Patents by Inventor Shyni Varghese

Shyni Varghese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220249533
    Abstract: The present disclosure relates to polymer-based biomaterials for the systemic or localized delivery of osteoanabolic molecules, and their use in methods for treating and/or preventing bone degeneration and for promoting bone regeneration. In one aspect, the present invention provides a biomaterial comprising a polymer and a bioactive molecule binding moiety. In certain embodiments of the first aspect of the invention, the bioactive molecule binding moiety is an osteoanabolic molecule binding moiety.
    Type: Application
    Filed: June 3, 2020
    Publication date: August 11, 2022
    Applicant: DUKE UNIVERSITY
    Inventors: Shyni Varghese, Yu Ru Shih, Jiaul Hoque
  • Patent number: 10850274
    Abstract: The disclosure provides for microfluidic devices comprising patterned hydrogels with embedded cells or microtissues.
    Type: Grant
    Filed: April 9, 2016
    Date of Patent: December 1, 2020
    Assignee: The Regents of the University of California
    Inventors: Shyni Varghese, Aereas Aung, Han Liang Lim
  • Publication number: 20180085750
    Abstract: The disclosure provides for microfluidic devices comprising patterned hydrogels with embedded cells or microtissues.
    Type: Application
    Filed: April 9, 2016
    Publication date: March 29, 2018
    Inventors: Shyni Varghese, Aereas Aung, Han Liang Lim
  • Publication number: 20140243428
    Abstract: The disclosure provides for self-healing hydrogels, complex structures made therefrom, and use thereof, including use of the hydrogels as self-healing coatings, self-healing sealants, tissue adhesives, and drug carriers.
    Type: Application
    Filed: February 21, 2014
    Publication date: August 28, 2014
    Inventors: Shyni Varghese, Ameya Phadke
  • Publication number: 20140212968
    Abstract: Provided herein is a synthetic polymer-based hydrogel for the self-renewal and expansion of human stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Also provided are methods of making and using the same.
    Type: Application
    Filed: April 18, 2014
    Publication date: July 31, 2014
    Inventors: Shyni VARGHESE, Chien-Wen CHANG, Yongsung HWANG
  • Patent number: 8709452
    Abstract: The disclosure provides bone-mimetic mineral/polymer composite materials useful for formation of artificial bone grafts and for bone tissue engineering. The disclosure provides a hydrogels, cryogels and macroporous compositions modified with varying lengths of anionic pendant side chains (CH2?CHCONH(CH2)nCOOH, where n=1 to 12).
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: April 29, 2014
    Assignee: The Regents of the University of California
    Inventors: Shyni Varghese, Ameya Phadke
  • Publication number: 20130177980
    Abstract: Provided herein is a synthetic polymer-based hydrogel for the self-renewal and expansion of human stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Also provided are methods of making and using the same.
    Type: Application
    Filed: December 6, 2012
    Publication date: July 11, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Shyni Varghese, Chien-Wen Chang, Yongsung Hwang
  • Publication number: 20130017232
    Abstract: The disclosure provides Bone-mimetic mineral/polymer composite materials useful for formation of artificial bone grafts and for bone tissue engineering. The disclosure provides a hydrogels, cryogels and macroporous compositions modified with varying lengths of anionic pendant side chains (CH2?CHCONH(CH2)nCOOH, where n=1 to 12).
    Type: Application
    Filed: July 13, 2012
    Publication date: January 17, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Shyni Varghese, Ameya Phadke
  • Publication number: 20100227836
    Abstract: Materials and methods for local delivery of a glucosamine are provided to facilitate bone and cartilage growth.
    Type: Application
    Filed: September 30, 2009
    Publication date: September 9, 2010
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: JENNIFER H. ELISSEEFF, SHYNI VARGHESE, JEANNINE COBURN, MATTHEW GIBSON, ZAYNA NAHAS, ZHAOYANG YE
  • Patent number: 6794467
    Abstract: The invention discloses a process for the preparation of polymeric absorbents useful for gelling organic liquids. The process comprises mixing one or more monomers with a cross-linking agent, a free radical initiator, an optional solvent, optionally in the presence of a transition metal source and subjecting the mixture so obtained to a conventional polymerisation method. The polymer is removed, crushed to obtain polymer powder, washed with solvent and dried by conventional methods to remove unreacted monomers, followed by swelling in alcohols to obtain the desired product.
    Type: Grant
    Filed: March 27, 2000
    Date of Patent: September 21, 2004
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ashish Kishor Lele, Shyni Varghese, Manohar Virupax Badiger, Raghunath Anant Mashelkar
  • Publication number: 20030187172
    Abstract: The invention discloses a process for the preparation of polymeric absorbents useful for gelling organic liquids. The process comprises mixing one or more monomers with a cross-linking agent, a free radical initiator, an optional solvent, optionally in the presence of a transition metal source and subjecting the mixture so obtained to a conventional polymerisation method. The polymer is removed, crushed to obtain polymer powder, washed with solvent and dried by conventional methods to remove unreacted monomers, followed by swelling in alcohols to obtain the desired product.
    Type: Application
    Filed: March 27, 2000
    Publication date: October 2, 2003
    Inventors: Ashish Kishor Lele, Shyni Varghese, Manohar Virupax Badiger, Raghunath Anant Mashelkar