Abstract: Provided herein are expression cassettes for expressing a transgene in a liver cell, wherein the transgene encodes an ARSA polypeptide. Also provided are methods to treat metachromatic leukodystrophy (MLD). Further provided herein are vectors (e.g., rAAV vectors), viral particles, pharmaceutical compositions and kits for expressing an ARSA polypeptide in an individual in need thereof.

Abstract: The disclosure provides an approach for decentralizing control plane operations in a network environment that includes transport nodes configured to implement a logical overlay network. A method includes transmitting a global list of transport nodes to each of the plurality of transport nodes from a management plane, the global list including an ordered list of the plurality of transport nodes. The method also includes transmitting a neighbor index value to each of the plurality of transport nodes, where the transport nodes each compute a corresponding list of neighbor transport nodes based on the neighbor index value and the global list of transport nodes. The method also includes, based on determining an update to a state of the logical overlay network has occurred by a first transport node, transmitting an update message from the first transport node to each transport node in the first transport node's list of neighbor transport nodes.

Abstract: The disclosure provides an approach for decentralizing control plane operations in a network environment that includes transport nodes configured to implement a logical overlay network. A method includes transmitting a global list of transport nodes to each of the plurality of transport nodes from a management plane, the global list including an ordered list of the plurality of transport nodes. The method also includes transmitting a neighbor index value to each of the plurality of transport nodes, where the transport nodes each compute a corresponding list of neighbor transport nodes based on the neighbor index value and the global list of transport nodes. The method also includes, based on determining an update to a state of the logical overlay network has occurred by a first transport node, transmitting an update message from the first transport node to each transport node in the first transport node's list of neighbor transport nodes.

Abstract: The disclosure provides an approach for decentralizing control plane operations in a network environment that includes transport nodes configured to implement a logical overlay network. A method includes transmitting a global list of transport nodes to each of the plurality of transport nodes from a management plane, the global list including an ordered list of the plurality of transport nodes. The method also includes transmitting a neighbor index value to each of the plurality of transport nodes, where the transport nodes each compute a corresponding list of neighbor transport nodes based on the neighbor index value and the global list of transport nodes. The method also includes, based on determining an update to a state of the logical overlay network has occurred by a first transport node, transmitting an update message from the first transport node to each transport node in the first transport node's list of neighbor transport nodes.

Abstract: Systems and methods for self-characterization of a software-defined optical network are disclosed. A test transponder may generate and transmit test traffic using various combinations of transmission parameters to discern physical characteristic of a route between two network elements. The test transponder may compute optical characteristics of the route based on the physical characteristics and transmission parameters. An SDN controller may maintain a characterization database storing test results. The test results may be fed to a machine learning engine, which outputs predictions or recommendations regarding utilization of bandwidth and other resources. The optical network may be adapted to handle requested, observed, or predicted changes in on-demand traffic or traffic surges. The test results may be used to defragment the optical spectrum with minimal or no impact on existing traffic to make space in a flexible grid for newly launched channels or channels being moved to different spectrum locations.

Abstract: The disclosure provides an approach for decentralizing control plane operations in a network environment that includes transport nodes configured to implement a logical overlay network. A method includes transmitting a global list of transport nodes to each of the plurality of transport nodes from a management plane, the global list including an ordered list of the plurality of transport nodes. The method also includes transmitting a neighbor index value to each of the plurality of transport nodes, where the transport nodes each compute a corresponding list of neighbor transport nodes based on the neighbor index value and the global list of transport nodes. The method also includes, based on determining an update to a state of the logical overlay network has occurred by a first transport node, transmitting an update message from the first transport node to each transport node in the first transport node's list of neighbor transport nodes.

Abstract: The present invention relates to methods of reducing ?F508-CFTR ubiquitination or degradation, or increasing ?F508-CFTR processing or function in a CF cell comprising contacting the cell with a therapeutic agent that inhibits NEDD8, FBXO2, and/or SYVN1 expression in the cell.

Abstract: The present invention relates to therapeutic agents comprising miR-138, a miR-138 mimic, a SIN3A RNAi molecule, or a an anti-SIN3A RNAi molecule, and/or an anti-SIN3A antisense oligonucleotide (ASO) or other agent that suppresses SIN3A expression, a small molecule drug that interferes with SIN3A activity or whose actions mimic the biological effects of SIN3A suppression and methods of use of these therapeutic agents to treat cystic fibrosis.