Patents by Inventor Shuyuan Zhang
Shuyuan Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220310668Abstract: An array substrate and a display device are provided. A functional layer of the array substrate is provided with a first opening in a bending region. A filling layer covering the functional layer fills the first opening and provides a second opening at a position of the first opening. A metal layer of the array substrate includes a plurality of metal traces, and the metal traces are bent toward an inside of the second opening in a region overlapping with the second opening.Type: ApplicationFiled: November 13, 2020Publication date: September 29, 2022Inventors: Jianfeng CHEN, Shuyuan ZHANG
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Patent number: 11436977Abstract: A pixel driving circuit, a method of driving thereof, and a display panel are provided. The pixel driving circuit includes a driving transistor and a compensation module, which at least includes different types of initialization transistors and compensation transistors. The compensation transistor transmits a data signal with a compensation threshold voltage to the gate of the driving transistor. The initialization transistor transmits the variable potential signal to the gate of the driving transistor to dynamically compensate the gate voltage of the driving transistor during the light-emitting phase, thereby improving the display effect.Type: GrantFiled: August 17, 2020Date of Patent: September 6, 2022Assignee: WUHAN CHINA STAR OPTOELECTRONICS SEMICONDUCTOR DISPLAY TECHNOLOGY CO., LTD.Inventors: Shuyuan Zhang, Sunghwan Cho, Chao Dai
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Publication number: 20220157239Abstract: A pixel driving circuit, a method of driving thereof, and a display panel are provided. The pixel driving circuit includes a driving transistor and a compensation module, which at least includes different types of initialization transistors and compensation transistors. The compensation transistor transmits a data signal with a compensation threshold voltage to the gate of the driving transistor. The initialization transistor transmits the variable potential signal to the gate of the driving transistor to dynamically compensate the gate voltage of the driving transistor during the light-emitting phase, thereby improving the display effect.Type: ApplicationFiled: August 17, 2020Publication date: May 19, 2022Inventors: Shuyuan ZHANG, Sunghwan CHO, Chao DAI
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Publication number: 20210139837Abstract: Electroporation is a technique in which an electrical field is applied to cells in order to increase the permeability of the cell membrane. This allows for chemicals, drugs, and/or macromolecules such as proteins and nucleic acids to be introduced into the cells. Embodiments relate to an electroporation apparatus. The electroporation apparatus comprises: a plurality of chambers configured to store a plurality of cells during an electroporation process; a plurality of electrodes configured to generate a plurality of electric fields within the plurality of chambers during the electroporation process, each electric field of the plurality of electric fields corresponding to one chamber of the plurality of chambers; a flow channel configured to transport the plurality cells during a cell collection process after the electroporation process; and a plurality of valves connecting the plurality of chambers to the flow channel.Type: ApplicationFiled: November 11, 2020Publication date: May 13, 2021Applicant: Precigen, Inc.Inventors: Shuyuan ZHANG, Bryan BUTMAN, Justin INSLEE, Robert SCHNEIDER, Kraig KRUGER, Travis ANDREWS, William HOCK, David CERRONE, Scott SCHMIDT, Jeffrey GENTRY, Mackenzie MILLER, Vincent SO, Chad B. GREEN
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Publication number: 20210011195Abstract: The present invention discloses a terahertz metamaterial. The terahertz metamaterial includes a substrate and an electromagnetic loss resonant ring structure disposed on the substrate, where an electromagnetic modulation function is realized on a terahertz band by adjusting different structural sizes and square resistance of the electromagnetic loss resonant ring structure. In the present invention, the electromagnetic loss resonant ring structure is disposed on the substrate, and the electromagnetic modulation function is realized on the terahertz band by adjusting the different structural sizes and square resistance of the electromagnetic loss resonant ring structure, thereby simplifying processing steps of a terahertz device, reducing a processing cost, and enabling a terahertz technology to be widely used in the field of electromagnetic communication.Type: ApplicationFiled: September 25, 2020Publication date: January 14, 2021Inventors: Ruopeng Liu, Wei Xiong, Jincai Ye, Jiawei He, Jinjin Wang, Jiangbo Chen, Shuyuan Zhang
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Patent number: 10870854Abstract: Embodiments of the present disclosure include compositions and methods related to certain siRNA compositions for the treatment of cancer. In specific embodiments, siRNAs are employed for treatment of cancer, including at least liver cancer. Therapeutic methods, compositions, and kits are encompassed in the disclosure.Type: GrantFiled: May 24, 2017Date of Patent: December 22, 2020Assignee: The Board of Regents of the University of Texas SystemInventors: Hao Zhu, Shuyuan Zhang
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Publication number: 20190153448Abstract: Embodiments of the present disclosure include compositions and methods related to certain siRNA compositions for the treatment of cancer. In specific embodiments, siRNAs are employed for treatment of cancer, including at least liver cancer. Therapeutic methods, compositions, and kits are encompassed in the disclosure.Type: ApplicationFiled: May 24, 2017Publication date: May 23, 2019Applicant: The Board of Regents of the University of Texas SystemInventors: Hao ZHU, Shuyuan ZHANG
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Publication number: 20190137655Abstract: The present invention discloses a terahertz metamaterial. The terahertz metamaterial includes a substrate and an electromagnetic loss resonant ring structure disposed on the substrate, where an electromagnetic modulation function is realized on a terahertz band by adjusting different structural sizes and square resistance of the electromagnetic loss resonant ring structure. In the present invention, the electromagnetic loss resonant ring structure is disposed on the substrate, and the electromagnetic modulation function is realized on the terahertz band by adjusting the different structural sizes and square resistance of the electromagnetic loss resonant ring structure, thereby simplifying processing steps of a terahertz device, reducing a processing cost, and enabling a terahertz technology to be widely used in the field of electromagnetic communications.Type: ApplicationFiled: August 18, 2016Publication date: May 9, 2019Applicants: KUANG-CHI INSTITUTE OF ADVANCED TECHNOLOGY, KUANG-CHI INNOVATIVE TECHNOLOGY LTD.Inventors: Ruopeng LIU, Wei XIONG, Jincai YE, Jiawei HE, Jinjin WANG, Jiangbo CHEN, Shuyuan ZHANG
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Patent number: 9628195Abstract: A gain-variable trans-impedance amplifier (TIA) in optical device is disclosed. The TIA has an improved dynamic range for receiving electrical signals and is configured to convert current signals from an avalanche photodiode (APD) to voltage signals. A resistor element is between the input and output terminals of the TIA, wherein the resistance of the resistor element can regulate the resistance and/or impedance value of the TIA, and a switch determines or controls the resistance of the resistor element. When the power of an optical signal received by the APD is higher than a predetermined value, the resistance becomes smaller and the gain of the TIA becomes greater. When the power of the optical signal is lower than the predetermined value, the resistance becomes greater. The gain of the TIA is automatically adjusted on the basis of the intensity of received optical signals to obtain a greater dynamic operational range.Type: GrantFiled: October 22, 2014Date of Patent: April 18, 2017Assignee: Source Photonics (Chengdu) Co., Ltd.Inventors: Xu Jiang, Yuan Song, Shuyuan Zhang, Yuanzhong Xu
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Publication number: 20160268981Abstract: A gain-variable trans-impedance amplifier (TIA) in optical device is disclosed. The TIA has an improved dynamic range for receiving electrical signals and is configured to convert current signals from an avalanche photodiode (APD) to voltage signals. A resistor element is between the input and output terminals of the TIA, wherein the resistance of the resistor element can regulate the resistance and/or impedance value of the TIA, and a switch determines or controls the resistance of the resistor element. When the power of an optical signal received by the APD is higher than a predetermined value, the resistance becomes smaller and the gain of the TIA becomes greater. When the power of the optical signal is lower than the predetermined value, the resistance becomes greater. The gain of the TIA is automatically adjusted on the basis of the intensity of received optical signals to obtain a greater dynamic operational range.Type: ApplicationFiled: October 22, 2014Publication date: September 15, 2016Applicant: SOURCE PHOTONICS (CHENGDU) CO., LTD.Inventors: Xu JIANG, Yuan SONG, Shuyuan ZHANG, Yuanzhong XU
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Patent number: 9428768Abstract: The present invention relates to improved methods for producing adenovirus compositions wherein host cells are grown in a bioreactor and purified by size partitioning purification to provide purified adenovirus compositions.Type: GrantFiled: October 28, 2009Date of Patent: August 30, 2016Assignee: Crucell Holland B.V.Inventors: Hai Pham, Shuyuan Zhang, Peter Clarke
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Publication number: 20160119061Abstract: A burst-mode laser control circuit and related methods thereof are disclosed. Using an APC loop with an additional burst-mode control circuit, and a switch in series with a diode and in parallel with the laser, a continuous-mode laser driver is enabled to operate in burst-mode by turning the switch on or off via external logic. Burst-mode control manages the switch, and a bandwidth-select circuit using a high or low logic level input, wherein the laser is disabled and the bandwidth-select circuit enters a fast-track mode when the external logic signal has a first level. The laser provides regular optical signals, and the bandwidth-select circuit enters a slow-track mode, thereby enabling the APC loop to operate normally, when the external logic signal has a second level. In addition to a low cost and simple implementation, the control circuit and method provide lasers with a fast response capability using one or more externally-controlled switch circuits to meet demands of PON systems for burst-mode ONUs.Type: ApplicationFiled: October 23, 2014Publication date: April 28, 2016Applicant: SOURCE PHOTONICS (CHENGDU) CO., LTD.Inventors: Xu JIANG, Yuan SONG, Shuyuan ZHANG, Yuanzhong XU
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Patent number: 9325421Abstract: A burst-mode laser control circuit and related methods thereof are disclosed. Using an APC loop with an additional burst-mode control circuit, and a switch in series with a diode and in parallel with the laser, a continuous-mode laser driver is enabled to operate in burst-mode by turning the switch on or off via external logic. Burst-mode control manages the switch, and a bandwidth-select circuit using a high or low logic level input, wherein the laser is disabled and the bandwidth-select circuit enters a fast-track mode when the external logic signal has a first level. The laser provides regular optical signals, and the bandwidth-select circuit enters a slow-track mode, thereby enabling the APC loop to operate normally, when the external logic signal has a second level. In addition to a low cost and simple implementation, the control circuit and method provide lasers with a fast response capability using one or more externally-controlled switch circuits to meet demands of PON systems for burst-mode ONUs.Type: GrantFiled: June 30, 2014Date of Patent: April 26, 2016Assignee: Source Photonics (Chengdu) Co., Ltd.Inventors: Xu Jiang, Yuan Song, Shuyuan Zhang, Yuanzhong Xu
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Patent number: 7888096Abstract: The present invention addresses the need to improve the long-term storage stability (i.e. infectivity) of vector formulations. In particular, it has been demonstrated that for adenovirus, the use of bulking agents, cryoprotectants and lyoprotectants imparts desired properties that allow both lyophilized and liquid adenovirus formulations to be stored at 4° C. for up to 6 months and retain an infectivity between 60-100% of the starting infectivity.Type: GrantFiled: June 26, 2007Date of Patent: February 15, 2011Assignee: Crucell Holland B.V.Inventors: Zheng Wu, Shuyuan Zhang
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Patent number: 7888097Abstract: The present invention addresses the need to improve the long-term storage stability (i.e. infectivity) of vector formulations. In particular, it has been demonstrated that for adenovirus, the use of bulking agents, cryoprotectants and lyoprotectants imparts desired properties that allow both lyophilized and liquid adenovirus formulations to be stored at 4° C. for up to 6 months and retain an infectivity between 60-100% of the starting infectivity.Type: GrantFiled: October 29, 2007Date of Patent: February 15, 2011Assignee: Crucell Holland B.V.Inventors: Zheng Wu, Shuyuan Zhang
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Patent number: 7732129Abstract: The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production with cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge.Type: GrantFiled: December 1, 1998Date of Patent: June 8, 2010Assignee: Crucell Holland B.V.Inventors: Shuyuan Zhang, Capucine Thwin, Zheng Wu, Toohyon Cho, Shawn Gallagher
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Publication number: 20100105124Abstract: The present invention relates to improved methods for producing adenovirus compositions wherein host cells are grown in a bioreactor and purified by size partitioning purification to provide purified adenovirus compositions.Type: ApplicationFiled: October 28, 2009Publication date: April 29, 2010Inventors: Hai Pham, Shuyuan Zhang, Peter Clarke
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Publication number: 20100055763Abstract: The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production with cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge.Type: ApplicationFiled: October 2, 2009Publication date: March 4, 2010Inventors: SHUYUAN ZHANG, Capucine Thwin, Zheng Wu, Toohyon Cho
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Publication number: 20090253184Abstract: Embodiments of the invention include E1 expressing cell lines that can be used in a variety of methods for production of an E1 defective adenovirus. In certain aspects a cell of the invention can be adapted to various culture conditions, e.g., suspension culture in serum free medium. In a further aspect, the cell lines allow isolation and subculture of E1-deleted recombinant adenoviruses in an environment free of replication competent adenovirus (RCA).Type: ApplicationFiled: January 23, 2009Publication date: October 8, 2009Applicant: Introgen Therapeutics, Inc.Inventors: Peter Clarke, Shuyuan Zhang, Hai Pham, Joe Senesac
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Patent number: D640140Type: GrantFiled: June 29, 2010Date of Patent: June 21, 2011Inventor: Shuyuan Zhang