Abstract: The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently —N? or —CH?; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group —XA—N—XB—; XA and XB are each independently a bond, lower alkylene, etc.

Abstract: The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently —N? or —CH?; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group —XA—N—XB—; XA and XB are each independently a bond, lower alkylene, etc.

Abstract: The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently —N? or —CH?; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group —XA—N—XB—; XA and XB are each independently a bond, lower alkylene, etc.

Abstract: The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; Al is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.

Abstract: The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.

Abstract: The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.

Abstract: The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently —N? or —CH?; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group —XA—N—XB—; XA and XB are each independently a bond, lower alkylene, etc.

Abstract: The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.

Abstract: In a guide for a transmission chain, a slide rail elongated in the direction of travel of the chain, and having a front surface for sliding engagement with the chain, is supported by a rail support which extends perpendicularly from the back side of the slide rail. The guide is formed by sandwich molding and comprises a glass fiber-reinforced polymer resin forming a core of the rail support, and a wear-resistant polymer resin forming both the slide rail, and a skin layer on the rail support, the skin layer of the rail support being unitary with the slide rail. A plurality of hollow, heat-dissipating, cavities extend inwardly from both sides of the slide rail in directions transverse to the direction of elongation of the slide rail.

Abstract: In a guide for a transmission chain, a slide rail elongated in the direction of travel of the chain, and having a front surface for sliding engagement with the chain, is supported by a rail support which extends perpendicularly from the back side of the slide rail. The guide is formed by sandwich molding and comprises a glass fiber-reinforced polymer resin forming a core of the rail support, and a wear-resistant polymer resin forming both the slide rail, and a skin layer on the rail support, the skin layer of the rail support being unitary with the slide rail. A plurality of hollow, heat-dissipating, cavities extend inwardly from both sides of the slide rail in directions transverse to the direction of elongation of the slide rail.

Abstract: A guide for as transmission device such as a chain or belt, is injection molded using a sandwich-molding process. The sandwhich-molded guide comprises a slide rail on which a chain or belt slides, and a rail supporting member intergrally provided along with the slide rail. The slide rail is composed of a material the principle component of which is first polymeric material having wear resistance and heat resistance, and the rail supporting member is composed of a material the principle component of which is a second polymeric material having higher strength than the material having the first polymeric material as its principle component. The slide rail and the rail supporting member are intimately joined to each other by injection molding using the sandwhich molding process.

Abstract: An object of the present invention is to provide a hydraulic-composition bonded magnet having moldability, heat resistance, corrosion resistance and high strength. A hydraulic-composition bonded magnet according to the present invention is characterized by that a magnetic powder is held in a hydraulic composition produced by cure of a hydraulic powder. Preferably, in the hydraulic-composition bonded magnet, the hydraulic composition is cured together with a non-hydraulic powder. More preferably, a processing modifier is added to the hydraulic-composition bonded magnet.

Abstract: An object of the present invention is to provide a hydraulic-composition bonded magnet having moldability, heat resistance, corrosion resistance and high strength.

Abstract: A guide for a transmission device such as a chain or belt, is injection molded using a sandwich-molding process. The process avoids the need for a complex mold and complex manufacturing steps. The guide exhibits enhanced mechanical strength and excellent sliding contact properties and wear resistance in a compatible manner, and is also light in weight and has excellent durability. The sandwich-molded guide comprises a slide rail on which a chain or belt slides, and a rail supporting member integrally provided along with the slide rail. The slide rail is composed of a material the principal component of which is a first polymeric material having wear resistance and heat resistance, and the rail supporting member is composed of a material the principal component of which is a second polymeric material having higher strength than the material having the first polymeric material as its principal component.