Patents by Inventor Shyh-Dar Li
Shyh-Dar Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240010679Abstract: The present invention relates to anti-nociceptive compounds and uses thereof. In some embodiments, the present invention provides LEU-ENK analogues for treating pain, anxiety, mood disorders or depression.Type: ApplicationFiled: November 18, 2021Publication date: January 11, 2024Inventors: Shyh-Dar LI, KK Durgra Rao VISWANADHAM, Roland BOETTGER
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Publication number: 20210379214Abstract: Provided herein are phospholipid-free small unilamellar vesicle (PFSUV) compositions, including a steroid and a non-ionic surfactant wherein the molar ratio of steroid:nonionic surfactant is between 3:1 to 5:1. Furthermore, the compositions described herein were found to useful for drug loading, drug delivery where preferential targeting of drugs to the liver is of interest.Type: ApplicationFiled: October 31, 2019Publication date: December 9, 2021Inventors: Shyh-Dar Li, Wunan Zhang, Po-Han Chao, Roland Boettger
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Publication number: 20140079644Abstract: In one aspect, there is provided a compound comprising an acetylated carboxymethylcellulose (CMC-Ac) covalently linked to: at least one poly(ethylene glycol) (PEG), and at least one hydrophobic drug. In another aspect, a self-assembling nanoparticle composition comprising such compounds is provided.Type: ApplicationFiled: November 19, 2013Publication date: March 20, 2014Applicant: ONTARIO INSTITUTE FOR CANCER RESEARCHInventors: Shyh-Dar Li, Mark John Ernsting, Wei-Lun Tang
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Patent number: 8673863Abstract: A delivery system is provided. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid derivative, a polyethylene glycol (PEG) or a polyethylene glycol derivative bonded thereto, and a glutathione (GSH) or a glutathione derivative bonded to the polyethylene glycol or the polyethylene glycol derivative.Type: GrantFiled: November 2, 2011Date of Patent: March 18, 2014Assignee: Industrial Technology Research InstituteInventors: Ae-June Wang, Chi-Heng Jian, Shyh-Dar Li, Yi-Fong Lin, Shin-Jr Liu
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Patent number: 8591877Abstract: In one aspect, there is provided a compound comprising an acetylated carboxymethylcellulose (CMC-Ac) covalently linked to: at least one poly(ethylene glycol) (PEG), and at least one hydrophobic drug. In another aspect, a self-assembling nanoparticle composition comprising such compounds is provided.Type: GrantFiled: February 1, 2012Date of Patent: November 26, 2013Assignee: Ontario Institute for Cancer ResearchInventors: Shyh-Dar Li, Mark John Ernsting, Wei-Lun Tang
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Patent number: 8569239Abstract: A delivery system. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid derivative, a polyethylene glycol (PEG) or a polyethylene glycol derivative bonded thereto, and a glutathione (GSH) or a glutathione derivative bonded to the polyethylene glycol or the polyethylene glycol derivative.Type: GrantFiled: March 11, 2010Date of Patent: October 29, 2013Assignee: Industrial Technology Research InstituteInventors: Ae-June Wang, Chi-Heng Jian, Shyh-Dar Li, Yi-Fong Lin, Shih-Jr Liu
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Patent number: 8389768Abstract: Provided herein are novel cationic lipids, compositions comprising the cationic lipids, and methods of using the cationic lipids. In some claims, the cationic lipids have cytotoxic activity and can be used alone or in combination with a cytotoxic bioactive compound to kill a cell. In some of these claims, the cationic lipid enhances the cytotoxic activity of the cytotoxic bioactive compound. Methods for treating a subject afflicted with a disease or unwanted condition are provided, wherein the method comprises administering a delivery system comprising a novel cationic lipid to the subject. The invention further provides methods for making delivery systems comprising the novel cationic lipids of the invention.Type: GrantFiled: May 1, 2009Date of Patent: March 5, 2013Assignee: The University of North Carolina at Chapel HillInventors: Leaf Huang, Yunching Chen, Joyeeta Sen, Surendar Reddy Bathula, Sumio Chono, Shyh-Dar Li, Michael Hackett
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Publication number: 20120219508Abstract: In one aspect, there is provided a compound comprising an acetylated carboxymethylcellulose (CMC-Ac) covalently linked to: at least one poly(ethylene glycol) (PEG), and at least one hydrophobic drug. In another aspect, a self-assembling nanoparticle composition comprising such compounds is provided.Type: ApplicationFiled: February 1, 2012Publication date: August 30, 2012Inventors: SHYH-DAR LI, Mark John Ernsting, Wei-Lun Tang
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Patent number: 8128945Abstract: A vector for targeted delivery of drugs into estrogen receptors over-expressed cells is disclosed. The vector of the present invention is mainly about an active targeting delivery carrier which consists of a plurality of nanoparticles including: (i) a plurality of targeted moiety conjugated to the outer surface of the nanoparticles, the moiety being capable of binding with the estrogen receptor of a target cell, and (ii) bioactive agents encapsulated in the nanoparticles or forming complex with the nanoparticles. The targeted moiety of the present invention can also be conjugated to parent drugs for prodrug design.Type: GrantFiled: September 20, 2010Date of Patent: March 6, 2012Assignee: Industrial Technology Research InstituteInventors: Shyh-Dar Li, Ae-June Wang, Chung-Kung Lai
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Patent number: 8067380Abstract: A delivery system is provided. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid derivative, a polyethylene glycol (PEG) or a polyethylene glycol derivative bonded thereto, and a glutathione (GSH) or a glutathione derivative bonded to the polyethylene glycol or the polyethylene glycol derivative.Type: GrantFiled: October 2, 2008Date of Patent: November 29, 2011Assignee: Industrial Technology Research InstituteInventors: Ae-June Wang, Chi-Heng Jian, Shyh-Dar Li, Yi-Fong Lin, Shin-Jr Liu
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Publication number: 20110117026Abstract: The present invention provides compositions comprising delivery systems comprising a lipid vehicle, a bioactive compound, and a polyanionic carrier macromolecule that is not a carrier polynucleotide, wherein the lipid vehicle encapsulates the polynucleotide of interest and the polyanionic carrier macromolecule, and wherein the delivery system is essentially free of carrier polynucleotides. Compositions also include delivery systems comprising a lipid vehicle and a bioactive agent, wherein the lipid vehicle encapsulates the bioactive agent, and wherein the lipid vehicle comprises a covalent bilayer or a core supported bilayer comprising polycationic lipids. Other compositions provided herein comprise a delivery system comprising a polypeptide of interest and a means for delivering the polypeptide into a cell.Type: ApplicationFiled: May 1, 2009Publication date: May 19, 2011Inventors: Yu-Chen Tseng, Sang Kyoon Kim, Michael Hackett, Sumio Chono, Leaf Huang, Shyh-dar Li
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Publication number: 20110117141Abstract: Provided herein are novel cationic lipids, compositions comprising the cationic lipids, and methods of using the cationic lipids. In some claims, the cationic lipids have cytotoxic activity and can be used alone or in combination with a cytotoxic bioactive compound to kill a cell. In some of these claims, the cationic lipid enhances the cytotoxic activity of the cytotoxic bioactive compound. Methods for treating a subject afflicted with a disease or unwanted condition are provided, wherein the method comprises administering a delivery system comprising a novel cationic lipid to the subject. The invention further provides methods for making delivery systems comprising the novel cationic lipids of the invention.Type: ApplicationFiled: May 1, 2009Publication date: May 19, 2011Inventors: Leaf Huang, Yunching Chen, Joyeeta Sen, Surendar Reddy Bathula, Sumio Chono, Shyh-Dar Li, Michael Hackett
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Publication number: 20110008262Abstract: A vector for targeted delivery of drugs into estrogen receptors over-expressed cells is disclosed. The vector of the present invention is mainly about an active targeting delivery carrier which consists of a plurality of nanoparticles including: (i) a plurality of targeted moiety conjugated to the outer surface of the nanoparticles, the moiety being capable of binding with the estrogen receptor of a target cell, and (ii) bioactive agents encapsulated in the nanoparticles or forming complex with the nanoparticles. The targeted moiety of the present invention can also be conjugated to parent drugs for prodrug design.Type: ApplicationFiled: September 20, 2010Publication date: January 13, 2011Inventors: Shyh-Dar LI, Ae-June Wang, Chung-Kung Lai
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Patent number: 7820204Abstract: A vector for targeted delivery of drugs into estrogen receptors over-expressed cells is disclosed. The vector of the present invention is mainly about an active targeting delivery carrier which consists of a plurality of nanoparticles including: (i) a plurality of targeted moiety conjugated to the outer surface of the nanoparticles, the moiety being capable of binding with the estrogen receptor of a target cell, and (ii) bioactive agents encapsulated in the nanoparticles or forming complex with the nanoparticles. The targeted moiety of the present invention can also be conjugated to parent drugs for prodrug design.Type: GrantFiled: December 30, 2003Date of Patent: October 26, 2010Assignee: Industrial Technology Research InstituteInventors: Shyh-Dar Li, Ae-June Wang, Chung-Kung Lai
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Patent number: 7803398Abstract: A targeting delivery system. The targeted delivery system includes a carrier for a drug and a targeted ligand modifying the carrier to target the encapsulated drug to a sigma receptor over-expressed cell.Type: GrantFiled: December 23, 2004Date of Patent: September 28, 2010Assignee: Industrial Technology Research InstituteInventors: Shyh-Dar Li, Ae-June Wang, Leaf Huang
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Publication number: 20100166849Abstract: A delivery system. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid derivative, a polyethylene glycol (PEG) or a polyethylene glycol derivative bonded thereto, and a glutathione (GSH) or a glutathione derivative bonded to the polyethylene glycol or the polyethylene glycol derivative.Type: ApplicationFiled: March 11, 2010Publication date: July 1, 2010Inventors: Ae-June WANG, Chi-Heng Jian, Shyh-Dar Li, Yi-Fong Lin, Shih-Jr Liu
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Patent number: 7700564Abstract: A delivery system. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid derivative, a polyethylene glycol (PEG) or a polyethylene glycol derivative bonded thereto, and a glutathione (GSH) or a glutathione derivative bonded to the polyethylene glycol or the polyethylene glycol derivative.Type: GrantFiled: November 3, 2008Date of Patent: April 20, 2010Assignee: Industrial Technology Research InstituteInventors: Ae-June Wang, Chi-Heng Jian, Shyh-Dar Li, Yi-Fong Lin, Shih-Jr Liu
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Publication number: 20090123531Abstract: A delivery system is provided. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid derivative, a polyethylene glycol (PEG) or a polyethylene glycol derivative bonded thereto, and a glutathione (GSH) or a glutathione derivative bonded to the polyethylene glycol or the polyethylene glycol derivative.Type: ApplicationFiled: October 2, 2008Publication date: May 14, 2009Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Ae-June WANG, Chi-Heng JIAN, Shyh-Dar LI, Yi-Fong LIN, Shin-Jr LIU
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Publication number: 20090060991Abstract: A delivery system. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid derivative, a polyethylene glycol (PEG) or a polyethylene glycol derivative bonded thereto, and a glutathione (GSH) or a glutathione derivative bonded to the polyethylene glycol or the polyethylene glycol derivative.Type: ApplicationFiled: November 3, 2008Publication date: March 5, 2009Inventors: Ae-June WANG, Chi-Heng JIAN, Shyh-Dar LI, Yi-Fong LIN, Shih-Jr LIU
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Patent number: 7446096Abstract: A delivery system. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid derivative, a polyethylene glycol (PEG) or a polyethylene glycol derivative bonded thereto, and a glutathione (GSH) or a glutathione derivative bonded to the polyethylene glycol or the polyethylene glycol derivative.Type: GrantFiled: December 19, 2005Date of Patent: November 4, 2008Assignee: Industrial Technology Research InstituteInventors: Ae-June Wang, Chi-Heng Jian, Shyh-Dar Li, Yi-Fong Lin, Shih-Jr Liu