Abstract: This disclosure relates to methods and systems for a curated genetic variant database and systems and methods for submitting new genetic tests based on the information in the curated database. The methods and systems of the invention further provide for a single curated variant database that allows curation of genetic variants while protecting the proprietary nature of the information submitted to the database. The system and methods also provide for submission of new genetic tests based on genetic variants, conducting genetic tests, and for determining payments to submitters and test developers based on the genetic tests.

Abstract: Disclosed are systems and methods for managing and using a curated genetic biomarker database. The systems and methods allow for submission and curation of genetic biomarkers, the development of new genetic tests based on the submitted biomarkers, conducting the genetic tests, and accounting for payments due to biomarker submitters and test developers for use of the genetic tests.