Abstract: Some embodiments provide a two-tier DNS (Domain Name System) service for processing DNS requests. In some embodiments, the two-tier DNS service deploys first and second tiers of service machines, with the second-tier having several groups of service machines each of which is configured to resolve DNS requests for a different set of domain names than the other second-tier group(s). Each service machine in the first-tier is configured to identify the second-tier group responsible for each particular DNS request that the service machine receives for each particular domain name, and to forward the particular DNS request to the second-tier group that it identifies for the particular DNS request. The first-tier DNS service in some embodiments has only one group of service machines. Each first or second service machine group in some embodiments can have one or more service machines, and can be scaled up or down to add or remove service machines to the group (e.g., through an active/active layer 3 scaleout with BGP).

Abstract: A composition of chlorogenic acids and method of its use and manufacture in the treatment of metabolic disorders. The composition can be obtained from sunflower seed extract, including Helianthus annulus seeds.

Abstract: The invention provides a polyphenolic composition and method for its use and manufacture in the treatment of metabolic disorders. The active agents of the composition can include flavonoids and anthocyanins. The active agents can be obtained from rose petal extract, including Rosa multiflora rose petal extract. The composition finds use in the treatment of obesity and complications associated with obesity.

Abstract: The invention provides a composition and method for treating prostate disorders. The composition can be formulated to provide a saw palmetto oil having about 3% w/w ?-sitosterol.

Abstract: Some embodiments provide a two-tier DNS (Domain Name System) service for processing DNS requests. In some embodiments, the two-tier DNS service deploys first and second tiers of service machines, with the second-tier having several groups of service machines each of which is configured to resolve DNS requests for a different set of domain names than the other second-tier group(s). Each service machine in the first-tier is configured to identify the second-tier group responsible for each particular DNS request that the service machine receives for each particular domain name, and to forward the particular DNS request to the second-tier group that it identifies for the particular DNS request. The first-tier DNS service in some embodiments has only one group of service machines. Each first or second service machine group in some embodiments can have one or more service machines, and can be scaled up or down to add or remove service machines to the group (e.g., through an active/active layer 3 scaleout with BGP).

Abstract: The invention provides compositions comprising chlorogenic acid and methods for their use and manufacture in the treatment of Alzheimer's disease. The compositions can be formulated from botanical sources of chlorogenic acid including sunflower seed extract.

Abstract: Disclosed is a composition comprising bisacurone. The composition finds use in treating the skin, including skin whitening applications. The composition can be obtained from an extract of turmeric rhizome.

Abstract: The invention provides a polyphenolic composition and method for its use and manufacture in the treatment of metabolic disorders. The active agents of the composition can include flavonoids and anthocyanins. The active agents can be obtained from rose petal extract, including Rosa multiflora rose petal extract. The composition finds use in the treatment of obesity and complications associated with obesity.

Abstract: A glass manufacturing apparatus includes a forming apparatus defining a travel path extending in a travel direction. The forming apparatus conveys a ribbon of glass-forming material along the travel path in the travel direction of the forming apparatus. The glass manufacturing apparatus includes a cooling tube extending substantially parallel to the travel path and extending across the travel direction. The cooling tube includes a plurality of orifices spaced apart along the cooling tube and facing the travel path. Methods of manufacturing glass can comprise flowing a coolant from an outlet of a conduit in a direction toward a target location of a flowing ribbon of molten material. Methods can also include changing a phase of the coolant while the coolant is flowing towards the target location. The change in phase can cool the target location.

Abstract: The invention provides a liposome with integrated dietary fiber. The inventive liposome has improved stability, strength, encapsulation and delivery properties for hydrophobic and hydrophilic agents. The integrated dietary fiber permits the liposome to be dried for enhanced storage stability without compromising liposome integrity, strength, shape or surface smoothness due to the loss of water. Methods of making and using the inventive liposome for the delivery of active agents are also contemplated by the invention.

Abstract: A circuit for slew rate detection and phase control in a multi-phase converter is provided. The circuit includes a first comparator configured to trigger when an output voltage of the multi-phase converter falls to a first output voltage level threshold value. The circuit further includes a second comparator configured to trigger when the output voltage falls to a second output voltage level threshold value which is lower than the first output voltage level threshold value. The circuit further includes a timer configured to start to run for a predefined time window, when the output voltage of the multi-phase converter falls below first output voltage level threshold value.

Abstract: Some embodiments provide a two-tier DNS (Domain Name System) service for processing DNS requests. In some embodiments, the two-tier DNS service deploys first and second tiers of service machines, with the second-tier having several groups of service machines each of which is configured to resolve DNS requests for a different set of domain names than the other second-tier group(s). Each service machine in the first-tier is configured to identify the second-tier group responsible for each particular DNS request that the service machine receives for each particular domain name, and to forward the particular DNS request to the second-tier group that it identifies for the particular DNS request. The first-tier DNS service in some embodiments has only one group of service machines. Each first or second service machine group in some embodiments can have one or more service machines, and can be scaled up or down to add or remove service machines to the group (e.g., through an active/active layer 3 scaleout with BGP).

Abstract: An apparatus and method for manufacturing glass include a heat extractor configured to extract heat from molten glass. The heat extractor includes a first conduit and at least one second conduit which may include a plurality of second conduits circumferentially surrounding the first conduit. The first conduit and the at least one second conduit are configured to flow a fluid therethrough.

Abstract: The invention provides a composition and method for treating dyspepsia with asafoetida and milk thistle extract. A method of making the inventive composition is contemplated.

Abstract: An apparatus for activating a physical card in a virtual environment comprises a processor associated with a server. The processor is configured to receive a request to issue a physical card to a first user and to generate a first non-fungible token (NFT) for storage in the physical card, wherein the first NFT is then displayed as a digital card in a virtual environment. The processor is further configured to receive the digital card in an interaction and to generate a second NFT. The processor is further configured to combine the first NFT and the second NFT to generate an activation NFT that allows the physical card to access a profile corresponding to the first user during an interaction. The processor is further configured to transmit the activation NFT and an instruction to the first user device to store the activation NFT in the physical card.

Abstract: A method of forming a glass sheet comprises: (a) forming a ribbon of glass from molten glass with a pair of forming rollers; (b) reducing horizontal temperature variability of the ribbon of glass to be 10° C. or less across 80 percent of an entire width of the ribbon of glass before the ribbon of glass cools to a glass transition temperature; (c) controlling a cooling rate of the ribbon of glass while the ribbon of glass moves vertically downward within a setting zone such that the ribbon of glass has a first average cooling rate before the ribbon of glass cools to the glass transition temperature and a second average cooling rate after the ribbon of glass cools to the glass transition temperature, the first average cooling rate being less than the second average cooling rate; and (d) separating a glass sheet from the ribbon of glass.

Abstract: The invention relates to a plant-based glutamic acid rich protein composition and method of making the same. The composition provides a spectrum of amino acids, including an abundance of glutamic acid. The composition is free of the antibiotics and growth hormones associated with animal-sourced proteins and does not require amino acid supplementation to achieve high levels of glutamic acid. In some aspects, the composition is obtained from coffee beans, including defatted green coffee beans.

Abstract: The invention provides a composition comprising an extract of black pepper seeds having ?-caryophyllene as a bioactive ingredient. The invention also provides a method of providing pain relief, comprising administering to a subject in need thereof an effective amount of the inventive composition.

Abstract: The invention provides a composition comprising an extract of Artocarpus heterophyllus and methods using and manufacturing the composition in the treatment of lower urinary tract symptoms (LUTS). The extract can be derived from the leaves of Artocarpus heterophyllus and can be formulated with carriers, excipients, nutritional supplements, food supplements, and beverages. The extract finds use in the treatment of LUTS associated with prostate disorders, such as benign prostatic hyperplasia. The composition can similarly be administered in methods of promoting and maintaining the health of the urinary tract and prostate.

Abstract: The invention provides a composition comprising one or more hydroxytryptamides and method of its use in the treatment of neurodegenerative disorders. The invention includes embodiments wherein the composition comprises caffeine and chlorogenic acids. The composition finds use in the treatment of Alzheimer's disease and Parkinson's disease, including providing neuroprotection against the advancement of the symptoms of these disorders.