Abstract: The present invention relates to a use of compounds having TRPV4 inhibitory activity or pharmaceutically acceptable salts thereof, or pharmaceutical compositions containing them for the manufacture of a medicament for preventing or treating a retinal disease accompanied with blood flow disorder or cell disorder. It also relates to a method for preventing or treating the disease, wherein the method comprises administering the compounds or the pharmaceutical compositions containing them to humans or animals. The compounds, the pharmaceutically acceptable salts thereof, or the pharmaceutical compositions containing them may be used in combination with one or more second active agents. The present invention relates to a pharmaceutical composition and a kit containing a compound having TRPV4 inhibitory activity or a pharmaceutically acceptable salt thereof, which is used for preventing or treating the disease.

Abstract: A pneumatic booster capable of suppressing braking force from becoming excessive relative to an input force applied to a brake pedal. A valve mechanism (13) includes a poppet valve (14) movably attached to a small-diameter cylindrical portion of a valve body (6), an annular abutment portion formed on a plunger body of a plunger (20) to bring a variable-pressure chamber B into and out of communication with the atmosphere by unseating from and seating on the poppet valve, respectively, a movable seat member (29) movably guided by the valve body to bring a negative-pressure chamber A and the variable-pressure chamber B into and out of communication with each other, and a transmitting member (31) having one end abutting against the movable seat member and the other end disposed to surround a stepped piston of the plunger so as to be abuttable against a reaction disk (27).

Abstract: A pulverized coal burner for an oxyfuel combustion boiler which attains uniform combustion from a pulverized coal burner and which constrains a temperature rise of an oxygen injection nozzle is provided. The burner includes burner inner and outer cylinders arranged to penetrate a wind box and come close to a throat portion. A pulverized coal feed passage is provided between the burner inner and outer cylinders. A plurality of oxygen injection devices are arranged outwardly of the burner outer cylinder so as to directly feed oxygen ahead of the burner outer cylinder.

Abstract: A pneumatic booster (40) disposed between a brake pedal (5) and a master cylinder (7) includes a cylindrical member (60) provided on an outer circumferential side of an output rod (58). A seal member (62) seals between an outer circumferential side of the cylindrical member and a cylindrical portion of a front shell, and an O-ring seals between the cylindrical member and the output rod. The cylindrical member causes a differential pressure between a negative pressure chamber (A) and an atmosphere chamber (C) to be applied to a valve body (46). One axial side of the cylindrical member is configured to cause an atmosphere pressure to be applied to the valve body by abutting against a cylindrical protruding portion of the valve body, thereby pushing the valve body with the aid of the differential pressure in the direction as a biasing direction of a return spring.

Abstract: The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S) blocker such as NaV1.3 and NaV1.7, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved.

Abstract: Provided are a method and an apparatus of controlling an oxygen supply in an oxyfuel combustion boiler capable of attaining stable oxyfuel combustion even when properties of coal are changed. A boiler-brought-in oxygen density is obtained when coal with a fuel ratio measured by fuel measuring means 39 is burned stably with oxygen in a boiler 4 so that a relationship between the fuel ratio and/or carbon content of the coal and the boiler-brought-in oxygen density is obtained and inputted in advance into the controller. When the coal is changed to the new kind of coal, a total amount of gases recirculated is regulated such that a boiler-brought-in oxygen density becomes accordance with a fuel ratio and/or a carbon content which is measured in advance for the new kind of coal.

Abstract: A gasified-gas generation system includes: a combustor that heats a fluid medium; a gasifier into which the fluid medium heated by the combustor is introduced and which gasifies a gasification material with heat of the fluid medium so as to generate a gasified gas; and a cooling mechanism that cools the fluid medium that flows between the gasifier and the combustor. The fluid medium circulates between the combustor and the gasifier. The fluid medium and a residue of the gasification material are introduced from the gasifier into the combustor, and the combustor burns the residue to heat the fluid medium.

Abstract: The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S) blocker such as NaV1.3 and NaV1.7, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved.

Abstract: The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S) blockers such as NaV1.3 and NaV1.7, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved.

Abstract: A pneumatic booster capable of suppressing braking force from becoming excessive relative to an input force applied to a brake pedal. A valve mechanism (13) includes a poppet valve (14) movably attached to a small-diameter cylindrical portion of a valve body (6), an annular abutment portion formed on a plunger body of a plunger (20) to bring a variable-pressure chamber B into and out of communication with the atmosphere by unseating from and seating on the poppet valve, respectively, a movable seat member (29) movably guided by the valve body to bring a negative-pressure chamber A and the variable-pressure chamber B into and out of communication with each other, and a transmitting member (31) having one end abutting against the movable seat member and the other end disposed to surround a stepped piston of the plunger so as to be abuttable against a reaction disk (27).

Abstract: The present invention relates to acyl piperazine derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

Abstract: A pneumatic booster (40) disposed between a brake pedal (5) and a master cylinder (7) includes a cylindrical member (60) provided on an outer circumferential side of an output rod (58). A seal member (62) seals between an outer circumferential side of the cylindrical member and a cylindrical portion of a front shell, and an O-ring seals between the cylindrical member and the output rod. The cylindrical member causes a differential pressure between a negative pressure chamber (A) and an atmosphere chamber (C) to be applied to a valve body (46). One axial side of the cylindrical member is configured to cause an atmosphere pressure to be applied to the valve body by abutting against a cylindrical protruding portion of the valve body, thereby pushing the valve body with the aid of the differential pressure in the direction as a biasing direction of a return spring.

Abstract: In an oxygen mixer for an oxygen combustion boiler, circulating exhaust gas heated in a rotary preheater is mixed with oxygen. Resultant mixed gas is guided to a boiler furnace through a combustion gas duct having bends. At the bend closest to the rotary preheater in the combustion gas duct, an oxygen injection nozzle is arranged to have a plurality of injection ports for injection of oxygen into circulating exhaust gas.

Abstract: In an apparatus of controlling an exhaust gas in an oxyfuel combustion boiler having the boiler 4 provided with burners 6 and a two-stage combustion port 7, a primary recirculation line 12 through which pulverized coal obtained by a mill 3 is fed to the burners 6 of the boiler 4 by the primary recirculating exhaust gas, a secondary recirculation line 14 through which another portion of the exhaust gas in recirculation is fed to a wind box 5 of the boiler 4, an oxygen producer 23, a direct supply line 25 through which a portion of oxygen produced by the oxygen producer 23 is directly fed to the burner 6 and a secondary oxygen mixing line 24 through which another portion of oxygen produced by the oxygen producer 23 is fed to the secondary recirculation line 14, the apparatus comprises an oxygen supply line 26 through which oxygen is fed to the two-stage combustion port of the boiler 4 and a flow rate regulator 20, 27 in the oxygen supply line for adjusting oxygen density.

Abstract: Provided are a method and an apparatus of controlling a flow rate of a primary recirculating exhaust gas in an oxyfuel combustion boiler, capable of realizing a stable combustion by a burner in oxyfuel combustion. Weight ratio of flow rate of primary recirculating exhaust gas [ton/h] to amount of pulverized coal from a mill [ton/h] is defined as G/C, and the flow rate of primary recirculating exhaust gas is controlled so that the G/C falls within a given range.

Abstract: Provided are a method and an apparatus of controlling exhaust gas in an oxyfuel combustion boiler which can attain stable combustion of the boiler while an amount of unburned combustibles and a NOx density in exhaust gas are maintained in their allowable ranges. A rate of supply of directly supplied oxygen to burners 6 to a total amount of oxygen produced by an air separation unit 18 is regulated in an operating range where the NOx density in the exhaust gas is below a NOx limit value and the amount of unburned combustibles in the exhaust gas is blow an unburned combustible limit value to thereby attain stable combustion of the oxyfuel combustion boiler.

Abstract: Provided are fuel feed means 3, an air separation unit 6 air feed means 7, a combustion furnace 11 with a burner 9 for combustion, an exhaust gas line 14 for leading an exhaust gas from the combustion furnace 11 to outside of the combustion furnace 11, exhaust gas treatment means 20a and 20b included in the exhaust gas line 14, and a recirculation line 15 for circulating a portion of the exhaust gas at least exhaust gas treatment means 20a and 20b for recirculation of a portion of the exhaust gas at least dust-removed by the exhaust gas treatment means 20a and 20b to the burner. Further provided are exhaust gas capture means 18 for taking out carbon dioxide gas from a remaining non-recirculating exhaust gas, and carbon dioxide gas feed means 33, 40 and 46 for introducing carbon dioxide gas to equipments 10, 20a and 20b of the oxyfuel combustion boiler facility.

Abstract: The present invention relates to acyl piperazine derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

Abstract: In an oxygen mixer for an oxygen combustion boiler, circulating exhaust gas heated in a rotary preheater is mixed with oxygen. Resultant mixed gas is guided to a boiler furnace through a combustion gas duct having bends. At the bend closest to the rotary preheater in the combustion gas duct, an oxygen injection nozzle is arranged to have a plurality of injection ports for injection of oxygen into circulating exhaust gas.

Abstract: The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S) blockers such as Nav1.3 and Nav1.7, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved.