Abstract: Provided are methods and compositions for promoting tissue (e.g., muscle) regeneration using one or more activators of fatty acid oxidation, such as one or more PPAR? activators. The methods and compositions described herein are also useful for promoting tissue growth, inducing proliferation of stem cells, inducing differentiation of tissuegenic cells (e.g., myogenic cells), and treating a disease or condition associated with a tissue (e.g., muscle), such as tissue injury, degeneration or aging, in an individual.

Abstract: A composition used for combating metabolic diseases and uses of (or a method for) the composition. The pharmaceutical composition comprises therapeutic agent A or a pharmaceutically acceptable salt thereof; therapeutic agent B or a pharmaceutically acceptable salt thereof; and at least one pharmaceutically acceptable excipient, where therapeutic agent A is a non-steroidal anti-inflammatory medicament, and therapeutic agent B is a fatty acid oxidation inhibitor. The pharmaceutical composition effectively treats or prevents obesity, non-alcoholic fatty liver, polycystic ovary syndrome, type 2 diabetes, and metabolic syndrome diseases caused by insulin resistance.

Abstract: Provided are compositions and methods of using engineered myogenic cells for delivery of an agent to an individual. Also provided are methods of producing reprogrammed myogenic cells from adult myogenic cells, and use of the reprogrammed myogenic cells for therapy and agent delivery.

Abstract: The present disclosure describes compositions for preparing a myofiber or myotube from a skeletal muscle stem cell or progenitor cell comprising a carnitine and/or a derivative thereof, a fatty acid a steroid and combinations thereof. Preferred embodiment comprises of 0.1 mM L-carnitine, 0.2 mM 9-cis-linoleic acid and 10 mM dihydrotestosterone. Also disclosed is a composition for inducing expansion of skeletal muscle stem cells or progenitor cells comprising a fibroblast growth factor agonist, a Notch signalling agonist, a nucleic acid, and combinations thereof. Preferred embodiment comprises 20 ng/ml basic fibroblast growth factor (bFGF), 50 ?g/ml Delta-like ligand 1 (DLL1), 10 mM hypoxanthine and 1.6 mM thymidine.