Abstract: A method for treating or preventing a disease involving autotaxin including administering a carboxylic acid compound of formula (1) or a pharmacologically acceptable salt thereof to a patient in need thereof.

Abstract: Provided is a compound superior in an ATX inhibitory action and useful for the prophylaxis or treatment of diseases involving ATX. A carboxylic acid compound represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein each symbol is as defined in the SPECIFICATION.

Abstract: Provided is a compound superior in an ATX inhibitory action and useful for the prophylaxis or treatment of diseases involving ATX. A carboxylic acid compound represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein each symbol is as defined in the SPECIFICATION.

Abstract: The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, which has a superior peripheral blood lymphocyte decreasing action, and is useful for the treatment or prophylaxis of autoimmune diseases; prophylaxis or suppression of resistance or acute rejection or chronic rejection of transplantation of organ or tissue; treatment or prophylaxis of graft-versus-host (GvH) disease due to bone marrow transplantation; or treatment or prophylaxis of allergic diseases.

Abstract: The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, which has a superior peripheral blood lymphocyte decreasing action, and is useful for the treatment or prophylaxis of autoimmune diseases; prophylaxis or suppression of resistance or acute rejection or chronic rejection of transplantation of organ or tissue; treatment or prophylaxis of graft-versus-host (GvH) disease due to bone marrow transplantation; or treatment or prophylaxis of allergic diseases.

Abstract: (2S)-[4-(Carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide hydrobromide and a crystal thereof, which resist easy weight change caused by vapor sorption as compared to a free form, and are superior as drug substances of pharmaceutical products, and a production intermediate therefor are provided.

Abstract: A compound represented by the formula (1) wherein ring A is aryl optionally having substituent(s) and the like; ring B is arylene optionally having substituent(s) and the like; m=0-2; n=1-5; X is a bond and the like; Y is a bond and the like; and Z is hydrogen atom and the like or a pharmaceutically acceptable salt thereof, and a hydrate or solvate thereof have affinity for CCR3, and can be pharmaceutical products for the treatment and/or prophylaxis of immune or inflammatory diseases.

Abstract: (2S)-[4-(Carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide hydrobromide and a crystal thereof, which resist easy weight change caused by vapor sorption as compared to a free form, and are superior as drug substances of pharmaceutical products, and a production intermediate therefor are provided.

Abstract: A compound represented by the formula (1) wherein ring A is aryl optionally having substituent(s) and the like; ring B is arylene optionally having substituent(s) and the like; m=0-2; n=1-5; X is a bond and the like; Y is a bond and the like; and Z is hydrogen atom and the like or a pharmaceutically acceptable salt thereof, and a hydrate or solvate thereof have affinity for CCR3, and can be pharmaceutical products for the treatment and/or prophylaxis of immune or inflammatory diseases.

Abstract: An apparatus of the present invention is a magnetic recording/reproduction apparatus for pulling out a magnetic tape from a tape cassette, forming a predetermined tape drive system with a group of tape guide posts while winding the magnetic tape around a rotary head cylinder, having a rotary head, for a predetermined arc, so as to perform recording/reproduction of the magnetic tape. The group of tape guide posts include at least one inclination adjustment tape guide post whose inclination angle can be adjusted.

Abstract: A loading mechanism of a video tape recorder is provided which reduces the thickness of the mechanism for guiding a loading boat along a loading guide. Also, a loading post driving device for a magnetic recording/playback apparatus is provided which can prevent the rotary head cylinder from being damaged or interfered with in its rotation. Furthermore, a loading post holding device which can considerably reduce the height of the device is provided. Additionally, an arrangement of a loading ring guide is provided for loading post driving device to reduce the number of parts used and improve the assembling efficiency of the device.

Abstract: A loading mechanism of a video tape recorder is provided which reduces the thickness of the mechanism for guiding a loading boat along a loading guide. Also, a loading post driving device for a magnetic recording/playback apparatus is provided which can prevent the rotary head cylinder from being damaged or interfered with in its rotation. Furthermore, a loading post holding device which can considerably reduce the height of the device is provided. Additionally, an arrangement of a loading ring guide is provided for a loading post driving device to reduce the number of parts used and improve the assembling efficiency of the device.

Abstract: A loading mechanism of a video tape recorder is provided which reduces the thickness of the mechanism for guiding a loading boat along a loading guide. Also, a loading post driving device for a magnetic recording/playback apparatus is provided which can prevent the rotary head cylinder from being damaged or interfered with in its rotation. Furthermore, a loading post holding device which can considerably reduce the height of the device is provided. Additionally, an arrangement of a loading ring guide is provided for a loading post driving device to reduce the number of parts used and improve the assembling efficiency of the device.

Abstract: A video recording and playback device with a built-in video camera includes an outer case having the same profile as that of a tape cassette that can be inserted into an exiting stationary video tape recorder.

Abstract: Disclosed is a tape loading device of a video tape recorder provided with an inclined video head cylinder and a capstan. The tape loading device includes a first guide member for feeding a tape on a horizontal path to the inclined video head cylinder, a second guide member for taking out the tape from the video head cylinder, and a third guide member for guiding the tape having passed the second guide member. The first, second and third guide members move along the video head cylinder and are in contact with the internal surface of the tape during the tape loading operation. The tape loading device further includes a fourth guide member for restoring the tape from an inclined path to a horizontal path during the tape loading operation by contacting the external surface of the tape, and an auxiliary inclined member for moving the tape inwardly during the tape loading operation so that the tape may be restored from an inclined path to a horizontal path.