Abstract: The present disclosure discloses a flammable and explosive liquid transportation system and a method and an application thereof. The system includes a gas inlet pipe and a liquid transportation pipeline; a first valve and a second valve are sequentially disposed on the gas inlet pipe; two ends of the liquid transportation pipeline respectively communicate with the raw material barrel and a reaction vessel, a third valve, a fifth valve, and a seventh valve are sequentially disposed on the liquid transportation pipeline; the gas inlet pipe and the liquid transportation pipeline communicate with each other, and a fourth valve is disposed on the connecting pipe; a bypass pipe is disposed on the liquid transportation pipeline, and a sixth valve is disposed on the bypass pipe. The present disclosure resolves problems of a high risk and poor environmental protection caused by an existing flammable and explosive liquid transfer manner.

Abstract: A continuous delivery preparation capable of being stably released and a preparation method therefor, wherein the preparation includes an active pharmaceutical ingredient and a gel carrier, and the gel carrier includes a biodegradable polymer, an organic solvent, a hydrophobic additive, and an optional hydrophilic gel matrix material. Compared with an in-situ gel prepared using a conventional Atrigel technology, the delivery preparation has the effect of slowing down in vitro and vivo burst release of the drug after a small amount of the hydrophobic additive and the optional hydrophilic gel matrix material are added, and the in-vivo blood drug concentration can be maintained for more than one week in a safe and effective range. The preparation method of the preparation is simple.

Abstract: A long-acting brexpiprazole preparation for injection and a preparation method therefor. The preparation method therefor comprises: (a) dissolving brexpiprazole in an organic solvent to form a brexpiprazole solution; (b1) pumping the brexpiprazole solution into a sheared or violently stirred precipitation solvent, so as to precipitate brexpiprazole, or (b2) pumping the precipitation solvent into the sheared or violently stirred brexpiprazole solution, so as to precipitate brexpiprazole; (c) filtering and optionally using water to wash an obtained solid; and (d1) drying the obtained solid, and respectively packaging the dried solid and an auxiliary material solution to obtain the long-acting brexpiprazole preparation for injection, or (d2) dispersing the obtained solid into the auxiliary material solution to obtain the long-acting brexpiprazole preparation for injection.

Abstract: The present disclosure discloses a flammable and explosive liquid transportation system and a method and an application thereof. The system includes a gas inlet pipe and a liquid transportation pipeline; a first valve and a second valve are sequentially disposed on the gas inlet pipe; two ends of the liquid transportation pipeline respectively communicate with the raw material barrel and a reaction vessel, a third valve, a fifth valve, and a seventh valve are sequentially disposed on the liquid transportation pipeline; the gas inlet pipe and the liquid transportation pipeline communicate with each other, and a fourth valve is disposed on the connecting pipe; a bypass pipe is disposed on the liquid transportation pipeline, and a sixth valve is disposed on the bypass pipe. The present disclosure resolves problems of a high risk and poor environmental protection caused by an existing flammable and explosive liquid transfer manner.