Abstract: The present disclosure relates to epitope peptides for tumor-associated antigens and use thereof. The epitope peptides for tumor-associated antigens are derived from embryonic stem cells, and NUF-2. Studies have found that among embryonic stem cell-derived tumor-associated antigens selected from at least one of CENPM, IQGA3-1, IQGA3-2, KIF4A-1, KIF4A-2, and NUF-2, the tumor-associated antigens KIF4A and NUF-2 expressed by embryonic stem cells (ESCs) can effectively inhibit the growth of bladder cancer, and the tumor-associated antigens CENPM, NUF-2, and IQGA3 expressed by the ESCs can strongly stimulate the immune response of specific T cells, which is manifested by stimulating peptide-specific CTL to secrete high levels of IFN-? and inhibiting tumor growth, and the epitope peptides for tumor-associated antigens can be used in the preparation of a medicament for inhibiting the growth of tumor cells or stimulating immune cells to produce a T cell response.

Abstract: A system and method is disclosed for providing route guidance for an electric vehicle. The electric vehicle may use static traffic data (e.g., speed limit, traffic lights, stop signs) and non-static traffic data (e.g., vehicular accidents, road closures, construction) to calculate driving routes between a current location and a destination location. The driving routes may be adjusted to account for the ambient temperature external to the electric vehicle. The driving routes may also be adjusted to account for internal loads (e.g., air conditioning system or heating system) that may exhausted by the battery to the electric motor to propel the electric vehicle along the driving routes. A display unit may accentuate a target driving route that would require the least amount of power be expended by the battery.

Abstract: An electric machine assembly for a vehicle is provided. The electric machine is in operational communication with a traction battery and includes a stator core defining a cavity and a rotor disposed within the cavity having an inner region defined by sets of triangle-shaped holes tessellated about respective central regions to form a truss structure such that the holes of the truss structure, during operational rotation, do not influence magnetic flux paths generated by magnets of the rotor. The rotor may have a strain energy value less than or equal to 16,100 Joules. The truss structure may include pairs of symmetrical portions each including segments arranged with adjacent rotor portions to define the triangle-shaped holes.

Abstract: An electric motor/generator includes a stator-core enclosing a rotor-core, which are each formed from stacked annular laminates. The stator-core laminates are configured to reduce vibration, and each have teeth extending radially inward from a root of an annular stator yoke/back-iron, to a flux-cap. Each tooth is formed to have opposite, lateral-edges spaced a distance-apart that changes between the root to the flux-cap, to establish a variable tooth-stiffness and a predetermined mechanical-resonance of the tooth. The opposite lateral-edges may each be configured with either a linear or a non-linear, curved edge-profile, and to have the variable tooth-stiffness and the lateral-edge distance-apart changing or decreasing between the root and the flux-cap. Each tooth may also have an edge-profile that is different from at least one adjacent tooth, and which is configured with a variable tooth-stiffness and a predetermined mechanical resonance that is different from the at least one adjacent tooth.

Abstract: An electric machine assembly for a vehicle is provided. The electric machine is in operational communication with a traction battery and includes a stator core defining a cavity and a rotor disposed within the cavity having an inner region defined by sets of triangle-shaped holes tessellated about respective central regions to form a truss structure such that the holes of the truss structure, during operational rotation, do not influence magnetic flux paths generated by magnets of the rotor. The rotor may have a strain energy value less than or equal to 16,100 Joules. The truss structure may include pairs of symmetrical portions each including segments arranged with adjacent rotor portions to define the triangle-shaped holes.

Abstract: An electric motor/generator includes a stator-core enclosing a rotor-core, which are each formed from stacked annular laminates. The stator-core laminates are configured to reduce vibration, and each have teeth extending radially inward from a root of an annular stator yoke/back-iron, to a flux-cap. Each tooth is formed to have opposite, lateral-edges spaced a distance-apart that changes between the root to the flux-cap, to establish a variable tooth-stiffness and a predetermined mechanical-resonance of the tooth. The opposite lateral-edges may each be configured with either a linear or a non-linear, curved edge-profile, and to have the variable tooth-stiffness and the lateral-edge distance-apart changing or decreasing between the root and the flux-cap. Each tooth may also have an edge-profile that is different from at least one adjacent tooth, and which is configured with a variable tooth-stiffness and a predetermined mechanical resonance that is different from the at least one adjacent tooth.

Abstract: A powertrain for a vehicle includes and electric machine and a plurality of inverters. The electric machine may include a stator defining a plurality of stator teeth separated by slots that are configured to accept windings. The plurality of inverters may each be configured to exclusively drive a current in some but not all of the windings within slots such that some of the plurality of stator teeth within a sector of the stator are configured to be energized by only one of the inverters.

Abstract: A powertrain for a vehicle includes and electric machine and a plurality of inverters. The electric machine may include a stator defining a plurality of stator teeth separated by slots that are configured to accept windings. The plurality of inverters may each be configured to exclusively drive a current in some but not all of the windings within slots such that some of the plurality of stator teeth within a sector of the stator are configured to be energized by only one of the inverters.