Patents by Inventor Shyam B. Karki

Shyam B. Karki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Active salt forms with tyrosine kinase activity
    Publication number: 20040023978
    Abstract: The present invention relates to orally active salt forms of the mesylate salt of 4-[2-(5-cyano-thiazol-2-ylamino)-pyridin-4-ylmethyl]-piperazine-1-carboxylic acid methylamide which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, retinal ischemia, macular edema, inflammatory diseases, and the like in mammals.
    Type: Application
    Filed: June 26, 2003
    Publication date: February 5, 2004
    Inventors: Yu Ren, Shyam B. Karki, Matthew M. Zhao, Mark T. Bilodeau
  • Orally active salts with tyrosine kinase activity
    Publication number: 20040002501
    Abstract: The present invention relates to orally active salts of compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angio-genesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
    Type: Application
    Filed: April 10, 2003
    Publication date: January 1, 2004
    Inventors: Mark E. Fraley, Shyam B. Karki, Yuntae Kim
  • Orally active salts with tyrosine kinase activity
    Patent number: 6656942
    Abstract: The present invention relates to orally active salts of compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angio-genesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
    Type: Grant
    Filed: October 17, 2001
    Date of Patent: December 2, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Mark E. Fraley, Shyam B. Karki, Yuntae Kim
  • Orally active salts with tyrosine kinase activity
    Publication number: 20020072526
    Abstract: The present invention relates to orally active salts of compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angio-genesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
    Type: Application
    Filed: October 17, 2001
    Publication date: June 13, 2002
    Inventors: Mark E. Fraley, Shyam B. Karki, Yuntae Kim
  • Salt form of a conjugate useful in the treatment of prostate cancer
    Patent number: 6355611
    Abstract: The present invention is directed to the sodium salt of formula 5: which may be useful in the treatment of prostate cancer and benign prostatic hyperplasia. Also described are lyophilized formulations that comprise the sodium salt 5 or the corresponding free acid.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: March 12, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Shyam B. Karki, Mark Cameron, David R. Lieberman, Joseph E. Lynch, Michael A. Robbins, Yao-Jun Shi, Örn Almarsson, Michael J. Kaufman, Maneesh J. Nerurkar