Patents by Inventor Siah Chong Cheong
Siah Chong Cheong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10792661Abstract: A device includes a first structure with a sheet layer with a plurality of discrete through-holes and a second structure coupled to the first structure. At least a portion of a first surface of the sheet layer of the first structure is exposed from the second structure. A top portion of the sheet layer, including the exposed portion of the first surface of the sheet layer, includes fluorocarbon. The second structure includes a material of a higher surface tension than the top of the sheet layer. A second surface of the sheet layer, opposite to the first surface of the sheet layer, is embedded in the second structure. The second structure extends at least partially into the plurality of discrete through-holes of the first structure.Type: GrantFiled: April 11, 2018Date of Patent: October 6, 2020Assignee: CURIOX BIOSYSTEMS PTE LTD.Inventors: Eng Seng Lim, Siah Chong Cheong, Namyong Kim
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Patent number: 10725020Abstract: The present invention provides an apparatus for conducting biological assays which employs “virtual wells” in lieu of the physical wells of conventional array plates. Also provided are methods of processing a sample and/or culturing cells using the apparatus and systems described herein. In some embodiments, the apparatus includes a first structure having a sheet layer with a plurality of discrete through holes; and a second structure coupled to the first structure, the second structure including a base layer. At least a portion of a first surface of the sheet layer of the first structure is exposed from the second structure, and a second surface of the sheet layer, opposite to the first surface of the sheet layer, is embedded in the base layer of the second structure adjacent the first surface of the base layer.Type: GrantFiled: October 9, 2013Date of Patent: July 28, 2020Assignee: Curiox Biosystems Pte Ltd.Inventors: Kong Leong Cheng, Siah Chong Cheong, Namyong Kim, Eng Seng Lim, Hanwen Melvin Lye, Zhong Wang, Wan Yee Leong, Mark S. Phong
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Patent number: 10632468Abstract: An apparatus configured for improving retention of non-adherent cells is disclosed. The apparatus includes a plate that includes a number of elements having a first surface energy arranged in an array with an overlay, on the plate, having a second surface energy. The first surface energy results in a hydrophilic surface and the second surface energy results in a hydrophobic surface. A diameter of the elements is at least 1 mm. A height of the overlay having the second surface energy, which results in a hydrophobic surface, is between 5% and 100% of the diameter of the elements. The apparatus also includes a wall circumferential to the plate. A method for performing multiple reactions with the apparatus is also disclosed.Type: GrantFiled: January 30, 2018Date of Patent: April 28, 2020Assignee: Curiox Biosystems Pte Ltd.Inventors: Namyong Kim, Siah Chong Cheong, Hanwen Melvin Lye, Mark Siew Peng Phong, Li Li, Teow Soon Seah
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Publication number: 20190280856Abstract: Described herein is a blockchain method and system for applied cryptographic IP management. This method and system for may include generating an IP datablock from an IP file. The IP datablock is preferably for use in updating an IP blockchain to thereby register the IP file and to enable verification of IP thereagainst.Type: ApplicationFiled: May 19, 2016Publication date: September 12, 2019Inventors: Siah Chong CHEONG, Sain Keat CHUANG, Tralvex @ Rex Yeap YEAP, Kai Tien LING
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Publication number: 20180229233Abstract: A device includes a first structure with a sheet layer with a plurality of discrete through-holes and a second structure coupled to the first structure. At least a portion of a first surface of the sheet layer of the first structure is exposed from the second structure. A top portion of the sheet layer, including the exposed portion of the first surface of the sheet layer, includes fluorocarbon. The second structure includes a material of a higher surface tension than the top of the sheet layer. A second surface of the sheet layer, opposite to the first surface of the sheet layer, is embedded in the second structure. The second structure extends at least partially into the plurality of discrete through-holes of the first structure.Type: ApplicationFiled: April 11, 2018Publication date: August 16, 2018Inventors: Eng Seng Lim, Siah Chong Cheong, Namyong Kim
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Publication number: 20180221868Abstract: An apparatus configured for improving retention of non-adherent cells is disclosed. The apparatus includes a plate that includes a number of elements having a first surface energy arranged in an array with an overlay, on the plate, having a second surface energy. The first surface energy results in a hydrophilic surface and the second surface energy results in a hydrophobic surface. A diameter of the elements is at least 1 mm. A height of the overlay having the second surface energy, which results in a hydrophobic surface, is between 5% and 100% of the diameter of the elements. The apparatus also includes a wall circumferential to the plate. A method for performing multiple reactions with the apparatus is also disclosed.Type: ApplicationFiled: January 30, 2018Publication date: August 9, 2018Inventors: Namyong KIM, Siah Chong Cheong, Melvin Han Wen Lye, Mark Siew Peng Phong, Li Li, Teow Soon Seah
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Patent number: 9950323Abstract: A device includes a first structure with a sheet layer with a plurality of discrete through-holes and a second structure coupled to the first structure. At least a portion of a first surface of the sheet layer of the first structure is exposed from the second structure. A top portion of the sheet layer, including the exposed portion of the first surface of the sheet layer, includes fluorocarbon. The second structure includes a material of a higher surface tension than the top of the sheet layer. A second surface of the sheet layer, opposite to the first surface of the sheet layer, is embedded in the second structure. The second structure extends at least partially into the plurality of discrete through-holes of the first structure.Type: GrantFiled: August 5, 2014Date of Patent: April 24, 2018Assignee: CURIOX BIOSYSTEMS PTE LTD.Inventors: Namyong Kim, Eng Seng Lim, Siah Chong Cheong
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Patent number: 9878328Abstract: This describes an apparatus comprising a plate with a number of elements having a hydrophilic surface arranged in an array with an overlay having a hydrophobic surface. A height of the overlay is between about 5% and 100% of the diameter of the elements. The application also discloses a wall circumferential to the plate; and a removable grid insertable into the apparatus, said grid comprising dividers enclosing a number of through-holes, said through-holes spaced in the grid to allow alignment of the through-holes of the grid over the elements in the plate when said grid is inserted into the apparatus, said dividers of the grid inserted into the apparatus form sides of wells bottomed by the plate and at least one element on said plate.Type: GrantFiled: July 25, 2011Date of Patent: January 30, 2018Assignee: Curiox Biosystems Pte Ltd.Inventors: Namyong Kim, Siah Chong Cheong, Melvin Han Wen Lye, Mark Siew Peng Phong, Li Li, Teow Soon Seah
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Publication number: 20150017079Abstract: A device includes a first structure with a sheet layer with a plurality of discrete through-holes and a second structure coupled to the first structure. At least a portion of a first surface of the sheet layer of the first structure is exposed from the second structure. A top portion of the sheet layer, including the exposed portion of the first surface of the sheet layer, includes fluorocarbon. The second structure includes a material of a higher surface tension than the top of the sheet layer. A second surface of the sheet layer, opposite to the first surface of the sheet layer, is embedded in the second structure. The second structure extends at least partially into the plurality of discrete through-holes of the first structure.Type: ApplicationFiled: August 5, 2014Publication date: January 15, 2015Inventors: Namyong KIM, Eng Seng LIM, Siah Chong CHEONG
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Publication number: 20140235468Abstract: The present invention provides an apparatus for conducting biological assays which employs “virtual wells” in lieu of the physical wells of conventional array plates. Also provided are methods of processing a sample and/or culturing cells using the apparatus and systems described herein. In some embodiments, the apparatus includes a first structure having a sheet layer with a plurality of discrete through holes; and a second structure coupled to the first structure, the second structure including a base layer. At least a portion of a first surface of the sheet layer of the first structure is exposed from the second structure, and a second surface of the sheet layer, opposite to the first surface of the sheet layer, is embedded in the base layer of the second structure adjacent the first surface of the base layer.Type: ApplicationFiled: October 9, 2013Publication date: August 21, 2014Applicant: Curiox Biosystems Pte Ltd.Inventors: Kong L. Cheng, Siah Chong Cheong, Namyong Kim, Eng Seng Kim, Melvin H.W. Lye, Zhong Wang, Wan Yee Leong, Mark S. Phong
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Publication number: 20130123139Abstract: In some embodiments, the invention relates to a removable grid insertable into an apparatus comprising a plate comprising a number of elements having a first surface energy arranged in an array with an overlay having a second surface energy and a wall circumferential to the plate, said grid comprising dividers enclosing a number of through-holes, said through-holes spaced in the grid to allow alignment of the through- holes of the grid over the elements in the plate when said grid is inserted into the apparatus, wherein said dividers of the grid inserted into the apparatus form sides of wells bottomed by the plate and at least one element on said plate.Type: ApplicationFiled: July 25, 2011Publication date: May 16, 2013Inventors: Namyong Kim, Siah Chong Cheong, Melvin Han Wen Lye, Mark Siew Peng Phong, Li Li, Teow Soon Seah