Abstract: It is an object of the present invention to provide antibodies against coronavirus (SARS-CoV-2). It is also an object of the present invention to provide a pharmaceutical composition against coronavirus infection using the antibody. According to the present invention, an antibody or antigen-binding fragment thereof that binds to the receptor-binding domain present in the spike protein of coronavirus and is capable of neutralizing the coronavirus, and a pharmaceutical composition for the prevention or treatment of coronavirus infection containing the antibody or antigen-binding fragment, are provided.

Abstract: CD4 mimic compounds having improved efficacy for anti-HIV treatment and more improved pharmacokinetics are provided. The compounds are represented by formula (I): wherein R1 is C2H4(OC2H4)n—OCH3 or CmH2m+1; R2 is O or NH; n is 3 to 25; and m is 4 to 22, or a salt thereof. HIV infection inhibitor compositions including the compound or a salt thereof as an active ingredient are also disclosed.

Abstract: The present inventors have conducted intensive studies on an antibody which controls HIV in an administration group with a high probability over a long period of time with one or several times of single-agent administration. As a result, the present inventors have surprisingly found that, when an SW-1C10 antibody, which is obtained by producing an antibody gene reported as 1C10 in silkworms, is singly administered only a few times, the viral load in the blood is suppressed to the detection limit or lower at an early stage in all of individuals to which the antibody has been administered, and moreover, the viral RNA load in the blood is maintained at the detection limit or lower for a long time of 12 weeks. Also, the yield of the antibody in silkworms is approximately several hundreds ?g per cocoon, or several ?g per 1 mg of cocoon, and studies to increase the productivity more than this level have not been conducted heretofore.

Abstract: There is provided an optical transmitter including a memory, a processor coupled to the memory and the processor to generate an electric signal, an optical generator to generate light, an optical modulator to modulate the light with the electric signal to create an optical signal, a first voltage electrode to apply a first voltage to the optical signal, a second voltage electrode to apply a second voltage to the optical signal to which the first voltage is applied, and a detector to detect an optical power of the optical signal to which the second voltage is applied, wherein the processor stops generating the electric signal, controls the first voltage electrode to change the first voltage after the stop of generating the electric signal, and controls the second voltage electrode to change the second voltage according to the detected optical power after the change of the first voltage.

Abstract: There is provided a transmitting device including a receiver configured to receive a signal including one of a first signal to which a code relating to error correction is assigned and a second signal to which the code is not assigned, a first synchronization processing circuit configured to perform a first synchronization processing of the first signal, a second synchronization processing circuit configured to perform a second synchronization processing of the second signal, and a switch circuit configured to select one of the signal including the first signal and the signal including the second signal, based on results of the first synchronization processing and the second synchronization processing.

Abstract: There is provided an optical transmitter including a memory, a processor coupled to the memory and the processor to generate an electric signal, an optical generator to generate light, an optical modulator to modulate the light with the electric signal to create an optical signal, a first voltage electrode to apply a first voltage to the optical signal, a second voltage electrode to apply a second voltage to the optical signal to which the first voltage is applied, and a detector to detect an optical power of the optical signal to which the second voltage is applied, wherein the processor stops generating the electric signal, controls the first voltage electrode to change the first voltage after the stop of generating the electric signal, and controls the second voltage electrode to change the second voltage according to the detected optical power after the change of the first voltage.

Abstract: An optical transmission apparatus includes: an optical receiver configured to receive an optical signal; a variable optical attenuator configured to adjust a power of the optical signal to be input to the optical receiver according to a variable attenuation amount; and a controller configured to control the attenuation amount of the variable optical attenuator based on an electrical signal obtained by performing a coherent detection and a photoelectric conversion on the optical signal received by the optical receiver.

Abstract: An optical transmission apparatus includes: an optical receiver configured to receive an optical signal; a variable optical attenuator configured to adjust a power of the optical signal to be input to the optical receiver according to a variable attenuation amount; and a controller configured to control the attenuation amount of the variable optical attenuator based on an electrical signal obtained by performing a coherent detection and a photoelectric conversion on the optical signal received by the optical receiver.

Abstract: The present invention provides a monoclonal antibody that recognizes the V3 loop of the envelope glycoprotein gp120 of AIDS virus, which is any one selected from the following antibodies: (a) an antibody having the amino acid sequence shown in SEQ ID NO: 1 as the amino acid sequence of a H chain variable region (VH), and having the amino acid sequence shown in SEQ ID NO: 2 as the amino acid sequence of a L chain variable region (VL); and (b) an antibody having the amino acid sequence shown in SEQ ID NO: 3 as the amino acid sequence of a H chain variable region (VH), and having the amino acid sequence shown in SEQ ID NO: 4 as the amino acid sequence of a L chain variable region (VL).

Abstract: The present invention provides a monoclonal antibody that recognizes the V3 loop of the envelope glycoprotein gp120 of AIDS virus, which is any one selected from the following antibodies: (a) an antibody having the amino acid sequence shown in SEQ ID NO: 1 as the amino acid sequence of a H chain variable region (VH), and having the amino acid sequence shown in SEQ ID NO: 2 as the amino acid sequence of a L chain variable region (VL); and (b) an antibody having the amino acid sequence shown in SEQ ID NO: 3 as the amino acid sequence of a H chain variable region (VH), and having the amino acid sequence shown in SEQ ID NO: 4 as the amino acid sequence of a L chain variable region (VL).

Abstract: The present invention relates to monoclonal antibody 0.5.beta. which binds to an epitope located within the region of amino acids 308-331 of HTLVIIIB gp120 and is capable of substantially neutralising the activity of human immunodeficiency viruses, to a hybridoma which produces the 0.5.beta. antibody, to processes for preparing them and to compositions containing an effective amount of the antibody.

Abstract: A murine monoclonal antibody which specifically binds to a glycoprotein antigen having a molecular weight of about 12.times.10.sup.4 daltons (gp120) present in the envelope of human T-lymphotropic virus III.sub.MN (HTLV-III.sub.MN) and capable of neutralizing the HTLV-III.sub.MN as determined by in vitro inhibition of syncytium formation but does not bind to other HTLV-III strains, or antigen-binding fragments, which is useful for prophylaxis, treatment and diagnosis of AIDS.

Abstract: The present invention is directed to an antibody or fragment thereof, modified with a toxic substance capable of substantially inhibiting the growth of human cells infected with viruses, which is prepared by conjugating a substance capable of chemically and/or physically inducing cytotoxicity against human cells infected with HIV with an antibody or fragment thereof capable of specifically reacting with at least one antigen of said viruses, by using a pharmacologically inert substance as a carrier. The antibodies according to the present invention may be used, for example, in the diagnosis, prevention and curing of chronic disorders induced by viral infections, e.g. AIDS and leukemia, since they are not only capable of inhibiting the growth of the virus-producing cells and capable of killing such cells but also are capable of neutralizing the viruses without inhibiting the growth of uninfected cells.

Abstract: An auto-focusing system includes a focus condition detector which detects focus condition based on the infrared light. A data producer is provided for producing a deflection signal indicating a difference between an image forming distance for the infrared light and that for the visible light, due to aberration. In accordance with the detected focus condition and deflection signal, an objective lens is shifted to a position for properly focusing an image of visible light on an image forming plane.

Abstract: In an interchangeable lens including an optical system adjustable for focusing and adapted to be detachably mounted on a camera body which is provided with focus detection means for detecting an amount of defocus of an object image formed by the optical system, and drive means for driving the optical system for the focus adjustment thereof in accordance with the detected amount of defocus. The interchangeable lens comprises, inter alia, a code plate for producing a plurality of digital photographic distance signals representing given discrete photographic distances of the optical system in accordance with the adjustment of the optical system for focusing.

Abstract: A contralight compensation exposure control system which determines as a contralight condition and fires a strobe when there is a difference between the output of a partial light measuring means for measuring the brightness of a portion of a scene to be photographed i.e. the brightness of the main object such as a person, and the output of an average light measuring means for measuring the brightness of comparatively large area of the scene i.e. the brightness of the subordinate object such as the background of the main object. The control circuit of the system inhibits the strobe firing and actuates an exposure compensation means to shift the controlled exposure to the overexposure side when a detecting means detect uncompletion of charging of the main capacitor for firing the strobe even if the contralight condition is detected.

Abstract: The present invention is an immortalized B-cell line which produces a human monoclonal antibody IgG-Kk which specifically binds to the envelope antigen of human T-cell leukemia virus Type 1 (HTLV-I). This monoclonal antibody is useful as a diagnostic reagent by binding to the antigen specifically expressed on the surface of HTLV producing cells. Furthermore, this monoclonal antibody is useful as a therapeutic reagent, in combination with complement, for the lysis of HTLV-1 producing cells.

Abstract: An auto-focusing system includes a focus condition detector which detects the focus condition based on infrared light. A data producer is provided for producing a deflection signal indicating the difference between an image forming distance for infrared light and that for visible light, due to aberration. In accordance with the detected focus condition and deflection signal, an objective lens is shifted to a position for properly focusing an image of visible light on an image forming plane.

Abstract: An active focus detecting device for use in a camera is provided and includes emitting light that is polarized, and collimated so that the light forms a light bundle which will pass near the optical axis of the objective lens, and then will be projected in a diverging light path after having been focused by the objective lens towards the object. A polarization component is provided for receiving the returning light and directing a component of that light towards a detector for determining a focusing condition.

Abstract: A camera in which a plurality of photographic data are input by manual key operations is made easily operable with less possibility of erroneous data input by inadvertent key operations. The data to be input are classified into first and second groups in accordance with the relevancy of the respective data or the frequency of changing of the respective data during photographing operations. In one embodiment, first and second photographic data setting sections are separately provided at different positions and input keys included in the first data setting section are used for the input of the first group data whereas input keys included in the second data setting section are used for the input of the second group data. In another embodiment, input keys common to the first and second group data setting are included in a single photographic data setting section.