Abstract: Some implementations include methods for replacing advertisements that have been inserted into a manifest associated with live streaming and may include receiving a request for a manifest from a player to enable a user to watch a live stream of an event. The request may be received at a first time when the live stream is already in progress. The manifest may be generated to include content fragments associated with the live event and advertisements based on first set of selection criteria. The manifest may be sent to the player to enable the user to watch the live stream. A seek back request may be received from the player to enable the user to watch the live stream at a second time earlier than the first time. The manifest may be updated to replace at least one advertisement with a replacement advertisement selected based on second set of selection criteria.

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize or partially agonize or antagonize) glucagon-like peptide-1 receptor (“GLP-1R”) and/or the gastric inhibitory polypeptide receptor (“GIPR”). The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which modulation (e.g., agonism, partial agonism or antagonism) of GLP-1R and/or GIPR activities is beneficial for the treatment or prevention of the underlying pathology and/or symptoms and/or progression of the disease, disorder, or condition. In some embodiments, the modulation results in an enhancement of (e.g., an increase in) existing levels (e.g., normal or below normal levels) of GLP-1R and/or GIPR activity (e.g., signaling). In some embodiments, the chemical entities described herein further modulate (e.g.

Abstract: An exemplary embodiment of the present disclosure provides a wireless network system comprising a mobile access point, a wireless device, and an actuator. The actuator further configured to move the mobile access point to a position having an improved line of sight condition between the wireless device and the mobile access point.

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt) that modulate (e.g., agonize or partially agonize or antagonize) glucagon-like peptide-1 receptor (“GLP-1R”) and/or the gastric inhibitory polypeptide receptor (“GIPR”). The chemical entities are useful, e.g., for treating a disease, disorder, or condition in which modulation (e.g., agonism, partial agonism or antagonism) of GLP-1R and/or GIPR activities is beneficial for the treatment or prevention of the underlying pathology and/or symptoms and/or progression of the disease, disorder, or condition. In some embodiments, modulation results in enhancement of (e.g., increases) existing levels (e.g., normal or below normal levels) of GLP-1R and/or GIPR activity (e.g., signaling). In some embodiments, the chemical entities described herein further modulate (e.g., attenuate, uncouple) ?-arrestin signaling relative to what is observed with the native ligand.

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize or partially agonize or antagonize) glucagon?like peptide?1 receptor (“GLP?1R”) and/or the gastric inhibitory polypeptide receptor (“GIPR”). The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which modulation (e.g., agonism, partial agonism or antagonism) of GLP?1R and/or GIPR activities is beneficial for the treatment or prevention of the underlying pathology and/or symptoms and/or progression of the disease, disorder, or condition. In some embodiments, the modulation results in an enhancement of (e.g., an increase in) existing levels (e.g., normal or below normal levels) of GLP?1R and/or GIPR activity (e.g., signaling). In some embodiments, the chemical entities described herein further modulate (e.g.

Abstract: A network device includes a first agent programmed to provide a functionality of the network device. The network device also includes a message bus, distinct from the first agent, that identifies an update associated with the first agent, the update includes differential state information based, at least in part, on a state of the first agent, the state of the first agent is stored in a data structure exclusively managed by the first agent; in response to identifying the update: identifies a second agent that is subscribed to the first agent; and performs an action set to provide the second agent with access to the update.

Abstract: Methods and apparatus are described for facilitating the client-side caching of media content based on one or more properties of the media content. Information relating to the cacheability of different types of content is communicated to the media player on a client device in the manifest or playlist employed by the media player to request fragments of the media content. The media player uses this information to make decisions about how to cache the corresponding content.

Abstract: A network device includes a first agent programmed to provide a functionality of the network device. The network device also includes a message bus, distinct from the first agent, that identifies an update associated with the first agent, the update includes differential state information based, at least in part, on a state of the first agent, the state of the first agent is stored in a data structure exclusively managed by the first agent; in response to identifying the update: identifies a second agent that is subscribed to the first agent; and performs an action set to provide the second agent with access to the update.

Abstract: A network device includes a storage and a message bus. The storage stores subscription information. The message bus distributes state information associated with a first agent to at least two agents based on the subscription information. The message bus is distinct from the first agent. The state information is stored in a data structure exclusively managed by the first agent. The message bus, after distributing the state information, makes a determination that a connection to one of the at least two agents has been closed; and performs, based on the determination, an action set to prevent attempts to distribute future state information to the one of the at least two agents.

Abstract: Provided herein are compounds such as the compounds having the structure of Formula (XI) and methods of using the same, such as methods of inhibiting kinases.

Abstract: Methods of inhibiting kinases using kinase inhibitors having olefin moieties are disclosed.

Abstract: Provided herein are compositions including diastereomers in substantially diastereomerically pure form and enantiomers in substantially enantiomerically pure form, and processes for preparing them and converting them to metyrosine.

Abstract: Methods of inhibiting kinases using kinase inhibitors having olefin moieties are disclosed.

Abstract: Provided herein are compositions including diastereomers in substantially diastereomerically pure form and enantiomers in substantially enantiomerically pure form, and processes for preparing them and converting them to metyrosine.

Abstract: Provided herein are kinase inhibiting compounds and methods of using the same.

Abstract: Provided herein are compositions including diastereomers in substantially diastereomerically pure form and enantiomers in substantially enantiomerically pure form, and processes for preparing them and converting them to metyrosine.

Abstract: Methods of inhibiting kinases using kinase inhibitors having olefin moieties are disclosed.

Abstract: Provided herein are compositions including diastereomers in substantially diastereomerically pure form and enantiomers in substantially enantiomerically pure form, and processes for preparing them and converting them to metyrosine.

Abstract: A method for decoding an input bit stream encoded using Huffman encoding generates a lookup table using a standard Huffman code book. Thereafter, at least three bits are extracted from the input bit stream. The at least three bits extracted are used to traverse the lookup table. Subsequently, a data set corresponding to a Huffman code word is accessed, thereby decoding the input bit stream.