Abstract: Systems and methods for detection of biological agents are generally described. Certain embodiments relate to circuits comprising a first semiconductor nanosensor and a second semiconductor nanosensor in electrical communication with the first semiconductor nanosensor. The circuit can be configured to output a differential electrical property between the first semiconductor nanosensor and the second semiconductor nanosensor when exposed to a sample comprising an analyte. In certain instances, the first semiconductor nanosensor is functionalized with a detector species, and the second semiconductor nanosensor is not functionalized with the detector species. In some cases, the first semiconductor nanosensor is functionalized with a detector species, and the second semiconductor nanosensor is associated with a gate.

Abstract: Aspects of the present disclosure provide measurement devices and methods for detecting electrical characteristics of devices under test (DUTs), such as semiconductor nanowires. Techniques described herein provide programmable measurement devices that may be implemented in a compact form factor while being able to perform reliable measurements. In some embodiments, measurement devices described herein may be programmed to modulate signals for transmitting to a DUT, and may demodulate signals from the DUTs adaptively using self-programming techniques described herein. Such self-programming may include applying a programmable phase delay to oscillator signals used during demodulation. In some embodiments, such measurement devices may be implemented on a single circuit board, in a single integrated circuit package, or even on a single solid-state semiconductor die. Techniques described herein may enable reliable, inexpensive, and small-scale fluid sample measurement devices.

Abstract: A nanoelectric field effect sensor uses the field created by the surface charge profile of biomolecular binding to modulate the current flowing between a source and a drain. We have shown that a patterned side or top gate can be used to calibrate the biomolecular field modulation. This approach provides an electrical sensitivity characterization of the sensor before exposing it to sample fluid. Furthermore, a side gate or a top gate voltage with the right sign can be used to control the binding event during functionalization or sensing. For instance, a negative gate voltage can prevent binding of negatively charged proteins on a sensor. This approach of electric-field control of binding can be used in a differential sensor configuration as well. For instance, in a two-sensor single-bridge technique, one of the sensors can be exposed to a local electric field to prevent binding events, which can then be used for background cancellation in a second sensor, not exposed to the electric field.

Abstract: This application describes a novel approach of wireless charging or powering of a sensor-based device used for in vivo diagnosis and monitoring. In addition to implantable or subcutaneous devices, this approach can also be used for wireless charging of wearable and handheld devices. Specifically, this application describes charging of diagnostic and monitoring devices used for disease detection and management. More specifically, this application describes a method to wirelessly power integrated devices designed to detect or monitor analytes (e.g. biological or chemical species) and release drugs into the body in response to a specific change in the body's vitals, detected by the device.

Abstract: A semiconductor sensor-based near-patient diagnostic system and related methods.

Abstract: Aspects of the present disclosure provide measurement devices and methods for detecting electrical characteristics of devices under test (DUTs), such as semiconductor nanowires. Techniques described herein provide programmable measurement devices that may be implemented in a compact form factor while being able to perform reliable measurements. In some embodiments, measurement devices described herein may be programmed to modulate signals for transmitting to a DUT, and may demodulate signals from the DUTs adaptively using self-programming techniques described herein. Such self-programming may include applying a programmable phase delay to oscillator signals used during demodulation. In some embodiments, such measurement devices may be implemented on a single circuit board, in a single integrated circuit package, or even on a single solid-state semiconductor die. Techniques described herein may enable reliable, inexpensive, and small-scale fluid sample measurement devices.

Abstract: A semiconductor sensor-based near-patient diagnostic system and related methods.

Abstract: A MEMS resonator is described.

Abstract: Systems and methods for detection of biological agents are generally described. Target biological agents may be detected by use of a sensor, which in some situations is a nanowire. An external electric field is applied in some embodiments to induce an electric dipole. The induced electric dipole is detected, allowing detection of the biological agent.

Abstract: The techniques relate to methods and apparatus for determining data indicative of a concentration of an analyte in a fluid. First data indicative of a first property measurement of a first sensor while in fluid communication with the fluid is accessed. Second data indicative of a second property measurement of a second sensor in fluid communication with the fluid is accessed. A set of one or more parameters related to the first sensor, the second sensor, or both are accessed. The data indicative of the concentration of the analyte in the fluid is determined based on the first property measurement, the second property measurement, and the set of one or more parameters.

Abstract: Systems and methods for detection of biological agents are generally described. Target biological agents may be detected by use of a sensor, which in some situations is a nanowire. An external electric field is applied in some embodiments to induce an electric dipole. The induced electric dipole is detected, allowing detection of the biological agent.

Abstract: The techniques relate to methods and apparatus for sealed fluid chambers. The device includes a plurality of sensor chips, each sensor chip comprising a set of sensor elements, wherein each sensor element of the set of sensor elements is configured to sense an analyte, at least one fluid chamber comprising an inner portion proximate to, and in fluid communication with, at least one of the plurality of sensor chips, and a sealing member between the at least one fluid chamber and the at least one of the plurality of sensor chips.

Abstract: The techniques relate to methods and apparatus for electroosmotic flow. A device includes a fluid chamber, at least one sensor element configured to sense an analyte, wherein the at least one sensor element is in fluid communication with the fluid chamber, and a set of electroosmotic electrodes disposed for creating an electroosmotic flow of a fluid in the fluid chamber over the at least one sensor element.

Abstract: Systems and methods for detecting a target species using a semiconductor nanosensor are generally described.

Abstract: Semiconductor-based sensor devices and methods for detection of biological agents are described herein.

Abstract: A semiconductor sensor-based near-patient diagnostic system and related methods.

Abstract: A semiconductor sensor-based near-patient diagnostic system and related

Abstract: A semiconductor sensor-based near-patient diagnostic system and related methods.

Abstract: The present invention generally relates to nanoantenna arrays and fabrication methods of said nanoantenna arrays. In particular, one aspect relates to nanoantenna arrays including nanostructures of predefined shapes in predefined patterns, which results in collective excitement of surface plasmons. The nanoantenna arrays can be used for spectroscopy and nanospectroscopy. Another aspects of the present invention relate to a method of high-throughput fabrication of nanoantenna arrays includes fabricating a reusable nanostencil for nanostensil lithography (NSL) which provides a mask to deposit materials onto virtually any support, such as flexible and thin-film stretchable supports. The nanostencil lithography methods enable high quality, high-throughput fabrication of nanostructures on conducting, non-conducting and magnetic supports. The nanostencil can be prepared by etching nanoapertures of predefined patterns into a waffer or ceramic membrane.

Abstract: Systems and methods for detecting a target species using a semiconductor nanosensor are generally described.