application
    Filed: June 19, 2002
    Publication date: August 14, 2003
    Inventors: Robert Dudley, Shutsung Liao, Ching Song
  • Publication number: 20030144346
    Abstract: Compounds that inhibit 5&agr;-reductase are provided. The compounds are used to treat prostate cancer, breast cancer, obesity, skin disorders and baldness.
    Type: Application
    Filed: November 14, 2002
    Publication date: July 31, 2003
    Inventors: Shutsung Liao, Richard A. Hiipakka
  • Publication number: 20030139385
    Abstract: A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): 1
    Type: Application
    Filed: November 8, 2002
    Publication date: July 24, 2003
    Inventors: Ching Song, Shutsung Liao
  • Publication number: 20030139477
    Abstract: A method for reducing food intake in a subject and a method for reducing the levels of an endocrine in a subject.
    Type: Application
    Filed: February 15, 2001
    Publication date: July 24, 2003
    Inventors: Shutsung Liao, Richard A. Hiipakka, Yung-Hsi Kao