Patents by Inventor Si-Yeong CHOI

Si-Yeong CHOI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220409698
    Abstract: The present invention relates to a composition which is for preventing or treating bone diseases and includes CCR2 as an active ingredient. It was confirmed that a C—C chemokine receptor type 2 (CCR2) protein, a polynucleotide encoding the CCR2 protein, or a mesenchymal stem cell transduced with the CCR2 according to the present invention neutralize bone disease factor MCP-1, thereby reducing the collagen epitope (CTX-II) and collagen metabolism factors (MMP1 and MMP3) relating to collagen absorption in the body. In addition, it was confirmed that the expression of the SOX9 gene and anti-inflammatory cytokines (TGF-? and IL-10) related to cartilage differentiation was significantly increased. Thus, the present invention has excellent regenerative ability against osteoarthritis and excellent pain suppression and alleviation effects, and thus can be effectively used for preventing or treating bone diseases such as osteoarthritis.
    Type: Application
    Filed: November 15, 2019
    Publication date: December 29, 2022
    Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Seok-Jung KIM, Mi-La CHO, Hyun-Sik NA, Seon-Yeong LEE, Si-Yeong CHOI, Ji-Ye KWUAN, Keun-Hyung CHO, Goo-Young KIM, Seon-Ae KIM, Eeu-Jeong GO, Jeong-Won CHOI, Jin-Ah BAEK
  • Publication number: 20220251155
    Abstract: The present invention relates to: a recombinant peptide in which a Mitochondria Localization Sequence (MLS) peptide and the Signal Transducer and Activator of Transcription 3 (STAT3) are fused to each other; a recombinant vector carrying a polynucleotide coding for the recombinant peptide; and a composition comprising the recombinant peptide or the recombinant vector as an active ingredient for prevention or treatment of autoimmune disease or inflammatory disease, wherein the recombinant peptide or the recombinant vector allows STAT3 to be overexpressed in the mitochondria to enhance the mitochondrial function, resulting in inhibiting the expression of inflammatory cytokines including IL-17, whereby the composition may be advantageously used for preventing or treating autoimmune disease or inflammatory diseases.
    Type: Application
    Filed: January 28, 2020
    Publication date: August 11, 2022
    Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Mi-La CHO, Sung-Hwan PARK, Seon-Yeong LEE, Su-Jin MOON, Eun-kyung KIM, Jun-Geol RYU, Si-Yeong CHOI, Jeong-Won CHOI, Kyung-Ah JUNG, A-Ram LEE, Chul-Woo YANG, Jeong-Hyeon MOON