Patents by Inventor Siden Top

Siden Top has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metallocene derivatives with anticancer activity
    Patent number: 9758541
    Abstract: The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt or solvate thereof, a stereoisomer or a mixture of stereoisomers in any ratio, or a water-soluble derivative, as well as to methods for preparing same and to the use thereof, in particular in the treatment of cancer.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: September 12, 2017
    Assignee: PARIS SCIENCES ET LETTRES—QUARTIER LATIN
    Inventors: Gerard Jaouen, Pascal Pigeon, Siden Top
  • Metallocene Derivatives with Anticancer Activity
    Publication number: 20170166600
    Abstract: The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt or solvate thereof, a stereoisomer or a mixture of stereoisomers in any ratio, or a water-soluble derivative, as well as to methods for preparing same and to the use thereof, in particular in the treatment of cancer.
    Type: Application
    Filed: October 30, 2014
    Publication date: June 15, 2017
    Inventors: Gerard Jaouen, Pascal Pigeon, Siden Top
  • Diarylethylene metallocene derivatives, their processes of preparation and pharmaceutical compositions containing said derivatives
    Patent number: 5863911
    Abstract: Diarylethylene metallocene derivatives, processes for preparing the same and pharmaceutical compositions which contain the derivatives are disclosed. The compounds of the invention can exhibit anti-tumor activity, and can be particularly useful in the treatment of estrogen-dependent cancers.
    Type: Grant
    Filed: August 11, 1997
    Date of Patent: January 26, 1999
    Assignee: Modelisation et Mise au Point de Molecules Medicinales
    Inventors: Gerard Jaouen, Siden Top
  • Labelling of hormones with rhenium and tecnetium
    Patent number: 5554602
    Abstract: The disclosed invention is drawn to the organometallic oestrogen complex of formula (I): ##STR1## in which A is a C.sub.1-7 alkylene radical or C.sub.2-7 alkenylene or alkynylene radical; M.sub.x is one or more identical or different transition metals; L'.sub.y is one or more identical or different ligands complexing the metal(s) of M.sub.x ; and L is a ligand for covalently coupling M.sub.x to A; and R is H or a C.sub.1-7 alkyl or alkoxy group which may be optionally substituted, particularly with one or more halogens. These complexes are useful for the treatment of hormone-dependent cancers. Also, when the metals of the complex M.sub.x are radioactive isotopes suitable for imaging, the complexes are useful as imaging agents.
    Type: Grant
    Filed: April 12, 1993
    Date of Patent: September 10, 1996
    Assignee: LaRegion Wallone
    Inventors: Siden Top, Anne Vessieres, G'erard Jaquen, Jacques Quivy
  • Organometallic complexes of estrogens and their application to the determination of hormone receptors
    Patent number: 4983646
    Abstract: The present invention relates to an estrogen complex which consists of an estrogen or an estrogen derivative complexed with an organometallic compound containing at least one free carbonyl ligand, the said estrogen complex containing at least one free hydroxyl radical and no free phenolic hydroxyl radical in the .alpha.-position to the site where the organometallic compound is attached.The complexes according to the invention are useful for the determination of hormone receptors.
    Type: Grant
    Filed: July 24, 1988
    Date of Patent: January 8, 1991
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Gerard Jaouen, Anne Vessieres, Siden Top
  • Organometallic complexes of estrogens and their application to the determination of hormone receptors
    Patent number: 4656142
    Abstract: The present invention relates to an estrogen complex which consists of an estrogen or an estrogen derivative complexed with an organometallic compound containing at least one free carbonyl ligand, the said estrogen complex containing at least one free hydroxyl radical and no free phenolic hydroxyl radical in the .alpha.-position to the site where the organometallic compound is attached.The complexes according to the invention are useful for the determination of hormone receptors.
    Type: Grant
    Filed: September 20, 1983
    Date of Patent: April 7, 1987
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Gerard Jaouen, Anne Vessieres, Siden Top