Abstract: The invention relates to the discovery of a previously unknown population of adipocytes marked by active intracellular Wnt/?-catenin signaling. The present invention provides methods of making populations of adipocytes in which the proportion of these “Wnt+ adipocytes” is much higher than those in naturally occurring populations. Wnt+ adipocytes can be used to improve blood glucose control and exosomes secreted by Wnt+ adipocytes can be administered to reduce blood glucose levels in subjects in need thereof.

Abstract: The present disclosure provides a bike sharing rebalancing optimization method based on an adaptive neighborhood search algorithm. First, based on a difference between locations of shared bikes and users' travel demands in temporal and spatial distribution, a bike sharing rebalancing model is constructed. Next, an adaptive neighborhood search algorithm is constructed by using an adaptive operator selection mechanism and based on the fusion of a large neighborhood search algorithm and a neighborhood search algorithm. Then, seven types of perturbation operators, six types of repair operators, and eight types of neighborhood search operators are designed based on features of rebalancing time, pickup-and-delivery actions, and a capacity limit of a vehicle. Finally, a termination condition is constructed such that the algorithm terminates at an appropriate time and an optimization solution for a rebalancing route is provided.

Abstract: A method for creating a response to a hypertext transfer protocol (HTTP) request from a mobile device. The HTTP request is received from the mobile device. A determination may be made as to whether to optimize the response based on the HTTP request. If it is determined that the response is to be optimized, then an action to be performed on an object in connection with optimizing the response is determined. The object may be part of a document specified in the HTTP request. An optimized response may then be generated based on the action.