Patents by Inventor Si-Han Wu

Si-Han Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Magnetoresistive random access memory
    Patent number: 12232425
    Abstract: A magnetoresistive random access memory (MRAM) device includes a first array region and a second array region on a substrate, a first magnetic tunneling junction (MTJ) on the first array region, a first top electrode on the first MTJ, a second MTJ on the second array region, and a second top electrode on the second MTJ. Preferably, the first top electrode and the second top electrode include different nitrogen to titanium (N/Ti) ratios.
    Type: Grant
    Filed: November 21, 2023
    Date of Patent: February 18, 2025
    Assignee: UNITED MICROELECTRONICS CORP.
    Inventors: Hui-Lin Wang, Si-Han Tsai, Dong-Ming Wu, Chen-Yi Weng, Ching-Hua Hsu, Ju-Chun Fan, Yi-Yu Lin, Che-Wei Chang, Po-Kai Hsu, Jing-Yin Jhang
  • Method for delivering an agent to posterior segment of an eye and uses thereof
    Patent number: 12016958
    Abstract: The disclosure provides a method for delivering an agent to posterior segment of an eye comprising administrating a pharmaceutical composition comprising the agent and mesoporous silica nanoparticles to the eye. An eye drop and a method for treating an ocular disease in a subject in need of such treatment are also provided.
    Type: Grant
    Filed: February 25, 2022
    Date of Patent: June 25, 2024
    Assignee: NANO TARGETING & THERAPY BIOPHARMA INC.
    Inventors: Cheng-Hsun Wu, Si-Han Wu, Yi-Ping Chen, Rong-Lin Zhang, Tien-Chun Yang, Chung-Yuan Mou, Hardy Wai Hong Chan
  • METHOD FOR TREATING A CANCER AND/OR CANCER METASTASIS
    Publication number: 20240139337
    Abstract: The present disclosure relates to a method for treating a cancer and/or cancer metastasis in a subject comprising administering to the subject irinotecan loaded in a mesoporous silica nanoparticle. The present disclosure also provides a conjugate comprising an agent loaded in a mesoporous silica nanoparticle (MSN) defining at least one pore and having at least one functional group on a sidewall of the at least one pore.
    Type: Application
    Filed: November 2, 2022
    Publication date: May 2, 2024
    Inventors: Cheng-Hsun WU, SI-HAN WU, YI-PING CHEN, RONG-LIN ZHANG, CHUNG-YUAN MOU, Yu-Tse LEE
  • DRUG-LOADED MESOPOROUS SILICA NANOPARTICLE FOR PREVENTION AND TREATMENT OF BRAIN CANCERS OR BRAIN METASTASES
    Publication number: 20230255926
    Abstract: The present disclosure relates to a method of preventing or treating brain cancers or brain metastases with mesoporous silica nanoparticles (MSNs) loaded with taxane-based chemotherapeutic drugs, in particular paclitaxel (PTX), cabazitaxel (CTX) or docetaxel (DTX), and the MSNs loaded with PTX, CTX or DTX.
    Type: Application
    Filed: October 13, 2022
    Publication date: August 17, 2023
    Inventors: Cheng-Hsun WU, Si-Han WU, Rong-Lin ZHANG, Chung-Yuan MOU, Hardy Wai Hong CHAN
  • Silica-based biomolecule carrier, pharmaceutical composition comprising the same, preparation method and use thereof
    Patent number: 11666662
    Abstract: Silica-based biomolecule carriers, compositions comprising the same and preparation methods and uses thereof for delivering biomolecules into a cell are provided. The silica-based biomolecule carrier comprises a porous core; a first bioactive moiety; a second bioactive moiety functionally associated with the first bioactive moiety; and linkers for respectively conjugating the first bioactive moiety and the second bioactive moiety to the porous core.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: June 6, 2023
    Assignee: NATIONAL TAIWAN UNIVERSITY
    Inventors: Chung-Yuan Mou, Yi-Ping Chen, Si-Han Wu
  • METHOD FOR DELIVERING AN AGENT TO POSTERIOR SEGMENT OF AN EYE AND USES THEREOF
    Publication number: 20220273583
    Abstract: The disclosure provides a method for delivering an agent to posterior segment of an eye comprising administrating a pharmaceutical composition comprising the agent and mesoporous silica nanoparticles to the eye. An eye drop and a method for treating an ocular disease in a subject in need of such treatment are also provided.
    Type: Application
    Filed: February 25, 2022
    Publication date: September 1, 2022
    Inventors: CHENG-HSUN WU, SI-HAN WU, YI-PING CHEN, RONG-LIN ZHANG, TIEN-CHUN YANG, CHUNG-YUAN MOU, HARDY WAI HONG CHAN
  • Surface-modified mesoporous silica nanoparticle for blood-brain barrier penetration,tumor targeting and cancer metastasis treatment, methods of production and uses thereof
    Patent number: 11419826
    Abstract: The present disclosure relates to mesoporous silica nanoparticles (MSNs) with specific modifications as drug delivery systems containing both tumor targeting and blood-brain barrier (BBB) penetration properties suitable for cancer treatment and/or CNS disease treatment. The present disclosure also relates to method of preparing MSNs and the MSNs prepared by the method as described herein.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: August 23, 2022
    Assignee: NANO TARGETING & THERAPY BIOPHARMA INC.
    Inventors: Cheng-Hsun Wu, Yi-Ping Chen, Si-Han Wu, Chung-Yuan Mou
  • HIGH-DENSITY AND SHORT-CHAIN PEG MODIFIED NANO-SIZED CARRIERS AND THEIR USES
    Publication number: 20220202954
    Abstract: The present disclosure relates to PEGylated surface, in particular nano-sized carriers with such surface, in medical applications, such as a drug delivery system. Particularly, the PEGylated nano-sized carriers may solve the immunological issues caused by or related to polyethylene glycol-containing substances.
    Type: Application
    Filed: December 30, 2021
    Publication date: June 30, 2022
    Inventors: Si-Han WU, Kuo-Hsiang CHUANG, Yi-Ping CHEN
  • SILICA NANOSPHERE FOR IMMUNOTHERAPY
    Publication number: 20210015943
    Abstract: The present disclosure relates to a field of hollow silica nanospheres. Particularly, the present disclosure relates to silica nanoparticles as adjuvant to induce or enhance immune response or as carrier to deliver antigen to a body.
    Type: Application
    Filed: July 17, 2020
    Publication date: January 21, 2021
    Inventors: Chung-Yuan MOU, Cheng-Hsun WU, Si-Han WU, Yi-Ping CHEN
  • DRUG DELIVERY BY PORE-MODIFIED MESOPOROUS SILICA NANOPARTICLES
    Publication number: 20210015757
    Abstract: The present disclosure relates to mesoporous silica nanoparticles having modifications on the surface of the (extended) mesopores, which can be further loaded with one or more types of bioactive ingredients within the (extended) mesopores mesopores, processes of preparing the same and applications of the same.
    Type: Application
    Filed: July 17, 2020
    Publication date: January 21, 2021
    Inventors: Hardy Wai Hong CHAN, Chung-Yuan MOU, Cheng-Hsun WU, Si-Han WU, Yi-Ping CHEN, Rong-Lin ZHANG
  • SURFACE-MODIFIED MESOPOROUS SILICA NANOPARTICLE FOR BLOOD-BRAIN BARRIER PENETRATION,TUMOR TARGETING AND CANCER METASTASIS TREATMENT, METHODS OF PRODUCTION AND USES THEREOF
    Publication number: 20200345649
    Abstract: The present disclosure relates to mesoporous silica nanoparticles (MSNs) with specific modifications as drug delivery systems containing both tumor targeting and blood-brain barrier (BBB) penetration properties suitable for cancer treatment and/or CNS disease treatment. The present disclosure also relates to method of preparing MSNs and the MSNs prepared by the method as described herein.
    Type: Application
    Filed: April 30, 2020
    Publication date: November 5, 2020
    Inventors: Cheng-Hsun WU, Yi-Ping CHEN, Si-Han WU, Chung-Yuan MOU
  • Hollow silica nanoparticles with encapsulated bioactive ingredients, preparation process and applications thereof
    Patent number: 10729783
    Abstract: The present invention relates to hollow silica nanoparticles as a drug delivery system loading bioactive ingredients. Particularly, the present invention relates to silica nanoparticles comprising multi-layered silica shells with one or more bioactive ingredients encapsulated within and their applications in drug delivery; and processes of preparing the same.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: August 4, 2020
    Assignee: NATIONAL TAIWAN UNIVERSITY
    Inventors: Chung-Yuan Mou, Nai-Yuan Kou, Si-Han Wu, Yi-Ping Chen
  • SILICA-BASED BIOMOLECULE CARRIER, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, PREPARATION METHOD AND USE THEREOF
    Publication number: 20180228918
    Abstract: Silica-based biomolecule carriers, compositions comprising the same and preparation methods and uses thereof for delivering biomolecules into a cell are provided. The silica-based biomolecule carrier comprises a porous core; a first bioactive moiety; a second bioactive moiety functionally associated with the first bioactive moiety; and linkers for respectively conjugating the first bioactive moiety and the second bioactive moiety to the porous core.
    Type: Application
    Filed: January 20, 2016
    Publication date: August 16, 2018
    Inventors: Chung-Yuan MOU, Yi-Ping CHEN, Si-Han WU
  • HOLLOW SILICA NANOPARTICLES WITH ENCAPSULATED BIOACTIVE INGREDIENTS, PREPARATION PROCESS AND APPLICATIONS THEREOF
    Publication number: 20180050115
    Abstract: The present invention relates to hollow silica nanoparticles as a drug delivery system loading bioactive ingredients. Particularly, the present invention relates to silica nanoparticles comprising multi-layered silica shells with one or more bioactive ingredients encapsulated within and their applications in drug delivery; and processes of preparing the same.
    Type: Application
    Filed: August 18, 2017
    Publication date: February 22, 2018
    Inventors: Chung-Yuan MOU, Nai-Yuan KOU, Si-Han WU, Yi-Ping CHEN
  • SILICA-BASED MESOPOROUS CARRIER AND DELIVERY METHOD OF USING THE SAME
    Publication number: 20160038608
    Abstract: Mesoporous carriers for delivering targets into a cell are provided. The mesoporous carriers comprise hollow silica nanospheres (HSN) or mesoporous silica nanoparticles (MSN) and the targets bound to or encapsulated by the hollow silica nanospheres or the mesoporous silica nanoparticles. The targets includes at least two different targets, and the targets may include peptides, proteins, enzymes and/or enzymatic mimetics.
    Type: Application
    Filed: August 6, 2015
    Publication date: February 11, 2016
    Inventors: Chung-Yuan Mou, Yi-Ping Chen, Si-Han Wu