Abstract: A topical formulation includes a water-soluble ingredient and an oil-soluble ingredient and includes a combination of water, a rheology modifier, and a water miscible organic solvent to stabilize the composition.

Abstract: This invention relates to certain extracts of Artemisia annua plant, both in their crude and refined forms, and certain refined forms of Artemisia annua plant extracts composed substantially of Artemisinin and its analogs, which are chemically classified as sesquiterpenes with an endo-peroxide group [FIG. 1]. These are suitable for compositions comprising topical application, and for the treatment or improvement of skin condition including acne, rosacea, topical wounds, age spots, wrinkles, excess facial oil, and darkened skin.

Abstract: The present invention provides treatment of infants and incontinent adults related to diaper rash, also known as diaper dermatitis, by the application of divalent metal complexes of zeolites, such as zinc zeolite, and compositions thereof.

Abstract: The present invention discloses safety and efficacy enhancement of sunscreens with certain heterocyclic base complexes of manganese via urocanate pathway modulation. The present invention also discloses a method for topical application of said complexes, which causes the reduction of topical peroxide including hydrogen peroxide, the reduction of topical inflammation including sunburn, increased sun protection of skin, the reduction of skin wrinkles, comprehensive protection from UVA, UVB, and UVC, and reduction of radiation-initiated inflammation.

Abstract: The present invention discloses compositions and methodology based on certain natural lignans that provide treatment of topical discomforts and ailments including sunburn, radiation burn, thermal burn and blisters, diaper rash, shaving burn, wound, venous cannulation, acne, darkened skin pigmentation, skin wrinkles, dandruff, and hair loss; said treatment having achieved via topical inhibition of Fatty Acid Desaturases.

Abstract: The present invention discloses certain complexes of anionic zeolites with active oxygen donor agents, such as organic or inorganic peroxides, and methods and compositions based on said complexes for skin whitening.

Abstract: This invention relates to the preparation of conjugates of sucrose and certain polyhydroxy lactones. Such conjugates have shown surprising and unexpected adhesive properties, which are useful for certain cosmetic applications such as dermabrasion, topical exfoliation, age spot removal, wart removal, and hair removal (depilation).

Abstract: This invention relates to Schiff's bases derived from amino acids and hydroxyaryl alkyl ketones, or a plant extract containing the same, having general chemical structure in FIG. 1 for topical application. This invention also relates to certain metal complex of said Schiff's bases, which have a crown-like appearance in their three-dimensional chemical structure, as in FIG. 2. The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase. These are further suitable for multifunctional topical methods for skin whitening, skin wrinkles reduction, skin antiaging, collagen synthesis, acne control, hair loss prevention, hair graying control, and facial oil control.

Abstract: This invention relates to certain divalent and polyvalent d-orbital metals of first transition series of the Periodic Table of Elements, from Group IV to Group VI, and including Molybdenum, complexed concurrently with an amino acid, or an equivalent of an amino acid, and a hydroxy acid in a novel spirocyclic bidentate chemical complex form (FIG. 1). Upon topical application said metal complexes undergo enhanced skin penetration without causing skin irritation. The said metal complexes are useful for topical conditions that include dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, age spots, dark circles around eyes, skin pigmentation, topical inflammation, liver spots, pigmented spots, wrinkles, blemishes, skin lines, oily skin, acne, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, disturbed keratinization, dandruff, bacterial infection, fungal infection, wound healing, body odor, and skin changes associated with aging.

Abstract: Cosmetic hair removal (depilatory) compositions that provide complete hair removal in a single step and easy clean-up with water are disclosed. These viscous compositions are made of a mixture of a water soluble hair binding agent, a water soluble cross-linking agent for the hair binding agent, and a water soluble crystallization inhibitor agent, whereby the cross-linking of the hair binding agent by the cross-linking agent results in water washable hair binding compositions that do not crystallize during their use or storage.

Abstract: The present invention discloses compositions based on certain furostanol saponins and sapogenins that reduce sebum production. These compounds are useful for the reduction of excess sebum associated with dermatological disorders such as acne, dandruff, and body malodor.

Abstract: A depilatory composition that can be applied in liquid form on the surface of the skin, and which is removable by peeling away from the surface of the skin after setting to a pliable film, said composition consisting essentially of (i) a pliable film forming agent, (ii) a hair binding agent, and (iii) a hydroxylic matrix forming agent, and, wherein the relative amounts of said pliable film forming agent, said hair binding agent, and said hydroxylic matrix forming agent are such that said composition upon first heating to a liquid state, then applying to skin transforms to a pliable film, which is capable of catching hairs without adhering to the skin and being removable by peeling away from the skin along with the hairs caught in the pliable film.

Abstract: This invention relates to the use of Hydroxycitric acid and its derivatives in cosmetic and pharmaceutical compositions for reducing body malodor.

Abstract: This invention provides certain ubiquitinylation modulating molecular chaperone compounds and their use in the prevention and/or treatment of ailments associated with the dysfunction of ubiquitin-proteasome pathway, including inflammation, wound healing, skin aging, body enzyme dysfunction, neurodegenerative disorders, and cellular apoptosis.

Abstract: A method for skin improvement, comprising the application of a mask composed of two different fluid components, wherein the first component is adapted to be applied to contact skin, and second component is adapted to be applied to contact the first component, and whereby first and second components chemically react with each other to form a new gel-like component that adapts to the shape of skin as a continuous film, and which is removed from skin as a continuous gel-like film upon being pulled away from skin, and which also removes skin wrinkles, skin blemishes, and skin discoloration as the continuous film is pulled away from skin.

Abstract: The present invention relates to a method for topical delivery of trace metals for the modulation of certain metalloenzymes. The method of topical delivery of the present invention comprises; (i) mixing of a trace metal salt of a phosphorylated nitrogen heterocyclic base complexed with a chelating agent [FIG. 1], and (ii) a carrier, and (iii) topical application of said mixture. The modulation of metalloenzymes such as Superoxide Dismutase, Elastase, Tyrosinase, Matrix metalloproteases, and Ubiquitin-Proteasome pathway by the methods of the present invention is useful for providing anti-inflammatory, skin whitening, wrinkles reduction, skin aging control, cellular antioxidant, acne control, hair growth modulation, and skin damage control benefits.

Abstract: This invention relates to concurrent enhancement of skin penetration of certain organic nitrogen heterocyclic base active agents and certain organic acid active agents, especially organic hydroxy acids. This concurrent enhancement of skin penetration also provides enhanced bioavailability of both organic nitrogen heterocyclic base active agent and organic hydroxy acid active agent. The organic nitrogen heterocyclic base active agents and organic hydroxy acid active agents are first combined to form an ion-pair complex, which includes an in-situ mixing process, and said ion-pair complex is applied topically, whereupon said ion-pair complex undergoes enhanced skin penetration and upon reaching uppermost living part of skin and having reached therein the physiological pH of 7.4, said ion-pair complex dissociates to release its constituent organic nitrogen heterocyclic base active agent and said organic acid active agent in a bioavailable form.

Abstract: The present invention discloses the application of cage complexes of zeolites for topical controlled delivery of organic cosmetic and pharmaceutical active agents. The treatment and protection of skin surface requires that certain organic cosmetic and pharmaceutical active agents be delivered slowly and allowed to remain on skin surface for extended periods. Zeolite cage complexes of the present invention do not absorb into skin and affect a controlled release of cosmetic and pharmaceutical agents by an osmotic nano-diffusion method upon contact with water. Topical treatments that includes skin aging, anti-wrinkle, antioxidants, skin whitening, acne, rosacea, sun screens, UV blocks, anesthetics, skin soothers, anti-irritants, anti-inflammatory agents, vitamins, hormones, and such that require a controlled release of active agents are now practical by the present invention.

Abstract: This invention relates to topical compositions containing esters of hydroxy acids and their application in the deep-penetration delivery of beneficial cosmetic and pharmaceutical agents.

Abstract: This invention relates to compounds that are selective inhibitors of Matrix Metalloprotease (also known as Matrix Metalloproteinase, MMP), to cosmetic and pharmaceutical compositions containing them, and to their use in the prevention and/or treatment of ailments associated with MMP, including inflammation, wound healing, skin aging, skin tone discoloration, body odor, oral cavity odor, rosacea, acne, and hair growth modulation.