Abstract: A method of making a magnetically-drivable microrobot that is suitable for carrying and delivering cells includes photo-curing a photo-curable material composition to form a body of the magnetically-drivable microrobot. The photo-curable material composition includes a degradable component, a structural component, a magnetic component, and a photo-curing facilitation composition including a photoinitiator component and a photosensitizer component.

Abstract: Two or more micropipettes are used to increase a microinjection throughput in an automated system for microinjecting adherent cells on a Petri dish. In the system, a motorized stage carrying the Petri dish sequentially visits the cells according to an optimized injection sequence. The sequence is selected by minimizing a total distance traveled by the motorized stage such that each cell is visited once by one of the micropipettes. Using multiple micropipettes advantageously reduces the minimized total distance over using a single micropipette to thereby increase the throughput. The optimized injection sequence is obtained by solving an equality-generalized traveling salesman problem. Each micropipette is mounted on a motorized micromanipulator. The motorized stage and motorized micromanipulators operate coordinately that each micromanipulator goes down or up during movement of the motorized stage to compensate for unevenness between a focus plane and a moving trajectory of the motorized stage.

Abstract: A method of making a magnetically-drivable microrobot that is suitable for carrying and delivering cells includes photo-curing a photo-curable material composition to form a body of the magnetically-drivable microrobot. The photo-curable material composition includes a degradable component, a structural component, a magnetic component, and a photo-curing facilitation composition including a photoinitiator component and a photosensitizer component.

Abstract: A cell-trapping device includes a microchannel portion for trapping a plurality of cells with an average diameter of at most 25 ?m for high-throughput microinjection of an injectant into the cells. The cell-trapping device includes a microchannel portion having formed therein a cell-trapping area including a plurality of cell-trapping microchannels configured to trap one cell per cell-trapping channel. A method for preparing the cell-trapping device and an apparatus for high-throughput microinjection is also provided. Further provided is a method for injecting an injectant into a plurality of cells. The cell-trapping device, apparatus, and method allow for a rapid and highly reproducible microinjection into small cells with high productivity, high accuracy and a good cell survival rate.

Abstract: The present invention is concerned with a system for fusion at least two cells. The system has an optical tweezers system for generating moving optical traps for manipulating the cells, an optical scissors system for cutting cell membrane of the cells and inducing fusion of the cells, an incubation system for providing cell culture in which the cells suspend and cell culture environment for the cells, and a visual detection system allowing visual monitoring of the cells undergoing fusion.